Can Vitamin D Supplementation Improve Physical Function and Quality of Life in Older Patients With Heart Failure?
Circulation: Heart Failure. 2010;3:183-184
Emily B. Levitan, ScD and Suzanne E. Judd, PhD
From the Departments of Epidemiology (E.B.L.) and Biostatistics (S.E.J.), University of Alabama at Birmingham School of Public Health, Birmingham, Ala.
Correspondence to Emily B. Levitan, ScD, Department of Epidemiology, University of Alabama at Birmingham, RPHB 230K, 1530 3rd Avenue S, Birmingham, AL 35294-0022. E-mail elevitan at uab.edu
An extract of the first 250 words of the full text is provided, because this article has no abstract.
Although early research on vitamin D focused on the effects of vitamin D deficiency on bone metabolism, more recent work has found a vast variety of roles for vitamin D throughout the body.1 Studies suggest that too little vitamin D might increase the risk for conditions as diverse as cardiovascular disease, cancer, autoimmune disease, and depression.1 The optimal level of vitamin D is not known, but there is general agreement that serum 25-hydroxyvitamin D <50 nmol/L (20 ng/mL) represents deficiency.1 However, some researchers have suggested that levels >80 nmol/L may be required for optimal health.2
Article see p 195
Vitamin D deficiency is common in patients with heart failure,3 and adequate vitamin D may reduce disease progression and symptom severity through suppression of the renin-angiotensin-aldosterone system,3 suppression of parathyroid hormone,3 reduction of cardiac remodeling,4 and improvement in muscle strength.1 As an adjunct to pharmacological treatment of heart failure, vitamin D supplementation is appealing. Vitamin D can be obtained from sun exposure, over-the-counter dietary supplements, and prescription formulations. It has several potential additional benefits, including reducing the risk for falls, and few known adverse effects until high serum concentrations are reached (25-hydroxyvitamin D ?374 nmol/L).1
In this issue of Circulation: Heart Failure, Witham et al5 present the results of a randomized, double-blind, placebo-controlled trial testing the hypothesis that intermittent vitamin D supplementation improves physical function, as assessed with a 6-minute walk test, in older patients with systolic heart failure. Secondary outcomes include the timed up-and-go test, the Functional Limitation Profile, . . .
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
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