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After HIV infection, Vitamin D levels drop for years (not a surprise)– Oct 2021

The association between serum vitamin D and body composition in South African HIV-infected women

South Afr J HIV Med. 2021 Sep 30;22(1):1284. doi: 10.4102/sajhivmed.v22i1.1284
Samuel Mwango 1, Janet Carboo 1, Christa Ellis 1, Marike Cockeran 2, Carina M C Mels 3 4, Herculina S Kruger 1 4

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VitaminDWiki

HIV category listing contains the following

45 HIV items   see also: Overview HIV and vitamin D   Immunity category: 262 items

Pregnant women in HIV therapy adding Vitamin D had 3X fewer deaths - RCT April 2022
HIV treatment augmented by high-dose vitamin D, daily or weekly – Dec 2021
Low vitamin D with HIV increases risk of infections – TB by 3.5X, CMV by 10.1X – Aug 2020
HIV therapy reduces Vitamin D levels, supplementation helps - Nov 2019
Cognitive problems 2X more likely if HIV and low vitamin D – June 2019
Use of Tenofovir disoproxil fumarate (Hepatitis-B, AIDS) requires more vitamin D – Sept 2018
Vertebral fractures 9X more likely in HIV patients having low vitamin D – Dec 2017
HIV patients helped by monthly 120,000 IU of Vitamin D – RCT Oct 2017
Those with HIV who doubled their vitamin D levels reduced their chance of death by 47 percent – Oct 2013
A gut-friendly form of vitamin D should be used for those with HIV and gut problems
   Alternately, just use 2X to 3X more vitamin D than for a person who has a good gut
3X more African girls and women have HIV than African males Washington Post Dec 2023
  Note: Many women have lower vitamin D levels than men due to hormones and not being outdoors as much
  In addition, dark-skinned women often avoid the sun due to a desire to have a lighter skin shade


Many potential reasons for the decrease in vitamin D levels with HIV
1) HIV therapy drugs
2) Indoors more with HIV
3) Worse gut, so vitamin D less available
4) Fighting the virus consumes vitamin D
   It is very important to restore vitamin D levels to avoid getting addiitonal health problems

 Download the PDF from VitaminDWiki

Background: HIV and antiretroviral therapy (ART) alter vitamin D metabolism, and may be associated with bone loss.

Objectives: The aim of this study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) and body composition in postmenopausal South African women living with HIV and on ART.

Method: In this 2-year longitudinal study on 120 women conducted in the North West province of South Africa, serum 25(OH)D concentration, bone mineral density (BMD) at three sites, lean mass and percentage of body fat (%BF) were measured by dual-energy X-ray absorptiometry (DXA). Multivariable linear mixed models were used to assess the association between serum 25(OH)D and body composition over 2 years. Linear mixed models were also used to determine the longitudinal association between lean mass, %BF and BMD.

Results: Vitamin D deficiency and insufficiency increased from baseline (10.2% and 19.5%) to 11.5% and 37.5%, respectively, after 2 years. Serum 25(OH)D decreased significantly, however, with a small effect size of 0.39 (P = 0.001), whilst total BMD (effect size 0.03, P = 0.02) and left hip femoral neck (FN) BMD (effect size 0.06, P = 0.0001) had significant small increases, whereas total spine BMD did not change over the 2 years. Serum 25(OH)D had no association with any BMD outcomes. Lean mass had a stronger positive association with total spine and left FN BMD than %BF.

Conclusion: Serum 25(OH)D was not associated with any BMD outcomes. Maintenance of lean mass could be important in preventing bone loss in this vulnerable group; however, longer follow-up may be necessary to confirm the association.


Created by admin. Last Modification: Tuesday October 26, 2021 15:02:26 GMT-0000 by admin. (Version 8)

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16494 HIV year 1.jpg admin 26 Oct, 2021 59.55 Kb 176
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