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ALS reduction far more likely if take Curcumin, Luteolin, CBD, Omega-3, or Vitamin D etc – April 2018

"ALS reversals": demographics, disease characteristics, treatments, and co-morbidities.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Apr 2:1-5. doi: 10.1080/21678421.2018.1457059. [Epub ahead of print]
Harrison D1, Mehta P2, van Es MA3, Stommel E4, Drory VE5, Nefussy B5, van den Berg LH3, Crayle J1, Bedlack R6; Pooled Resource Open-Access ALS Clinical Trials Consortium.

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>100X more likely to have "ALS Reversal" with various supplements

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OBJECTIVE:
To identify differences in demographics, disease characteristics, treatments, and co-morbidities between patients with "amyotrophic lateral sclerosis (ALS) reversals" and those with typically progressive ALS.

METHODS:
Cases of possible ALS reversals were found in prior publications, in the Duke ALS clinic, through self-referral or referral from other Neurologists, and on the internet. Of 89 possible reversals identified, 36 cases were included because chart or literature review confirmed their diagnosis and a robust, sustained improvement in at least one objective measure. Controls were participants in the Pooled Resource Open-Access ALS Clinical Trials database and the National ALS Registry. Cases and controls were compared using descriptive statistics.

RESULTS:
ALS reversals were more likely to be male, have limb onset disease, and initially progress faster. The prevalences of myasthenia gravis (MG) and purely lower motor neuron disease in cases were higher than estimates of these prevalences in the general population. The odds of taking

  • curcumin,
  • luteolin,
  • cannabidiol,
  • azathioprine,
  • copper,
  • glutathione,
  • vitamin D, and
  • fish oil

were greater for cases than controls.

CONCLUSIONS:
When compared to patients with typically progressive ALS, patients with reversals differed in their demographics, disease characteristics, and treatments. While some of these patients may have had a rare antibody-mediated ALS mimicker, such as atypical myasthenia gravis, details of their exams, EMGs and family histories argue that this was unlikely. Instead, our data suggest that ALS reversals warrant evaluation for mechanisms of disease resistance and that treatments associated with multiple ALS reversals deserve further study.

PMID: 29607695 DOI: 10.1080/21678421.2018.1457059


Created by admin. Last Modification: Saturday April 20, 2019 19:17:03 GMT-0000 by admin. (Version 7)

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ID Name Comment Uploaded Size Downloads
9631 ALS reversals supp Table 3.jpg admin 03 Apr, 2018 14:32 48.28 Kb 1168
9630 ALS reversals supplement.pdf admin 03 Apr, 2018 14:31 118.12 Kb 292
9629 ALS reversals.pdf PDF 2018 admin 03 Apr, 2018 14:16 592.88 Kb 143
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