Association between vitamin D status and cognitive impairment in acute ischemic stroke patients: a prospective cohort study.
Clin Interv Aging. 2018 Dec 10;13:2503-2509. doi: 10.2147/CIA.S187142. eCollection 2018.
Chen H1, Liu Y1, Huang G1, Zhu J2, Feng W2, He J1.
- Following strokes, brain scans (MRI) 3X worse in those having low vitamin D – July 2018
- Strokes 3 X worse if low vitamin D – Jan 2018
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Can reduce the problem if immediately take vitamin D after a stroke
- Low vitamin D at time of stroke predicts 3 X more likely to die in a month (unless add Vit D) – Dec 2017
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
Can greatly reduce the risk of the stroke if vitamin D levels have been restored
- Cognitive impairment after stroke increased if Vitamin D deficient - Dec 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- Blacks with strokes having low Vitamin D were 3 times more likely to have cognitive impairment – Nov 2016
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Stroke results in 8 years of cognitive decline (vitamin D not mentioned) May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Fewer white spots in MRI brain scans if had more vitamin D – Jan 2014
- 5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011
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VDD is < 10 ng
Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, vitamin D deficiency has been linked with cognitive decline. Our study aimed to explore the potential relationship between vitamin D levels in the short-term acute phase of ischemic stroke and cognitive impairment at 1 month.
In total, 354 ischemic stroke patients were consecutively enrolled in the study and received 1-month follow-up. The serum levels of vitamin D were measured within 24 hours after admission. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after acute ischemic stroke. Cognitive impairment was defined according to different education levels.
According to MMSE scores, 114 participants (32.2%) had cognitive impairment at 1 month. Patients with vitamin D deficiency were more likely to have cognitive impairment than those with vitamin D insufficiency and vitamin D sufficiency (P<0.001). After adjusting for potential confounders in our Cox proportional hazards model, vitamin D deficiency was independently associated with the development of cognitive impairment in acute ischemic stroke patients.
Independent of established risk factors, vitamin D deficiency in the short-term phase of ischemic stroke was associated with a higher incidence of 1-month cognitive impairment.