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Air pollution associated with 45 percent increased risk of Vitamin D deficiency while pregnant – Aug 2019

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Some fraction of the reason for the decrease would be the women staying indoors more during times of high pollution

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Particulate Air Pollution Exposure and Plasma Vitamin D Levels in Pregnant Women: A Longitudinal Cohort Study

J of Clinical Endocrinology & Metabolism, V 104, Issue 8, Pages 3320–3326, https://doi.org/10.1210/jc.2018-02713
Yan Zhao Lei Wang Hongjiao Liu Zhijuan Cao Xiujuan Su Jing Cai Jing Hua

Context: No studies have assessed the association between air pollution exposure and vitamin D status in pregnant women.

Objective: To examine the association between particulate air pollution exposure and circulating 25-hydroxyvitamin 25(OH)D levels in pregnant women.

Design: A longitudinal cohort study.

Participants: A total of 3285 pregnant women were recruited at a maternal and child health hospital.

Interventions: None.

Main Outcome Measures: Serum 25(OH)D levels.

Results
We observed trimester-specific associations between particulate air pollution exposure and circulating 25(OH)D levels. The associations were most pronounced for the periods of the third trimester and the entire pregnancy. A 10 μg/m3 increase in fine particulate matter (PM2.5) and particulate matter with aerodynamic diameter ≤10 μm (PM10) exposure during the entire pregnancy was associated with a 4.62% (95% CI, −6.31% to −2.93%) and 5.06% (95% CI, −6.50% to −3.62%) decrease in 25(OH)D levels, respectively. Particulate air pollution exposure was also associated with elevated odds of maternal vitamin D deficiency.
A 10 μg/m3 increase in PM2.5 and PM10 exposure during the entire pregnancy was associated with a

  • 45% (OR = 1.45, 95% CI, 1.29 to 1.63) and
  • 48% (OR = 1.48, 95% CI, 1.33 to 1.64) increase in the odds of maternal vitamin D deficiency.

Mediation analysis estimated that decreased solar UV-B radiation mediated 69.5% and 66.4% of the inverse association between PM2.5 and PM10 exposure and circulating 25(OH)D levels.

Conclusion
Our results suggest that prenatal exposure to particulate air pollution may play an independent role in maternal vitamin D deficiency. The role of air pollution should be incorporated into future guidelines for the prevention of maternal vitamin D deficiency.


Created by admin. Last Modification: Tuesday June 25, 2019 20:28:45 GMT-0000 by admin. (Version 3)

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12205 Air pollution pregnancy.pdf PDF 2019 admin 25 Jun, 2019 20:27 589.08 Kb 228
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