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Arterial stiffness reduced if use at least 2,000 IU of Vitamin D for 4 months – meta-analysis Dec 2019

The Effects of Correction of Vitamin D Deficiency on Arterial stiffness: A Systematic Review and Updated Meta-analysis of Randomized Controlled Trials

The Journal of Steroid Biochemistry and Molecular Biology, https://doi.org/10.1016/j.jsbmb.2019.105561
Nai-ChingChenaChih-YangHsubfPili Chi-MingMaocGavinDreyerdFu-ZongWuefChien-LiangChenbf


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  • This meta‐analysis is examining the effect of nutrition vitamin D on vascular stiffness that is surrogates for cardiovascular events.
  • Correction of vitamin D deficiency by nutritional vitamin D may improve arterial stiffness.
  • Randomized controlled trials are needed to confirm whether these effects translate into improvements in cardiovascular morbidity and mortality in vitamin D deficient persons.

It is unclear whether nutritional vitamin D supplementation in vitamin D-deficient persons improves arterial stiffness. To conduct a meta-analysis of the effects of the nutritional vitamin D therapy on arterial stiffness in adults with vitamin D deficiency, the Scopus, PUBMED, EMBASE, and Cochrane databases were searched for systematic reviews conducted up to October 5, 2018. Randomized clinical trials that compared nutritional vitamin D therapy with placebo in adults with vitamin D deficiency were eligible. Two reviewers independently evaluated eligibility of all retrieved studies based on titles and abstracts. Meta-analysis was performed using random effect or fixed effects model and inverse variance method was used to calculate the effect using standardized mean difference (SMD) and weighted mean difference. A leave-one-out method was used for sensitivity analysis. The main outcome was arterial stiffness, indicated by the carotid-femoral pulse wave velocity (PWV). We identified 237 records, of which 9 satisfied the inclusion criteria of the study. Our meta-analysis included relatively high-quality placebo-controlled randomized trials. In a random-effects model, nutritional vitamin D was associated with significant reductions in the pooled difference of PWV [(SMD: -0.29; 95% CI: -0.51 to -0.06), p = 0.01; Cochran's Q test: chi2 = 21.85; df = 9; p = 0.009; I2 = 59%; n = 909 from 9 studies]. All sensitivity analyses yielded similar results. Nutritional vitamin D supplementation significantly improved arterial stiffness (PWV) in several subgroups by correcting vitamin D deficiency, for a study duration of ≥4 months and a daily dose of vitamin D3 ≥ 2000 IU.
The study indicated that the correction of vitamin D deficiency by nutritional vitamin D supplementation may improve arterial stiffness in vitamin D-deficient persons, especially by the correction of vitamin D deficiency with a daily dose of vitamin D3 ≥ 2000 IU. However, further studies are required to confirm this.

Created by admin. Last Modification: Monday December 9, 2019 21:11:12 GMT-0000 by admin. (Version 7)

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13128 PWV Meta.jpg admin 09 Dec, 2019 21:03 42.30 Kb 289
13126 Arterial stiffness meta Sci-Hub.pdf PDF 2019 admin 09 Dec, 2019 20:47 3.01 Mb 266
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