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Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019


Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients

Disease Markers, Volume 2019, 10 pages, https://doi.org/10.1155/2019/3652894
Jarosław Wajda,1 Maciej Świat,2,3 Aleksander J. Owczarek,4 Aniceta Brzozowska,5 Magdalena Olszanecka-Glinianowicz,5 and Jerzy Chudek6,7

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Background. Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS.

Methods. Serum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS. Mortality data was obtained from the local registry office.

Results.

  • Only three subjects (1.3%) had an optimal 25-OH-D level (30-80 ng/mL),
  • 25 (10.4%) had a mildly reduced (insufficient) level,
  • 61 (25.4%) had moderate deficiency, and
  • 151 (62.9%) had a severe VD deficiency.

20% subjects had secondary hyperparathyroidism. The serum 25-OH-D level was significantly lower than that in 480 matched subjects ( vs.  ng/mL).
Of all the patients, 79 (32.9%) died during follow-up observation (44.9 months).
The mortality rates (per year) were 4.81 and 1.89 in a group with and without severe VD deficiency, respectively (incidence rate ratio: 2.52; 95% CI: 1.44–4.68). There was no effect of secondary hyperparathyroidism and iFGF23 levels on mortality rates. Age,  ng/mL, and functional status (modified Rankin scale) were significant factors increasing the risk of death in multivariable Cox proportional hazard regression test.

Conclusions. Severe VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status. VD supplementation in IS survivals may be considered due to high prevalence of its deficiency. However, it is uncertain whether it will improve their survival.


VitaminDWiki – Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke


Stroke Meta-analysis

Stroke Mortality


Stroke and Intervention:


23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated

Items found: 23
Title Modified
Ischemic Stroke is 18% more likely if poor Vitamin D genes (unless take more Vitamin D) – Feb 2024 21 Mar, 2024
High Omega-3 reduced risk of Ischemic stroke by 18% - Dec 2023 05 Jan, 2024
Elderly vaccinated for COVID were 2X more likely to die of ischemic stroke (2930 vs 1180 deaths)– Nov 2021 22 Nov, 2021
Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016 05 Mar, 2021
Poor Ischemic stroke outcome (END) 2.6 X worse if low vitamin D – March 2019 26 Nov, 2019
Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019 02 May, 2019
Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018 29 Jun, 2018
Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018 28 Feb, 2018
Ischaemic Stroke has less impact in animals supplemented with Omega-3 – Jan 2018 13 Feb, 2018
Vitamin D levels drop after ischemic stroke – Dec 2017 20 Jan, 2018
Ischemic stroke 17 X more likely if low vitamin D – April 2017 13 Jan, 2018
Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017 04 Jan, 2018
Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017 27 Oct, 2017
Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017 04 Oct, 2017
Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017 01 Aug, 2017
Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017 01 Aug, 2017
Risk of Ischemic Stroke doubles if take more than 1 gram of Calcium daily for years – May 2017 20 May, 2017
Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017 02 Mar, 2017
Ischemic Stroke with low vitamin D resulted in larger lesions – May 2015 11 Mar, 2016
Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012 12 Jul, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Acute ischemic stroke 19 percent more likely if even lower vitamin D – Sept 2013 14 Sep, 2013


Created by admin. Last Modification: Thursday March 21, 2024 11:59:53 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
11890 Stroke caption.jpg admin 02 May, 2019 12.57 Kb 449
11889 Stroke survival.jpg admin 02 May, 2019 38.88 Kb 591
11888 Ischemic Stroke.pdf admin 02 May, 2019 1.61 Mb 580