Supplementation with Three Different Daily Doses of Vitamin D3 in Healthy Pre-pubertal School Girls: A Cluster Randomized Trial
Indian Pediatrics, Nov 2018, Vol 55,Issue 11, pp 951–956 https://doi.org/10.1007/s13312-018-1416-z
RAMAN KUMAR MARWAHA1, A MITHAL2, NEETU BHARI3, G SETHURAMAN3, SUSHIL GUPTA4, MANOJ SHUKLA4,
ARCHANA NARANG 5, ADITI CHADDA5, NANDITA GUPTA6, V SREENIVAS7 AND MA GANIE6
From 1International Life Sciences Institute (India); 2Medanta Hospital Gurgaon, Haryana; Departments of 3Dermatology,
6Endocrinology and 7Biostatistics, AIIMS, New Delhi; 4SGPGI, Lucknow, Uttar Pradesh; and 5Dr BR Sur Homeopathic Medical
College, New Delhi; India.
Correspondence to: Maj Gen Raman Kumar Marwaha, Scientific Advisor (Projects), International Life Science Institute (India).
marwaha_ramank at hotmail.com.
Note: Most organization state that at least 30 ng is the goal, not just 20 ng
- Overview How Much vitamin D
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- Vitamin D consensus for Italian children, 30 ng needed, up to 4,000 IU if over age 10 – May 2018
- 10 Reasons why children no longer have healthy levels of Vitamin D
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015 Replete = 30 ng
- Why India's vitamin D deficiency is grim - 40 pages Feb 2014
PDF is available free at Sci-Hub 10.1007/s13312-018-1416-z
Objective: To compare the adequacy and efficacy of different doses of vitamin D3 in pre-pubertal girls.
Design: Cluster Randomized controlled trial.
Setting: Public school in Delhi, India, between August 2015 and February 2016.
Participants: 216 healthy pre-pubertal girls, aged 6.1-11.8 years.
Intervention: Daily supplementation with 600 IU (n=74), 1000 IU (n=67) or 2000 IU (n=75) of vitamin D3 under supervision for 6 months.
Outcome measures: Primary: Rise in serum 25 hydroxy Vitamin D (25(OH)D); Secondary: Change in bone formation and resorption markers.
Following 6 months of supplementation, the mean (SD) rise in serum 25(OH)D was maximum with 2000 IU (24.09 (8.28) ng/mL), followed by with 1000 IU (17.96 (6.55) ng/mL) and 600 IU (15.48 (7.00) ng/mL). Serum 25(OH)D levels of ≥20 ng/mL were seen in 91% in 600 IU group, 97% in 1000 IU group and 100% in 2000 IU group. The overall mean (SD) rise in urinary calcium creatinine ratio (0.05 (0.28) to 0.13 (0.12) mg/mg), and serum procollagen type I N-terminal propeptide (538.9 (199.78) to 655.5 (218.24) ng/mL), and reduction in serum carboxy-terminal telopeptide (0.745 (0.23) to 0.382 (0.23) ng/mL) was significant (P<0.01). The change in the above parameters was comparable among the three groups after adjustment for age.
Conclusion: Daily vitamin D supplementation with 600 IU to 2000 IU for 6 months results in Vitamin D sufficiency in >90% of prepubertal girls.