Loading...
 
Toggle Health Problems and D

Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018

Vitamin D supplementation does not improve CVD risk factors in vitamin D insufficient subjects.

Endocr Connect. 2018 May 15. pii: EC-18-0144. doi: 10.1530/EC-18-0144. [Epub ahead of print]
Kubiak JM1, Thorsby PM2, Kamycheva E3, Jorde R4.

VitaminDWiki

Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months
   20,000 IU weekly = 2,900 IU daily
Many studies are recommending that everyone needs at least 4,000 IU daily for health


See also VitaminDWiki


Cardiovascular category starts with the following

464 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022


Cholesterol, Statins


Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 511 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 24;   Intervention 55;   Meta-analysis 36;   Obesity 32;  Pregnancy 42;   T1 (child) 38;  Omega-3 11;  Vitamin D Receptor 22;  Genetics 12;  Magnesium 25    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes

Pre-Diabetes

Magnesium


Diabetes category starts with the following

511 items In Diabetes category

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 186 items along with related searches

Hypertension category listing contains the following

155 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

 Download the PDF from VitaminDWiki

OBJECTIVE:
Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects.

DESIGN: Double-blinded randomized controlled trial.

METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of:

  • blood pressure,
  • lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B ), and
  • glucose metabolism parameters
    (blood glucose,HbA1c, sRAGE (minor improvement), insulin, C-peptide, and HOMA-IR).

RESULTS:
422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group.
Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.

CONCLUSION: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factors profile.

PMID: 29764903 DOI: 10.1530/EC-18-0144


Created by admin. Last Modification: Monday September 10, 2018 14:03:15 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
9874 not improve CVD risk factors.pdf PDF 2018 admin 17 May, 2018 12:57 549.88 Kb 495
See any problem with this page? Report it (WORKS NOV 2021)