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25 minutes of daily sun provided less than half of the response as 500 IU of vitamin D (Korea) – RCT March 2019

Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial

Hee-Kyung Joha,b,c, Hee-Kyung Joh Hee-Kyung Joh, Hwang Seung-sikd, Be Long Chob,e,f,g, Chun Soo Limh, Sung-Eun Jungi
DOI: https://doi.org/10.1016/j.clnu.2019.03.021

VitaminDWiki

No – 10 minutes per day of sun-UVB is NOT enough contains the following summary


Note: The abstract does not indicate

  1. amount of clothing worn
  2. the season of the year - hopeuflly summer
  3. standing vs lying down - can be a 4X differ4ence
  4. Age of adult - can be a 4X difference
  5. % of the days were cloudy ( ~3X reducion on cloudy days)
  6. % of compliance "compliance relatively low"

 Download the PDF from Sci-Hub via VitaminDWiki

Sun was only slightly better than placebo

Image

Background
Vitamin D inadequacy is associated with a wide range of diseases. However, optimal strategies to improve vitamin D status, especially in Asian populations, remain unclear. We tested the hypotheses that (1) relevant sun exposure or oral vitamin D supplementation would significantly increase serum 25-hydroxyvitamin D (25OHD) concentrations compared with placebo, (2) sun exposure and supplementary vitamin D would be similar in serum 25OHD increases, and (3) the two interventions may have different effects on cardio-metabolic markers.

Methods
In this 8-week randomized placebo-controlled clinical trial including vitamin D-deficient adults in Seoul (37 °N), Korea, changes in serum 25OHD concentrations were compared between the sun exposure (daily ≥ 20–30 minutes around noon, n = 50), oral vitamin D3 (500 IU/d, n = 50), and control (placebo, n = 50) groups.

Results
Both sun exposure and oral vitamin D3 effectively increased serum 25OHD concentrations. Compared with placebo, the between-group least-squares mean (LSM) differences in changes were 2.2 ng/mL (95% CI: 0.2, 4.2) in the sun exposure group and 8.5 ng/mL (6.5, 10.5) in the oral vitamin D3 group. Increases in serum 25OHD were greater with oral vitamin D3 than with sun exposure (LSM difference in changes = 6.3 ng/mL, 95% CI: 4.3, 8.3). More participants in the oral vitamin D3 group (54.2%) achieved serum 25OHD concentrations ≥ 20 ng/mL at week 8 than those in the sun exposure (12.2%) or control (4.3%) groups. Compliance with sun exposure advice was relatively low, and only those with adequate compliance had a significant increase in serum 25OHD. Changes in the cardio-metabolic markers were mostly insignificant in all groups.

Conclusions
Enhanced sun exposure and 500 IU/d of oral vitamin D3 supplementation significantly increased serum 25OHD concentrations. However, our protocol for sun exposure was not as effective as 500 IU/d of oral vitamin D3 supplementation.

This trial was registered at clinicaltrials.gov as NCT03310242.


Created by admin. Last Modification: Monday April 1, 2019 21:12:28 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
11701 UV vs sun 25 minute.pdf admin 01 Apr, 2019 660.47 Kb 672
11668 25 min vs 500 IU.jpg admin 26 Mar, 2019 11.84 Kb 520