Pulm Med. 2016;2016:1643717. Epub 2016 Oct 12.
Shaikh MN1, Malapati BR1, Gokani R2, Patel B3, Chatriwala M4.
1Department of Biochemistry, Parul Institute of Medical Science and Research (PIMSR), Limda, Waghodia, Gujarat 391760, India.
2Department of Biochemistry, C.U. Shah Medical Collage, Surendranagar, Gujarat, India.
3Department of Biochemistry, S.B.K.S MI & RC, Piparia, Vadodara, Gujarat 391760, India.
4Department of Biochemistry, Pramukhswami Medical College, Karamsad, Gujarat, India.
Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators.
| Vitamin D|
|Both hypomagnesemia |
and vitamin D deficiency
|Mild||14 %||21 %||100 %||7 %|
|Moderate||48 %||59 %||100 %||37 %|
|Severe||68 %||100 %||100 %||68 %|
Many diseases are associated with low Vitamin D AND/OR low Magnesium
Note: This study tested Magnesium blood levels,
rather than the more important Magnesium cell levels
Items in both categories Breathing and Magnesium are listed here:
- All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015
- Hypothesis: Magnesium accounts for some of the variation in vitamin D response – Oct 2013
- Magnesium and Vitamin D very synergistic – Aug 2013
- Magnesium is associated with prevention and treatment of Diabetes – Meta-analysis Aug 2016
- Acute Migraine 35 times more likely if low Magnesium levels – May 2016
- Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma.
Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects.
Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that.
Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.
PMID: 27818797 DOI: 10.1155/2016/1643717