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10X more skin cancer cells killed by photodynamic therapy when add Vitamin D – Feb 2020

Vitamin D and Other Differentiation-Promoting Agents as Neoadjuvants for Photodynamic Therapy of Cancer

Photochem Photobiol, 2020 Feb 19, DOI: 10.1111/php.13230
Edward V Maytin 1 2, Tayyaba Hasan 2

VitaminDWiki

Finally getting around to using Vitamin D to enhance PDT in (non-US) humans

Notes:

  1. This study found that both topical and oral vitamin D greatly helped Photodynamic Therapy
  2. ALA-based PDT is routinely used in Europe, but not the US
  3. Founder of VItaminDWiki suspects that PDT will improve by another 10X when they try using pulsed PDT.

 Download the PDF from VitaminDWiki

The efficacy of photodynamic therapy (PDT) using aminolevulinic acid (ALA), which is preferentially taken up by cancerous cells and converted to protoporphyrin IX (PpIX), can be substantially improved by pretreating the tumor cells with Vitamin D (Vit D). Vit D is one of several "differentiation-promoting agents" that can promote the preferential accumulation of PpIX within the mitochondria of neoplastic cells, making them better targets for PDT. This article provides a historical overview of how the concept of using combination agents ("neoadjuvants") for PDT evolved, from initial discoveries about neoadjuvant effects of methotrexate and fluorouracil, to later studies to determine how Vitamin D and other agents actually work to augment PDT efficacy. While this review focuses mainly on skin cancer, it includes a discussion about how these concepts may be applied more broadly toward improving PDT outcomes in other types of cancer.


Created by admin. Last Modification: Saturday February 22, 2020 16:56:39 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
13520 Photodynamic Therapy of Cancer.pdf PDF 2020 admin 22 Feb, 2020 16:56 462.08 Kb 214
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