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11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013

Vitamin D insufficiency is associated with challenge-proven food allergy in infants

Journal of Allergy and Clinical Immunology. Available online 27 February 2013
Katrina J. Allen, MBBS, BMedSc, FRACP, PhDa, b, c, katie.allen at rch.org.au
Jennifer J. Koplin, PhDa, b, ∗, Anne-Louise Ponsonby, MBBS, PhDa, b, Lyle C. Gurrin, PhDa, d,
Melissa Wake, MD, FRACPa, b, e, Peter Vuillermin, MBBS, FRACP, PhDa, f, Pamela Martin, PhDa,
Melanie Matheson, PhDd, Adrian Lowe, PhDa, d, Marnie Robinson, MBBS, FRACPc,
Dean Tey, MBBS, FRACPc, Nicholas J. Osborne, PhDa, b, d, g, Thanh Dang, BSca,
Hern-Tze Tina Tan, BSca, Leone Thiele, BA, MNSca, Deborah Anderson, RNa,
Helen Czech, RNa, Jeeva Sanjeevan, MBBSa, Giovanni Zurzolo, BSca,
Terence Dwyer, PhDa, Mimi L.K. Tang, MBBS, FRACP, FRCPA, PhDa, b, c, David Hill, MBBD, FRACPa,
Shyamali C. Dharmage, MBBS, MSc, MD, PhDa, d
a Murdoch Childrens Research Institute, Parkville, Victoria
b Department of Paediatrics, The University of Melbourne, Parkville, Victoria
c Department of Allergy and Immunology, The Royal Children’s Hospital, Parkville, Victoria
d Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria
e Centre for Community Child Health, The Royal Children’s Hospital, Parkville, Victoria
f Child Health Research Unit, Barwon Health and Deakin University, Geelong, Victoria
g European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom

Background: Epidemiological evidence has shown that pediatric food allergy is more prevalent in regions further from the equator, suggesting that vitamin D insufficiency may play a role in this disease.

Objective: To investigate the role of vitamin D status in infantile food allergy.

Methods: A population sample of 5276 one-year-old infants underwent skin prick testing to peanut, egg, sesame, and cow’s milk or shrimp. All those with a detectable wheal and a random sample of participants with negative skin prick test results attended a hospital-based food challenge clinic. Blood samples were available for 577 infants (344 with challenge-proven food allergy, 74 sensitized but tolerant to food challenge, 159 negative on skin prick test and food challenge). Serum 25-hydroxyvitamin D levels were measured by using liquid chromatography tandem mass spectrometry. Associations between serum 25-hydroxyvitamin D and food allergy were examined by using multiple logistic regression, adjusting for potential risk and confounding factors.

Results: Infants of Australian-born parents, but not of parents born overseas, with vitamin D insufficiency (≤50 nmol/L) were more likely to be

  • peanut (adjusted odds ratio [aOR], 11.51; 95% CI, 2.01-65.79; P = .006)
  • and/or egg (aOR, 3.79; 95% CI, 1.19-12.08; P = .025)

allergic than were those with adequate vitamin D levels independent of eczema status.
Among those with Australian-born parents, infants with vitamin D insufficiency were more likely to have multiple food allergies (≥2) rather than a single food allergy (aOR, 10.48; 95% CI, 1.60-68.61 vs aOR, 1.82; 95% CI, 0.38-8.77, respectively).

Conclusions: These results provide the first direct evidence that vitamin D sufficiency may be an important protective factor for food allergy in the first year of life.

Image
Fig 1. Prevalence of vitamin D insufficiency open bar, ≤50 nmol/L) and deficiency (solid bar, ≤25 nmol/L) among various food allergy phenotypes (A)
and food allergy with and without eczema among infants with both parents born in Australia (B).
Compared with infants with neither eczema nor food allergy, vitamin D insufficiency was significantly more common in infants with food allergy with or without eczema (P < .005 for both comparisons) but not in infants with eczema alone (P = .87).
Vitamin D insufficiency was also significantly more common among infants with 2 or more food allergies compared with infants with 1 food allergy (P = .045).


Image
Fig E2. Distribution of vitamin D levels in HealthNuts serum samples by parents’ country of birth (n = 708).


Wonder how many X more allergic to peanuts the immigrant children were (generally with dark skins) - the abstract does not say

Looks like those children with 10-20 ng were far more than 11X as allergic to peanuts than those with 0-20 ng

See also VitaminDWiki

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See also web

Attached files

ID Name Comment Uploaded Size Downloads
2173 Vit D percent.jpg admin 05 Mar, 2013 03:17 23.52 Kb 1148
2172 Peanut.jpg admin 05 Mar, 2013 03:11 14.13 Kb 1173
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