Effect of 25-hydroxyvitamin D3 during prepartum transition and lactation on production, reproduction, and health of lactating dairy cows
Journal of Dairy Science. online 2 March 2021, https://doi.org/10.3168/jds.2020-18901
H.M.Golder1J.McGrath2I.J.Lean1
4 sample herds CON = no vitamin D TRT = 2 mg of calcdiol daily
- Overview Veterinary and vitamin D
- Calcifediol (Calcidiol) might be a better form of Vitamin D for some people – May 2019
- Oral calcidiol is a good form of vitamin D supplementation – Aug 2017
- Getting Vitamin D into your body has the following chart
Calcidiol category starts with
Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also
- Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
- Tests for Vitamin D
156 items - Calcitriol
56 items - Injection
62 items - Forms of Vitamin D
104 items - Response to Vitamin D - many studies 166 as of April 2023
- Nanoemulsion Vitamin D is faster and better - many studies
- Response to Nanoemulstion Vitamin D swished in the mouth appears to start in 2 hours
- Calcidiol is available only by prescription and is expensive
- Calcidiol - daily dose has fast response, but weekly might be better - March 2018
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Highest milk yield for CON-TRT in all 4 daries (samples)
Mistakes were made at some daries - failed to give the vitamin D
We hypothesized that feeding 25-hydroxyvitamin D3 [25-(OH)D3] during lactation and prepartum in conjunction with negative dietary cation-anion difference diets would improve milk production, increase the probability of pregnancy, and reduce the incidence of postcalving diseases. Cows from 4 dairies with prepartum transition diets negative in dietary cation-anion difference were used in 2 randomized cohort experiments.
In Experiment 1 (Exp. 1), cows were assigned to control [CON; n = 645; no 25-(OH)D3] or treatment [RT; n = 537; 2 mg/d of 25-(OH)D3 from ∼21 d prepartum to parturition and 1 mg/d in lactation] groups at ∼21 d prepartum. Cows were monitored for weekly milk yield, milk composition every 60 d, and health and reproductive measures.
In Experiment 2 (Exp. 2), cows (n = 2,064; median 147 d in milk) were assigned to 4 groups and monitored for the same measures as in Exp. 1 to the end of that lactation (L1), the subsequent transition (∼21 d prepartum to parturition), and the next lactation (L2). Groups were as follows, with the amount of 25-(OH)D3 fed (mg/d) indicated in parentheses for L1, transition, and L2, respectively:
- (A) control-control (CON-CON; 0–0–0),
- (B) treatment-treatment (TRT-TRT; 1–2–1),
- (C) control-treatment (CON-TRT; 0–2–1), and
- (D) treatment-control (TRT-CON; 1–0–0).
For L1, a total of 1,032 cows entered the control groups A or C and a total of 1,032 cows in groups B or D. The number of cows in groups A to D that entered L2 was 521, 523, 273, and 248, respectively. Blood calcium, phosphorus, and 25-(OH)D3 concentrations were measured from 17 cows/group at 5 times.
In Exp. 1, TRT cows had 0.2 lower log somatic cell count than (LnScc) CON cows (4.21 ± 0.045 vs. 4.01 ± 0.050, respectively) and multiparous TRT cows had 41 ± 23% higher probability of pregnancy/day than multiparous CON cows, resulting in a 22-d median decrease in time to pregnancy.
Primiparous TRT cows had 1.67 ± 0.40 times greater odds of mastitis/day than primiparous CON cows.In Exp. 2 TRT-TRT cows had between 16 and 29% lower probability to be bred/day than other groups. Multiparous CON-CON and TRT-CON cows had 20 ± 8% and 30 ± 17% greater probability of pregnancy, respectively, than multiparous TRT-TRT cows. Serum calcium concentrations were not affected by group, but phosphorus and 25-(OH)D3 concentrations were highest in the TRT-TRT cows. The study provides further insights into the use of 25(OH)D3 in transition and lactation.
Treatment plan (I could not figure it out)
Cows gave more milk after pregancy if given Calcidiol (semi-activated Vitamin D) – RCT March 20213725 visitors, last modified 07 Mar, 2021, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 15185 Cows treatment plan.jpg admin 06 Mar, 2021 179.62 Kb 279 15184 CON-TRT caption.jpg admin 06 Mar, 2021 11.27 Kb 265 15183 Milk yield vs TRT and CON.jpg admin 06 Mar, 2021 65.75 Kb 267 15182 Cows 4 cases.jpg admin 06 Mar, 2021 32.43 Kb 265 15180 Cows vitsamin D sample time.jpg admin 06 Mar, 2021 93.68 Kb 268 15179 Cows Vitamin D after pregnancy RCT_compressed.pdf admin 06 Mar, 2021 1.16 Mb 319 - Calcitriol