- Knee Osteoarthritis 1.7 more likely if low Vitamin D - Jan 2024
- Both Vitamin D and Magnesium appear to be needed if have Knee Osteoarthritis - Oct 2023
- Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022
- Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression - May 2023
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5 studies in both categories Osteoarthritis and Intervention - VitaminDWiki - Osteoarthritis category contains
- VitaminDWiki - Pain - chronic category contains
- 27+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title
- Study References (2022)
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Knee Osteoarthritis 1.7 more likely if low Vitamin D - Jan 2024
Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects
Technol Health Care. 2024 Jan 4. doi: 10.3233/THC-230802 PDF Price: EUR 27.50
Seçkin Özgür Tekeli 1, Özkan Köse 1 2, Dilek Yapar 3, Feyza Yağmur Tekeli 4, Mehmet Melih Asoğlu 1, Emre Mücahit Kartal 1Background: The extent of the association between vitamin D deficiency and knee osteoarthritis remains inadequately understood.
Objective: This study aimed to elucidate the relationship between vitamin D levels and knee osteoarthritis through a cross-sectional analysis.
Methods: This retrospective study involved an analysis of knee radiographs and serum 25-hydroxyvitamin D3 (25-(OH) vitamin D3) levels in a cohort of 3424 individuals (2901 women and 523 men). Knee osteoarthritis severity was evaluated using the Kellgren-Lawrence radiological scoring system.
Results: Of the participants, 49.2% (n= 1,683) were diagnosed with knee osteoarthritis. Among these patients, the levels of adjusted 25-(OH) vitamin D3 were significantly lower (p< 0.001). Regression analysis revealed a significant association between vitamin D deficiency and knee osteoarthritis, with an adjusted odds ratio (OR) of 1.7 (95% CI: 1.5-2.0; p< 0.001). Notably, a stronger association was observed between vitamin D deficiency and knee osteoarthritis in women under 65 compared to those aged 65 and above.
Conclusions: The findings of this study indicate a higher prevalence of vitamin D deficiency in patients with knee osteoarthritis. Maintaining adequate serum 25-(OH) vitamin D3 levels may prevent knee osteoarthritis, especially in women below 65.
Both Vitamin D and Magnesium appear to be needed if have Knee Osteoarthritis - Oct 2023
__Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis
Magnes Res. 2023 Jun 1;36(2):40-48. doi: 10.1684/mrh.2023.0515 PDF behind paywall
Ebru Yilmaz 1, Sena Ünver 2The maintenance of various physiological cellular processes requires mineral magnesium (Mg). The purpose of the study was to determine a possible association between Mg level and vitamin D levels, bone mineral density (BMD), chronic diseases, and radiographic stage in individuals with knee osteoarthritis (OA). The study included 98 individuals (62 female and 36 male) who had been diagnosed with at least grade 1 knee OA. Age, sex, smoking, body mass index (BMI), family history of osteoporosis, menopausal status, duration of menopause, the presence of chronic diseases (hypertension, diabetes mellitus, hyperlipidaemia, coronary artery disease, hypothyroidism) and radiological stage of knee OA were gathered from all patients. Also, serum calcium, Mg, alkaline phosphatase, parathyroid hormone (PTH) and 25(OH)-vitamin D levels were recorded. Additionally, dual-energy X-ray absorptiometry (DEXA) was used to measure the BMD of the lumbar vertebrae (L1-L4) and femoral neck as well as anteroposterior radiography of the knee in all patients. T scores ≤-2.5 were accepted as evidence of osteoporosis. The mean age of the study population was 59.15 ± 10.58 years.
The level of Mg significantly correlated with age, smoking, presence of chronic disease, duration of menopause, the level of vitamin D and PTH, and femoral neck T score (p<0.05). This study provides data supporting the relationship between magnesium levels and PTH and vitamin D levels, bone mineral density, and chronic disease. Future research is needed to examine the potential link between knee osteoarthritis and magnesium status.
Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis
Immunol Res . 2022 Dec 26. doi: 10.1007/s12026-022-09354-0
Ana Divjak 1 2, Ivan Jovanovic 3, Aleksandar Matic 4 5, Aleksandra Tomic Lucic 6 7, Nevena Gajovic 3, Milena Jurisevic 8, Aleksandra Jurisic Skevin 1 2, Mirjana Veselinovic 9 10This trial aimed to determine the possible therapeutic and immunomodulatory effects of vitamin D3 in patients with knee OA. In this open-label clinical trial, symptoms were assessed over 3 months in patients with primary knee OA receiving oral vitamin D3 4000 IU/day. Clinical response was evaluated at baseline and 3 months using WOMAC subscores and VAS. Serum levels of cytokines IL-1ß, TNF-a, IL-13, IL-17, IL-33, IL-4, and IL-10 were determined by ELISA method. Eighty patients with knee OA were included. All 80 completed the study; the median 25(OH)D3 level was 23.1 ng/ml at baseline and increased by 12.3 ng/ml after treatment. Vitamin D3 after 3 months of supplementation induced a significant reduction in VAS pain and WOMAC subscores. Using OMERACT-OARSI criteria, 86.7% of patients treated with vitamin D3 responded to treatment. At the end of 3 months, systemic values of IL-1ß (p < 0.01), IL-23 (p < 0.01), and IL-33 (p < 0.01) were significantly increased, values of TNF-a (p < 0.01), IL-13 (p < 0.01), and IL-17 (p < 0.01) were significantly decreased, while value of IL-4 was not significantly changed. No adverse events were detected. Treatment with vitamin D is associated with improvement in pain, as well as stiffness and physical function. Vitamin D supplementation increased systemic values of IL-33. Our results indicate that vitamin D3 supplementation may be used as a novel therapeutic in knee OA. Future studies are needed to investigate a potential role of IL-33 in the pathogenesis of knee OA.
Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression - May 2023
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VitaminDWiki -
5 studies in both categories Osteoarthritis and Intervention This list is automatically updated
- Knee osteoarthritis treated by Vitamin D - many studies
- Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
- Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
VitaminDWiki - Osteoarthritis category contains
59 items total - see also Overview Osteoporosis and vitamin D Overview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020
VitaminDWiki - Pain - chronic category contains
162 items in category Chronic pain See also
- Overview Pain and Vitamin D
- Percentage of people with pain increased 25 percent in 18 years – Jan 2019
- Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
82 items - "musculoskeletal pain" 490 items as of Aug 2023
- "chronic fatigue" 185 items as of Jan 2017
- Category Back Pain
42 items - 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
27+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title
This list is automatically updated
Items found: 27
Study References (2022)
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- Rainbow R, Ren W, Zeng L. Inflammation and joint tissue interactions in oa: implications for potential therapeutic approaches. Arthritis. 2012;2012:741582. https://doi.org/10.1155/2012/741582
- Wang Y, Teichtahl AJ, Pelletier JP, et al. Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the osteoarthritis Initiative. Rheumatology (Oxford). 2019;58(2):246–53. https://doi.org/10.1093/rheumatology/key274
- Wang K, Xu J, Hunter DJ, Ding C. Investigational drugs for the treatment of osteoarthritis. Expert Opin Invest Drugs. 2015;24:1539–56. https://doi.org/10.1517/13543784.2015.1091880
- Wang XB, Zhao FC, Yi LH, et al. MicroRNA-21-5p as a novel therapeutic target for osteoarthritis. Rheumatology (Oxford). 2019;58(8):1485–97. https://doi.org/10.1093/rheumatology/kez102
- Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review. Rheumatology (Oxford). 2013;52(7):1323–34. https://doi.org/10.1093/rheumatology/ket132
- Aranow C. Vitamin D and the immune system. J Investig Med. 2011;59(6):881–6. https://doi.org/10.2310/JIM.0b013e31821b8755
- Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33–42. https://doi.org/10.1038/nrrheum.2010.196
- Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014;2014:561459. https://doi.org/10.1155/2014/561459
- Rai V, Radwan MM, Agrawal DK. IL-33, IL-37, and vitamin D interaction mediate immunomodulation of inflammation in degenerating cartilage. Antibodies. 2021;10(4):41. https://doi.org/10.3390/antib10040041
- Pavlovic S, Zdravkovic N, Radosavljevic G, et al. Interleukin-33/ST2: a new signaling pathway in immunity and immunopathology. Vojnosanit Pregl. 2012;69(1):69–77. https://doi.org/10.2298/vsp1201069p
- Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018;28:8–27. https://doi.org/10.1111/imr.12621
- Shipton EA, Shipton EE. Vitamin D and pain: vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat. 2015;2015:904–67. https://doi.org/10.1155/2015/904967
- Alkan G, Akgol G. Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis? J Back Musculoskelet Rehabil. 2017;30(4):897–901. https://doi.org/10.3233/BMR-160589
- Zhang FF, Driban JB, Lo GH, et al. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014;144(12):2002–8. https://doi.org/10.3945/jn.114.193227
- Glover TL, Horgas AL, Fillinbim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5:447–53. https://doi.org/10.2217/pmt.15.43
- Stannus OP, Jones G, Blizzard L, Cicuttini FM, Ding C. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann Rheum Dis. 2013;72(4):535–40. https://doi.org/10.1136/annrheumdis-2011-201047
- Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis. 1957;16(4):494–502. https://doi.org/10.1136/ard.16.4.494
- Bellamy N, Bell MJ, Goldsmith CH, et al. Evaluation of WOMAC 20, 50, 70 response criteria in patients treated with hylan G-F 20 for knee osteoarthritis. Ann Rheum Dis. 2005;64:881–5. https://doi.org/10.1136/ard.2004.026443
- Pham T, Van Der Heijde D, Altman RD, et al. OMERACT-OARSI initiative: osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthr Cartil. 2004;12:389–99. https://doi.org/10.1016/j.joca.2004.02.001
- Jovanovic M, et al. Metabolic syndrome attenuates ulcerative colitis: correlation with interleukin-10 and galectin-3 expression. World J Gastroenterol. 2019;25:6465–82. https://doi.org/10.3748/wjg.v25.i43.6465
- Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of vitamin D supplementation on pain: a systematic review and meta-analysis. Pain Physician. 2016;19:415–27.
- Hussain S, Singh A, Akhtar M, et al. Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017;37:1489–98. https://doi.org/10.1007/s00296-017-3719-0
- Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471:3556–62. https://doi.org/10.1007/s11999-013-3201-6
- Jin X, Jones G, Cicuttini F, et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 2016;315(10):1005–13. https://doi.org/10.1001/jama.2016.1961
- Arden NK, Cro S, Sheard S, et al. The effect of vitamin D supplementation on knee osteoarthritis, the video study: a randomised controlled trial. Osteoarthr Cartil. 2016;24:1858–66. https://doi.org/10.1016/j.joca.2016.05.020
- Mc Alindon T, Lavalley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis. JAMA. 2013;309:155–62. https://doi.org/10.1001/jama.2012.164487
- Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14–20. https://doi.org/10.1016/j.ijsu.2017.08.010
- Diao N, Yang B, Yu F. Effect of vitamin D supplementation on knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Clin Biochem. 2017;50:1312–6. https://doi.org/10.1016/j.clinbiochem.2017.09.001
- Zhao ZX, He Y, Peng LH, et al. Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(9):2393–403. https://doi.org/10.1007/s40520-020-01778-8
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- Glover TL, Horgas AL, Fillingim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5(6):447–53. https://doi.org/10.2217/pmt.15.43
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