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Coronary Artery Disease 2.9 X more likely in postmenopausal women if Vitamin D deficient – March 2020

Association of Vitamin D Status With Coronary Artery Disease in Postmenopausal Women

Medicine (Baltimore) , 99 (11), e19544 Mar 2020, DOI: 10.1097/MD.0000000000019544
Rui Xu 1, Yan-Yan Li 2, Ling-Ling Ma 1, Hong-Ni Yang 1

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The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged. Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency. To investigate the relationship between CAD and VitD levels in PM women.This case-control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL).
Major cardiovascular risk factors were also explored.CAD occurred in

  • 67/127 (52.8%) patients with VitD deficiency;
  • 21/66 (31.8%) patients that were VitD insufficient; and in
  • 5/19 (26.3%) patients with adequate VitD levels.

Multivariate regression analysis suggested that a deficiency of VitD increased CAD (odds ratio = 2.891; 95% confidence interval = 1.459-7.139, P < .001).
VitD deficiency should be evaluated in PM women as a possible cause of CAD.


GrassrootsHealth description of the study

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Created by admin. Last Modification: Thursday April 8, 2021 01:31:45 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
13684 Xu GRH.jpg admin 25 Mar, 2020 90.71 Kb 285
13651 Association_of_vitamin_D_status_with_coronary.85.pdf admin 19 Mar, 2020 207.62 Kb 394