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Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018

Vitamin D receptor (VDR) gene polymorphism and vascular dementia due to cerebral small vessel disease in an Asian Indian cohort

Journal of the Neurological Sciences https://doi.org/10.1016/j.jns.2018.05.025
Manjunath Supriyaa Sadanandavalli Retnaswami Chandrab Puttachandra Prabhakara Chandrajit Prasadc Rita Christophera


From Cerebral Small Vessel Disease: What to Know & What to Do 2018?
It appears that cerebral small vessel disease can increase

  • White portions of MRI (poor blood flow) aka White matter hyperintensities
    • Note: Multiple Sclerosis shows up as increased white matter on MRIs
  • Cognitive decline
  • Problems with walking or balance
  • Strokes
  • Vascular dementia.

Note: Poor Vitamin D Receptors result in less Vitamin D getting to cells,
   but DOES NOT reduce the Vitamin D levels in the blood

Items in both categories Cognition and Vitamin D Receptor are listed here:

Items in both categories Stroke and Vitamin D Receptor are listed here:

Items in both categories Parkinson's and Vitamin D Receptor are listed here:

Vitamin D Receptor category has the following

494 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (18 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (23 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (33 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


  • Vitamin D acting through VDR plays a crucial role in vascular health.
  • VDR FokI “f” allele increases risk of cerebral SVD by 1.5-fold in men.
  • Serum vitamin D is significantly lower in subjects with FokI “ff” genotype.
  • FokI “ff” increases risk of SVD by 2.5-fold in subjects with low serum vitamin D
  • ApaI polymorphism confers protection against SVD in women.

Vitamin D receptor (VDR) and its ligand Vitamin D, play a crucial role in regulating multiple pathways for maintaining vascular health. The present study aimed at evaluating whether single nucleotide polymorphisms in VDR gene were associated with susceptibility to vascular dementia (VaD) due to cerebral small vessel disease (SVD). A total of 644 subjects (302 patients diagnosed with cerebral SVD-associated VaD and 342, age- and gender-matched healthy controls) were genotyped for VDR gene variants, FokI, ApaI, TaqI and BsmI, by PCR-RFLP method. Among the 4 examined VDR variants, the presence of the minor allele (Ff+ff vs FF) of FokI variant increased the risk for cerebral SVD by 1.5-fold in men (p = 0.047). Serum 25-hydroxyvitamin D [25(OH)D] was lower in subjects having the FokI “ff” genotype compared to those with the “FF” genotype (p = 0.044). Moreover, in subjects with low serum 25(OH)D the presence of “ff” genotype increased the odds of SVD by 2.5 folds (p = 0.041). ApaI polymorphism decreased the risk of cerebral SVD in women. The distribution of TaqI and BsmI variants were not significantly different between patients and controls. Further studies in large cohorts are necessary to validate the role of FokI polymorphism in cerebral SVD and VaD etiopathogenesis.

Created by admin. Last Modification: Saturday June 23, 2018 18:05:56 GMT-0000 by admin. (Version 4)