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COPD lung volume reduction strongly associated with low vitamin D – March 2014

The Effect of Serum Vitamin D Level in Korean Chronic Obstructive Pulmonary Disease (COPD) Patients.

Chest. 2014 Mar 1;145(3 Suppl):388A. doi: 10.1378/chest.1826608.
Jung JY, Leem AY, Hwang ED, Kim SY, Kim SK, Chang J.

SESSION TITLE: COPD Comorbidity Posters
SESSION TYPE: Poster Presentations
PRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PM
PURPOSE: To determine the relationship of serum vitamin D level with lung function, acute exacerbation, 6 minute walking (6MW) distance, and quality of life.

METHODS:
Of Korean Obstructive Lung Disease cohort, 193 COPD patients with yearly measured serum vitamind D were enrolled in this analysis. Using the cluster analysis of repeatly measured serum vitamin D level with adjustment of age, sex, BMI, pack-years and smoking, the relationship of serum vitamin D level with lung function, acute exacerbation, 6 minute walking distance, and and quality of life were evaluated

RESULTS:
Among the 193 COPD patients, 12 (6.2%), 28 (14.5%), and 153 (79.3%) patients were categorized as normal (≥ 30ng/mL), insufficiency (≥ 20ng/mL, < 30ng/mL), and deficiency group (< 20ng/mL).
Clustered multivariate analysis showed that serum vitamin D level was related with

  • FEV1 (OR=0.01, P=0.006), FEV1% (OR=0.379, P=0.006),
  • FEV1/FVC % (OR=0.003, P=0.001),

but was not related with exacerbation (OR=0.988,P=0.391).
Six minutes walking distance was also associated with serum vitamin D level (estimated mean =1.26, P=0.055).
Dyspnea score after 6MW test decreased as serum vitamin D level increased (estimated mean = -0.037, P=0.018) while oxygen saturation after 6MW test increased as serum vitamin D level increased (estimated mean=0.104, P=0.033). However, no relationship was observed with St. George Respiratory Questionnaire scores.

CONCLUSIONS:
Serum vitamin D level is associated with lung function, physical activity, and dyspnea symptom after 6MW test in Korean COPD patients.

CLINICAL IMPLICATIONS:
Serum vitamin D level might affect the health status of Korean COPD patients.

DISCLOSURE:
The following authors have nothing to disclose: Ji Ye Jung, Ah Young Leem, Eu Dong Hwang, Song Yee Kim, Se Kyu Kim, Joon Chang No Product/Research Disclosure Information.

PMID: 24638545


FEV1 = Forced expiratory volume in one second

See also VitaminDWiki


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