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DHCR7 enzyme (gene) synthesizes cholesterol or vitamin D (when UVB is available) – paywall Sept 2016

DHCR7: A vital enzyme switch between cholesterol and vitamin d production

Progress in Lipid Research, online 30 Sept 2016, http://dx.doi.org/10.1016/j.plipres.2016.09.003
Anika V. Prabhua, Winnie Luua, Dianfan Lib, Laura J. Sharpea, Andrew J. Browna, ,

See also VitaminDWiki

Genetics category listing contains the following

229 articles in the Genetics category

see also 246 articles in Vitamin D Receptor, 92 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 47+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4


The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol reductase (DHCR7). Homozygous or compound heterozygous mutations in DHCR7 lead to the developmental disease Smith-Lemli-Opitz syndrome, which can also result in fetal mortality, highlighting the importance of this enzyme in human development and survival. Besides serving as a substrate for DHCR7, 7-dehydrocholesterol is also a precursor of vitamin D via the action of ultraviolet light on the skin.
Thus, DHCR7 exerts complex biological effects, involved in both cholesterol and vitamin D production. Indeed, we argue that DHCR7 can act as a switch between cholesterol and vitamin D synthesis. This review summarizes current knowledge about the critical enzyme DHCR7, highlighting recent findings regarding its structure, transcriptional and post-transcriptional regulation, and its links to vitamin D synthesis. Greater understanding about DHCR7 function, regulation and its place within cellular metabolism will provide important insights into its biological roles.

Publisher wants $40 for the PDF
Outline
1. Introduction
1.1. The history of DHCR7
2. Implications in Human Health And Disease
2.1. Smith-Lemli-Opitz syndrome
2.2. Health effects of 7-dehydrocholesterol and its derivatives
2.3. Role of sterols in embryogenesis
2.4. Vitamin D3 status
3. Characterization of The DHCR7 protein
3.1. DHCR7 topology and structure
3.2. Important domains of DHCR7
3.3. Evolution of DHCR7
4. Regulation of DHCR7
4.1. Transcriptional regulation of DHCR7
4.2. Post-transcriptional regulation of DHCR7
5. Concluding Remarks

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