Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study
European Journal of Epidemiology, pp 1–11
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
- Overview Fractures and vitamin D
Items in both categories Fractures/Falls and Magnesium are listed here:
- Fractures 1.5 X more-likely if low serum Magnesium – meta-analysis March 2023
- Bone fractures occurred twice as often if low Magnesium – April 2017
- Few Fractures if high Magnesium intake – 2X fewer for men, 2.6X for women – June 2017
- 20 percent fewer male hip fractures if more Magnesium in the water – July 2013
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Magnesium, which is an essential trace element that plays a key role in several cellular processes, is a major component of bone; however, its relationship with risk of major bone fractures is uncertain. We aimed to investigate the association of baseline serum magnesium concentrations with risk of incident fractures. We analyzed data on 2245 men aged 42–61 years in the Kuopio Ischemic Heart Disease prospective cohort study, with the assessment of serum magnesium measurements and dietary intakes made at baseline. Hazard ratios [95% confidence intervals (CI)] for incident total (femoral, humeral, and forearm) and femoral fractures were assessed. During a median follow-up of 25.6 years, 123 total fractures were recorded. Serum magnesium was non-linearly associated with risk of total fractures. In age-adjusted Cox regression analysis, the hazard ratio (HR) (95% CIs) for total fractures in a comparison of the bottom quartile versus top quartile of magnesium concentrations was 2.10 (1.30–3.41), which persisted on adjustment for several established risk factors 1.99 (1.23–3.24). The association remained consistent on further adjustment for renal function, socioeconomic status, total energy intake, and several trace elements 1.80 (1.10–2.94). The corresponding adjusted HRs for femoral fractures were 2.56 (1.38–4.76), 2.43 (1.30–4.53) and 2.13 (1.13–3.99) respectively. There was no evidence of an association of dietary magnesium intake with risk of any fractures. In middle-aged Caucasian men, low serum magnesium is strongly and independently associated with an increased risk of fractures. Further research is needed to assess the potential relevance of serum magnesium in the prevention of fractures.
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"Of the 22 men who had excess serum magnesium concentrations at baseline, none of them experienced a fracture at follow-up; "