Loading...
 
Translate Register Log In Login with facebookLogin and Register

Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014

Electromechanical effects of 1,25-dihydroxyvitamin d with antiatrial fibrillation activities.

J Cardiovasc Electrophysiol. 2014 Mar;25(3):317-23. doi: 10.1111/jce.12309. Epub 2013 Nov 14.
Hanafy DA1, Chang SL, Lu YY, Chen YC, Kao YH, Huang JH, Chen SA, Chen YJ.

INTRODUCTION:
Treatment with 1,25-dihydroxyvitamin D (1,25[OH]2 D) has several cardiovascular benefits. 1,25[OH]2 D has direct cellular effects, but its effects on the atrium are not clear. We evaluated the effects of 1,25[OH]2 D on the atrial electrophysiology and atrial fibrillation (AF).

METHODS:
Conventional microelectrodes were used to record action potentials (APs) and contractility in isolated rabbit left atrium (LA) tissue preparations before and after the administration of 0.01, 0.1, and 1 nM 1,25[OH]2 D with and without rapid atrial pacing (RAP) and acetylcholine (5 mM)-induced AF. Surface ECG and intracardiac electrograms were recorded before and after the intravenous administration of 4 units/kg of 1,25[OH]2 D in heart failure (HF) rabbits (4 weeks after coronary artery ligation) with RAP and acetylcholine-induced AF.

RESULTS:
1,25[OH]2 D dose-dependently increased the AP duration in the LA, which was abolished by pretreatment with 0.1 μM ryanodine. RAP and 5 mM acetylcholine-induced fewer (64.3% vs 100%, P < 0.05) AF occurrences in the presence (n = 14) of 1,25[OH]2 D than those (n = 14) in the absence of 1,25[OH]2 D. The LA treated with 1,25[OH]2 D (n = 9) had a slower maximal AF rate (10.9 ± 2.4 Hz vs 13.3 ± 2.7 Hz, P < 0.05) than the LA (n = 14) without 1,25[OH]2 D. Moreover, 1,25[OH]2 D caused a lower AF inducible percentage (11.0 ± 1.9% vs 100 ± 0%, P < 0.001) and a shorter duration (4 ± 0.4 seconds vs 309 ± 26 seconds, P < 0.001) with a prolonged LA 90% monophasic AP duration (94.1 ± 0.2 milliseconds vs 98.5 ± 0.1 milliseconds, P < 0.05) in 5 rabbits with HF. 1,25[OH]2 D did not prolong the QT interval or 90% of the AP duration in isolated Purkinje fibers.

CONCLUSION:
1,25[OH]2 D has direct electromechanical effects on the LA and can prevent or terminate AF.

Can rent for $6: 2013 Wiley Periodicals, Inc.

PMID: 24152033


See also VitaminDWiki

See any problem with this page? Report it (FINALLY WORKS)