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30 percent fewer infections of middle ear (otitis media) with 1000 IU of vitamin D – RCT May 2013

Vitamin D Supplementation Reduces the Risk of Acute Otitis Media in Otitis-Prone Children.

Pediatr Infect Dis J. 2013 May 20.
Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, Terranova L, Tirelli S, Esposito S, Principi N.

  • 1 Pediatric Clinic 1, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy;
  • 2 Epidemiology Unit, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; 3Laboratory Medicine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

BACKGROUND: The aim of this study was to evaluate whether a deficit in vitamin D (VD) is associated with an increased risk of recurrent acute otitis media (rAOM), and whether VD supplementation is effective in reducing the number of AOM episodes in otitis-prone children.

METHODS: A total of 116 children with a history of rAOM (≥3 episodes in preceding six months, or ≥4 episodes in preceding 12 months) were prospectively and blindly randomized to receive oral VD 1,000 IU/day or placebo for 4 months. Episodes of AOM were monitored for 6 months.

RESULTS: Fifty-eight children received placebo and 58 with similar characteristics were treated with VD. The number of children experiencing ≥1 AOM episode during the study period was significantly lower in the treatment group (26 vs 38; p=0.03). There was a marked difference in the number of children who developed uncomplicated AOM (p<0.001), but no difference in the number of children with ≥1 episode of spontaneous otorrhea. The likelihood of AOM was significantly reduced in the patients whose serum VD concentrations were ≥30 ng/mL.

CONCLUSIONS: VD hypovitaminosis is common in children with rAOM and associated with an increase in the occurrence of AOM when serum 25(OH)D levels are <30 ng/mL. The administration of VD in a dosage of 1,000 IU/day restores serum values of ≥30 ng/mL in most cases and is associated with a significant reduction in the risk of uncomplicated AOM.

PMID: 23694840

8 minute video by one of the authors

See also VitaminDWiki

Summary by VitaminDWiki

  • 58 pairs of children who tended to get middle ear infection
  • 26 got infection with vitamin D
  • 38 got infection with placebo
  • Thus ~ 30% reduction in middle ear infection with 1,000 IU of vitamin D

Comment by VitaminDWiki: Even fewer ear infections if had

  • Started with a loading dose, thus eliminating about 3 months of ear infections. (guess 45% instead of 30%)
  • Used a large dose of vitamin D (guess 70% if had used 2,000 IU of vitamin D)
  • Focused on high-risk children: dark skins. high latitude, etc. (guess 70% instead of 30%)

See also web


13% less likely to get COME for each 4 ng higher level of Vitamin D - Sept 2017

Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study.
Acta Paediatr. 2017 Sep;106(9):1487-1492. doi: 10.1111/apa.13908. Epub 2017 Jun 9.
Walker RE1, Bartley J2, Camargo CA Jr3,4, Flint D2, Thompson JMD1, Mitchell EA1.

Vitamin D supplementation and higher 25(OH)-vitamin D concentration are associated with reduced risk of acute respiratory infection. This study examined whether there is a similar association between higher serum 25(OH)D concentration and lower risk of chronic otitis media with effusion (COME).

In a case-control study, serum 25(OH)D concentration in children referred for tympanostomy tube placement for COME (n = 178) was compared to that of healthy children randomly sampled from primary care practices (n = 179). Subjects aged three and four years were recruited in Auckland, New Zealand between May 2011 and November 2013. Blood samples were collected from the children, and their guardians were interviewed. Odds ratios were calculated using logistic regression.

In a multivariable analysis, higher serum 25(OH)D concentration was associated with a lower risk of COME (OR: 0.86 per 10 nmol/L; 95% CI 0.77-0.97) after adjusting for age, sex, deprivation index, ethnicity, tobacco smoke exposure, duration of breastfeeding and season of blood sampling. Further adjustment for eight additional risk factors did not change the result.

This finding supports further investigation into whether the risk of COME could be reduced by increasing serum 25(OH)D concentration through increased sun exposure, higher dietary intake or vitamin D supplementation.

Attached files

ID Name Comment Uploaded Size Downloads
7857 Otitis Media.jpg admin 19 Mar, 2017 03:15 24.50 Kb 437
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