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Alemtuzumab treatment of autoimmune diseases has many side effects, Vitamin D should prevent most of them – June 2019

Vitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis

Therapeutics and Clinical Risk Management Volume 2019:15 Pages 891—904, DOI https://doi.org/10.2147/TCRM.S188941
Hans-Klaus Goischke
Independent Research, Internal Medicine, Rehabilitation Medicine, Social Medicine, Bad Brückenau, Bavaria, Germany

VitaminDWiki

Alemtuzumab appears to be a chemotherapy drug used to treat Multiple Sclerosis and various Cancers
Many of the diseases can be prevented and/or treated by Vitamin D without the use of Alemtuzumab


Overview MS and vitamin D contains the following summary

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

  • How much Vitamin D to prevent many diseases - such as MS
  • How much Vitamin D is needed to treat MS? There is currently no agreement
       The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
  • How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
       You must be under the supervision of a doctor who knows what to watch for in your individual situation.
       High doses of Vitamin D cannot be used as a monotherapy.
       You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
       Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3

 Download the PDF from VitaminDWiki

Purpose of review: Not only the multiple sclerosis specialist but also the general neurologist and primary care practitioner are increasingly aware of possible adverse events (AEs) by treatment with alemtuzumab (over 47% risk of secondary autoimmune-mediated diseases). Vitamin D supplementation’s effect (VDS) to reduce these autoimmune AEs is poorly performed in routine practice. This article seeks to justify why this simple, inexpensive, patient-friendly therapy should be seriously discussed.

Recent findings: Patients who have developed autoimmunity also show a high basal level of IL-21, a cytokine which increases the growth of auto-reactive T-cells.
For side effects such as

  • thyroid dysfunction,
  • autoimmune thrombocytopenia,
  • autoimmune hemolytic
  • anemia,
  • autoimmune hepatitis,
  • diabetes mellitus type 1, and
  • alopecia areata/alopecia totalis,

VDS may have an impact on the immunological mechanism, in particular lowering levels of IL-17 and IL-21.

Summary: The potential role of vitamin D in influencing autoimmune diseases is evident. If a life-threatening side-effect can be prevented by high-dose VDS, it is ethical to initiate this add-on therapy despite contradictory results in studies on the effectiveness of VDS.

Created by admin. Last Modification: Saturday July 13, 2019 11:41:44 GMT-0000 by admin. (Version 3)

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12318 alemtuzumab side effects.pdf PDF 2019 admin 13 Jul, 2019 11:37 254.64 Kb 33
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