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3X more bio-markers of poor immune system (Antinuclear Antibodies) if low Vitamin D – Dec 2016

Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults.

Cancer Epidemiol Biomarkers Prev. 2016 Dec;25(12):1559-1563. Epub 2016 Aug 19.
Meier HC1, Sandler DP2, Simonsick EM3, Parks CG4.

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ANA varies with race: :Low is < 10 ng/ml
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BACKGROUND:
Vitamin D deficiency is associated with cancer and autoimmune diseases, but little is known about the association between vitamin D and antinuclear antibodies (ANA), a biomarker of immune dysfunction in healthy populations. The objective of this study was to determine whether vitamin D deficiency is associated with ANA in middle-aged and older U.S. adults.

METHODS:
A cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) 2001-2004 was conducted. Data were available for 1,012 adults aged 50 years and older. Serum 25-hydroxyvitamin D levels were measured by radioimmunoassay. ANA was measured in a 1:80 dilution of sera by immunofluorescence using HEp-2 cells (seropositive = 3 or 4+).

RESULTS:
Greater vitamin D deficiency was associated with higher ANA prevalence in the unadjusted (Ptrend = 0.0002) logistic regression model and after adjustment for sex, age, education, race/ethnicity, season, and NHANES cycle (Ptrend = 0.04). After adjustment, those with severe vitamin D deficiency (<10 ng/mL) had 2.99 (95% CI, 1.25-7.15) times the odds of ANA compared with having normal vitamin D levels (≥30 ng/mL), while deficient and insufficient individuals had twice the odds of ANA.

CONCLUSIONS:
Among U.S. residents ages 50 and older, vitamin D deficiency was associated with higher prevalence of ANA. Vitamin D sufficiency may be important for preventing immune dysfunction in older populations.

IMPACT:
Our findings support the growing evidence that vitamin D is an important immune modulator. Vitamin D deficiency in older adults may increase vulnerability to cancer by contributing to immune dysfunction. Cancer Epidemiol Biomarkers Prev; 25(12); 1559-63. ©2016 AACR.

©2016 American Association for Cancer Research.

PMID: 27543618 PMCID: PMC5135624 DOI: 10.1158/1055-9965.EPI-16-0339


Created by admin. Last Modification: Tuesday February 27, 2018 12:04:27 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
9420 ANA Race.jpg admin 27 Feb, 2018 19.23 Kb 580
9419 ANA.jpg admin 27 Feb, 2018 29.88 Kb 585
9418 Vitamin D Deficiency and Antinuclear Antibodies.pdf admin 27 Feb, 2018 471.09 Kb 523