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Cardiovascular risk factors not reduced by small amount of vitamin D for only 4 months – RCT May 2018

Vitamin D supplementation does not improve CVD risk factors in vitamin D insufficient subjects.

Endocr Connect. 2018 May 15. pii: EC-18-0144. doi: 10.1530/EC-18-0144. [Epub ahead of print]
Kubiak JM1, Thorsby PM2, Kamycheva E3, Jorde R4.

VitaminDWiki

Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months
   20,000 IU weekly = 2,900 IU daily
Many studies are recommending that everyone needs at least 4,000 IU daily for health


See also VitaminDWiki


Cardiovascular category starts with the following

371 items In Cardiovascular category

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 366 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Diabetes category starts with the following

366 items In Diabetes category

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 106 items along with related searches

T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018


Hypertension category listing contains the following

115 items in the category HYPERTENSION

see also
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 30 health problems related to vitamin D has doubled in a decade
160% increase per decade (women, age adjusted)
Image

 Download the PDF from VitaminDWiki

OBJECTIVE:
Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects.

DESIGN: Double-blinded randomized controlled trial.

METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of:

  • blood pressure,
  • lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B ), and
  • glucose metabolism parameters
    (blood glucose,HbA1c, sRAGE (minor improvement), insulin, C-peptide, and HOMA-IR).

RESULTS:
422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group.
Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.

CONCLUSION: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factors profile.

PMID: 29764903 DOI: 10.1530/EC-18-0144

Created by admin. Last Modification: Thursday May 17, 2018 13:31:07 UTC by admin. (Version 5)

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