The Effects of Vitamin D Supplementation and 25-Hydroxyvitamin D Levels on the Risk of Myocardial Infarction and Mortality
J Endocr Soc. 2021 Jul 15;5(10):bvab124. doi: 10.1210/jendso/bvab12
Prakash Acharya 1, Tarun Dalia 1, Sagar Ranka 1, Prince Sethi 1, Olurinde A Oni 2, Maya S Safarova 1, Deepak Parashara 1 2 3, Kamal Gupta 1, Rajat S Barua 1 2 3
No indication of dose size prescribed nor for how long
20,000 patient records spanning 19 years
They noticed that those whose vitamin D levels were raised from were 40% more likely to not die
They discarded the data from those whose values dropped back to less than 20 ng
VA appears to have a policy of prescribing Vitamin D if < 20 ng
It appears that VA learned that they might save money if they increased Vitamin D
Click on image to see study from 2012
Mortality starts with:
{FONT(size="18")} People die sooner if they have low vitamin D{FONT}
{img fileId="2699" width ="450" link="People die sooner if they have low vitamin D – Nov 2014"}
click on image for details
- More vitamin D means fewer deaths – many studies
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Senior women having low vitamin D were 2X more likely to die - Sept 2023
- Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017
There are {SQL(db=>vitamind)}SELECT COUNT(*) FROM `tiki_category_objects` WHERE `categId`=30{SQL} articles in Mortality category
{DIV(class="lefth4")}LECT catObjectId, COUNT(*) FROM `tiki_category_objects` WHERE categId = 30 OR categId = 82 GROUP BY catObjectId HAVING COUNT(*) > 1) AS categs INNER JOIN tiki_objects ON tiki_objects.objectId = categs.catObjectId WHERE type = "wiki page"{SQL} Mortality Meta-analyses
This list is automatically updated
{category id="30+82" types="wiki" sort="created_desc" split="n" and="y" sub="n" showdescription="n" showname="y" showtype="n" one="y" showTitle="n"}
{FONT(size="17")} See also in VitaminDWiki{FONT}
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Senior women having low vitamin D were 2X more likely to die - Sept 2023
- Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017
Likewise higher D ==> less COVID death - perhaps >40 ng is needed for COVID
- COVID-19 mortality was associated with vitamin D deficiency of 47 countries – July 2021
- COVID-19 death in hospital 5X more likely if low vs high vitamin D – preprint June 2021
- COVID-19 deaths 1.5X less likely if more than 40 ng of vitamin D – US VA – April 2021 Note: VA
- Risk of COVID-19 death was 4.9 X higher if very low vitamin D – March 31, 2021
- Poor COVID-19 prognosis was 6 X more likely if low vitamin D – Jan 21, 2021
Download the PDF from VitaminDWiki
Objective: The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D-deficient patients without a prior history of myocardial infarction (MI).
Materials and methods: This was a retrospective, observational, nested case-control study of patients (N = 20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (<20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups:
- Group A (untreated, levels ≤20 ng/mL),
- Group B (treated, levels 21-29 ng/mL), and
- Group C (treated, levels ≥30 ng/mL).
The risk of MI and all-cause mortality were compared utilizing propensity score-weighted Cox proportional hazard models.
Results: Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B (hazard ratio [HR] 0.65, 95% CI 0.49-0.85, P = .002) and Group A (HR 0.73, 95% CI 0.55-0.96), P = .02). There was no difference in the risk of MI between Group B and Group A (HR 1.14, 95% CI 0.91-1.42, P = 0.24).
Compared with Group A, both
- Group B (HR 0.59, 95% CI 0.54-0.63, P < .001) and
- Group C (HR 0.61, 95% CI 0.56-0.67, P < .001)
had significantly lower all-cause mortality.
There was no difference in all-cause mortality between Group B and Group C (HR 0.99, 95% CI 0.89-1.09, P = .78).
Conclusions: In patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of >20 ng/mL and >30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels ≥30 ng/mL.
Short URL= https://is.gd/acharya2021