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60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018

Vitamin D and Its Role in Neonatal Hypoxic-Ischemic Brain Injury

Neonatology 2018;113:305–312, https://doi.org/10.1159/000486819
Stessman L.E. · Peeples E.S.


This study speculates as to how much Vitamin D should be given during pregnancy to reduce HIE

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Infant Hypoxic Ischemic Encephalopathy (HIE)

  • "Hypoxic Ischemic Encephalopathy (HIE) is a type of brain damage that occurs when an infant’s brain doesn’t receive enough oxygen and blood."
  • " the incidence rate in premature babies is 60% of all live births"
    The word vitamin does not occur once on that page

Hypoxic-Ischemic Encephalopathy Medscape Jan 2018

  • "Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia"
  • "Birth asphyxia causes 840,000 or 23% of all neonatal deaths worldwide"

Hypoxic-Ischemic Encephalopathy, or HIE, also known as Intrapartum Asphyxia Cerebralpalsy.org

  • "Oxygen deprivation, or intrapartum asphyxia, can cause Cerebral Palsy. One of the most common types of brain damage caused by oxygen loss is called hypoxic-ischemic encephalopathy, or HIE. When HIE occurs, it often leads to severe developmental or cognitive delays, or motor impairments that become more apparent as the child continues to develop"


Emerging evidence has demonstrated that vitamin D plays an important role in many adult neurologic disorders, but is also critical in neuronal development and pruning in the neonatal and pediatric populations. Neonates are at a particularly high risk of vitamin D deficiency, in part due to the high prevalence of maternal deficiency during pregnancy. Several preclinical studies have demonstrated that infants born to vitamin D-deficient mothers are at a high risk of developing neonatal brain injury, and recent clinical studies have shown that neonates with hypoxic-ischemic encephalopathy (HIE) tend to be vitamin D-deficient. There are limited data, however, on whether additional prenatal or postnatal supplementation may alter the prevalence or severity of neonatal HIE. This review examines the current data supporting the neuroprotective role of vitamin D, with a focus on how these findings may be translated to neonates with HIE.

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Created by admin. Last Modification: Thursday February 22, 2018 00:00:43 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
9386 HIE Fig 4.jpg admin 21 Feb, 2018 40.54 Kb 648
9385 HIE.pdf admin 21 Feb, 2018 249.95 Kb 701