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Cystic fibrosis treatment by vitamin D improved quality of life and breathing (8200 IU daily)– RCT Dec 2016

Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial.

Eur J Clin Nutr. 2016 Dec 14. doi: 10.103\8/ejcn.2016.259. [Epub ahead of print]
Pincikova T1,2,3, Paquin-Proulx D3, Sandberg JK3, Flodström-Tullberg M3, Hjelte L1,2.
1Stockholm CF Center, Karolinska University Hospital Huddinge, Stockholm, Sweden.
2Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
3Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

See also VitaminDWiki

This study did not start with a loading dose,
   so it took probably 2+ months to raise vitamin D levels to where there can be a benefit

Might have been much better results with
1) Loading dose and/or
2) Inhaled Vitamin D

See also VitaminDWiki

See also VitamiDWiki - more than Vitamin D treats CF

What would be the benefit to CF if all three were used concurrently?
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 Download the PDF from VitaminDWiki

Vitamin D levels suring suplementation and after

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Change in Quality of Life vs active level of vitamin D

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BACKGROUND/OBJECTIVES:
Vitamin D insufficiency in cystic fibrosis is common. Vitamin D3 is currently preferred over D2.
We aimed to study the efficacy of vitamin D2 and D3 at increasing serum 25-hydroxyvitamin D (s25OHD) concentrations and their effect on respiratory health in cystic fibrosis.

SUBJECTS/METHODS:
Sixteen CF patients were randomized to receive vitamin D2 or D3 or to serve as controls. The starting dose of

  • 5000 IU (<16 years old) or
  • 7143 IU/day ( 16 years old)

was further individually adjusted. Three months of intervention were followed by two of washout (ClinicalTrials.gov NCT01321905).

RESULTS:
To increase s25OHD, the mean daily dose of vitamin D2 and D3 had to be increased up to 15650 and 8184 IU, respectively.
The combined group of vitamin D2 and D3 treated patients decreased plasma IL-8 (P<0.05). Patients provided vitamin D3 improved FVC at the end of the trial (P<0.05).
Change in s25OHD was positively correlated with changes in the

  • adult Quality-of-Life respiratory score at the end of supplementation (P=0.006, r=0.90), and with changes in
  • FEV1 (P=0.042, r=0.62) and FVC (P=0.036, r=0.63) at one month of washout.


CONCLUSIONS:
Vitamin D supplementation may contribute to reduced inflammation and improved lung function in CF.

PMID: 27966575 DOI: 10.1038/ejcn.2016.259


See also Web

Attached files

ID Name Comment Uploaded Size Downloads
7535 Change in QoL for CF.jpg admin 20 Dec, 2016 02:51 13.52 Kb 244
7534 CF RCT.jpg admin 20 Dec, 2016 02:24 22.31 Kb 259
7533 CF RCT Dec 2016.pdf PDF 2016 admin 20 Dec, 2016 02:23 492.85 Kb 145
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