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500 mg of Magnesium for 8 weeks increased Vitamin D about 30 pcnt – RCT July 2020

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

Nutrients 2020, 12(8), 2283; https://doi.org/10.3390/nu12082283
by Héctor Vázquez-Lorente 1,*OrcID,Lourdes Herrera-Quintana 1,Jorge Molina-López 2OrcID,Yenifer Gamarra-Morales 1,*,Beatriz López-González 1,Claudia Miralles-Adell 1 andElena Planells 1

  • 1 Department of Physiology, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, 18071 Granada, Spain
  • 2 Department of Physical Education and Sports, Faculty of Education, Psychology and Sports Sciences, University of Huelva, 21007 Huelva, Spain

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Menopause is a stage of hormonal imbalance in women which, in addition to other physiopathological consequences, poses a risk of deficiency of key micronutrients such as magnesium and vitamin D. A study was made of the influence of a magnesium intervention upon vitamin D status in a postmenopausal population from the province of Granada (Spain). Fifty-two healthy postmenopausal women between 44–76 years of age were included. Two randomized groups—placebo and magnesium (500 mg/day)—were treated during eight weeks. Nutrient intake was assessed using questionnaires based on 72-h recall. Vitamin D was analyzed by liquid chromatography—tandem mass spectrometry. Baseline vitamin D proved deficient in over 80% of the subjects. The administration of magnesium resulted in significantly increased vitamin D levels in the intervention group versus the controls (p < 0.05). Magnesium supplementation improved vitamin D status in the studied postmenopausal women.

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