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Cardiovascular death 40 percent more likely in a decade if chest pain and low Vitamin D - March 2018

Plasma 25-Hydroxyvitamin D and Mortality in Patients With Suspected Stable Angina Pectoris

The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 3, 1 March 2018, Pages 1161–1170, https://doi.org/10.1210/jc.2017-02328
Eirik Degerud Ottar Nygård Stefan de Vogel Rune Hoff Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Dennis Winston Trygve Nilsen Jan Erik Nordrehaug Øivind Midttun Per Magne Ueland

  • Note: 70-80% were taking statins, which is known to decrease vitamin D from the sun
  • Speculation: Those patients who had a good level of vitamin D (> 40ng) at the start had gotten it from the sun.
    Statins will have greatly reduced their vitamin which they would get from the sun.
    There were no vitamin D measurements near the time of death to confirm or refute this hypothesis
  • Wonder if long-term use of baby aspirin by half ot adults > age 65 reduces vitamin D
  • Wonder if long-term use of blood thinners reduces Vitamin D levels

Cardiovascular category starts with the following

511 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

Cholesterol, Statins

PDF was available free at Sci-Hub.tv as of March 2018

Context and Objective
Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and all-cause and cardiovascular mortality risk.

Design, Setting, Participants, and Main Outcome Measures
25OHD, the sum of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2, was analyzed in plasma samples from 4114 white patients suspected of having stable angina pectoris and was adjusted for seasonal variation. Hazard ratios (HRs) for all-cause and cardiovascular mortality were estimated by using multivariable Cox models with 25OHD as the main exposure variable, with adjustment for study site, age, sex, smoking, body mass index, estimated glomerular filtration rate, and systolic blood pressure.

A total of 895 (21.8%) deaths, including 407 (9.9%) from CVD causes, occurred during a mean ± standard deviation follow-up of 11.9 ± 3.0 years. Compared with the first 25OHD quartile, HRs in the second, third, and fourth quartiles were

  • 0.64 (95% confidence interval (CI), 0.54 to 0.77),
  • 0.56 (95% CI, 0.46 to 0.67), and 0.56 (95% CI)
  • 0.46 to 0.67) for all-cause mortality


  • 0.70 (95% CI, 0.53 to 0.91),
  • 0.60 (95% CI, 0.45 to 0.79), and
  • 0.57 (95% CI, 0.43 to 0.75)

for cardiovascular mortality, respectively.
Threshold analysis demonstrated increased all-cause and CVD mortality in patients with 25OHD concentrations below ∼42.5 nmol/L. Moreover, analysis suggested increased all-cause mortality at concentrations >100 nmol/L.

Plasma 25OHD concentrations were inversely associated with cardiovascular mortality and nonlinearly (U-shaped) associated with all-cause mortality.

Created by admin. Last Modification: Monday December 31, 2018 17:15:23 GMT-0000 by admin. (Version 9)

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