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COVID-19 might be treated with Mg IV and Potassium – July 2020

Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?

J Am Coll Nutr. 2020 Jul 10;1-9. doi: 10.1080/07315724.2020.1785971
Taylor C Wallace 1 2 3

VitaminDWiki

Magnesium and Vitamin D contains the following highlights

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Mg and Vitamin D

Dr. Dean

Number of studies in both of the categories of Magnesium and:

Bone 14,  Cardiovascular 13,   Diabetes 18. Depression 10,  Obesity 8,   Omega-3 22,  Zinc 16,  Pregnancy 7,  Headache 6

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Background: In December 2019, the viral pandemic of respiratory illness caused by COVID-19 began sweeping its way across the globe. Several aspects of this infectious disease mimic metabolic events shown to occur during latent subclinical magnesium deficiency. Hypomagnesemia is a relatively common clinical occurrence that often goes unrecognized since magnesium levels are rarely monitored in the clinical setting. Magnesium is the second most abundant intracellular cation after potassium. It is involved in >600 enzymatic reactions in the body, including those contributing to the exaggerated immune and inflammatory responses exhibited by COVID-19 patients.

Methods: A summary of experimental findings and knowledge of the biochemical role magnesium may play in the pathogenesis of COVID-19 is presented in this perspective. The National Academy of Medicine's Standards for Systematic Reviews were independently employed to identify clinical and prospective cohort studies assessing the relationship of magnesium with interleukin-6, a prominent drug target for treating COVID-19.

Results: Clinical recommendations are given for prevention and treatment of COVID-19. Constant monitoring of ionized magnesium status with subsequent repletion, when appropriate, may be an effective strategy to influence disease contraction and progression. The peer-reviewed literature supports that several aspects of magnesium nutrition warrant clinical consideration. Mechanisms include

  • its "calcium-channel blocking" effects that lead to downstream suppression of nuclear factor-Kβ, interleukin-6, c-reactive protein, and other related endocrine disrupters;
  • its role in regulating renal potassium loss; and
  • its ability to activate and enhance the functionality of vitamin D, among others.


Conclusion: As the world awaits an effective vaccine, nutrition plays an important and safe role in helping mitigate patient morbidity and mortality. Our group is working with the Academy of Nutrition and Dietetics to collect patient-level data from intensive care units across the United States to better understand nutrition care practices that lead to better outcomes.


Created by admin. Last Modification: Saturday July 11, 2020 14:26:01 GMT-0000 by admin. (Version 4)

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