Vitamin D Deficiency and Acute Lower Respiratory Infections in Children Younger Than 5 Years: Identification and Treatment
Journal of Pediatric Health Care, Volume 28, Issue 6, November–December 2014, Pages 572–582
Allison Larkin, MS, NP-C, , Jane Lassetter, PhD, RN
Acute lower respiratory infection (ALRI) is a leading cause of childhood mortality. Research suggests that vitamin D deficiency (VDD) puts children at risk for ALRI. The purpose of this review is to examine ALRI and VDD in children 5 years and younger. Common etiologies, diagnosis, prevention, treatment of ALRI, and recommendations for vitamin D supplementation are summarized.
Databases were searched for studies investigating VDD and ALRI in children. Independent reviewers assessed the internal validity of the studies.
Of 18 studies examined, VDD was found to be associated with increased risk or severity of ALRI in 13 studies; associations were not found in 4 studies. In one study it was found that high maternal vitamin D levels was associated with ALRI in infants.
Vitamin D supplementation is a low-cost, low-risk intervention that providers should consider for children, especially those at high risk for ALRI. Practitioners should follow current recommendations when prescribing vitamin D supplementation for infants and children.
- Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012
- Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 infants
- Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012
- Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015
- Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis May 2010
Free PDF on-line. One of the causes of ALRI is a virus
Pneumonia "is life-threatening in the elderly or those who are immunocompromised" Wikipedia
- Effect of Vitamin D3 Supplementation on Respiratory Tract Infections in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Sept 2016
appears that none of the trials used > 2,000 IU daily
Download the PDF from VitaminDWiki