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36% of Multiple Sclerosis patients got worse after mild to severe COVID– June 2022


Mult Scler Relat Disord. 2022 Jun 6;63:103946. doi: 10.1016/j.msard.2022.103946
Sarah E Conway 1, Brian C Healy 2, Jonathan Zurawski 1, Christopher Severson 1, Tamara Kaplan 1, Lynn Stazzone 1, Kristin Galetta 1, Tanuja Chitnis 1, Maria K Houtchens 3

36% got worse

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Trends: Take more vitamin D ==> fewer COVID problems

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Background: Neurologic outcomes in patients with multiple sclerosis (MS) and related disorders (MSRD) following COVID-19 is not well understood. The objective of this study was to investigate neurologic outcomes in patients with MSRD post-COVID-19.

Methods: This was a retrospective medical records review study of adult patients with MSRD and COVID-19 infection at the Brigham MS Center. Neurologic worsening post-COVID-19 was defined as having a relapse, pseudorelapse, new brain MRI activity, worsening of preexisting MSRD symptoms, or development of other long-term neurologic symptoms.

Results: 111 patients, 85 (76.6%) females, with a mean [SD] age of 49.3 [12.2] years and median [range] EDSS of 2.5 [0, 8.5] were identified. 41 patients (36.9%) had neurologic worsening post-COVID-19. Of those, 19 (46.3%) had pseudorelapses, 2 (4.8%) had relapses, and 24 (58.5%) patients reported worsening of preexisting MSRD symptoms, or other new long-term neurologic symptoms. Neurologic worsening was associated with hospitalized (moderate or severe) COVID-19 (p = 0.001), treatment for COVID-19 (p = 0.006), and incomplete COVID-19 recovery (p = 0.0267) but not with age, sex, MS type, race, disease duration, EDSS, vitamin D use, or disease modifying therapy use.

Conclusions: COVID-19 severity and lack of complete systemic recovery were associated with new or worsening neurologic symptoms in 36.9% of MSRD patients.
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Created by admin. Last Modification: Friday June 17, 2022 12:04:24 GMT-0000 by admin. (Version 7)

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