- Pollution reduces the amount of time that people are outdoors
- Pollution attenuates the amount of UVB getting to the skin (by only a few percent)
- Pollution is often associated with hot temperatures, another reason to not go outdoors
- Irritation/Inflammation of lungs may consume vitamin D
- Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Air pollution associated with poor bone density (less vitamin D) – Nov 2017
- Vitamin D level: 27 ng if low pollution, 12 ng if high pollution (Delhi children) – June 2018
- Air Pollution 2000-2012 nice interactive maps
- Fewer pre-term births after pollution reduction (vitamin D not mentioned) April 2014
- Household chemicals found to be the source of half of urban pollution (and thus decreased urban vitamin D) – Feb 2018
- Air pollution reduces UV and thus vitamin D - Aug 2010
- Air pollution during pregnancy reduced vitamin D levels by only 0.4 ng– Aug 2012
- Higher air pollution associated with 7 ng lower vitamin D levels – Aug 2013
- Blacks living in urban area vs rural have less vitamin D if older than 50 – Oct 2011
- Even small amounts of UVB result in increased vitamin D levels – March 2012 by MacKenzie
- Search VitaminDWiki for MacKenzie and UV 50 items as of Oct 2016
-  Effects of urban pollution on UV spectral irradiances: MacKenzie 2008
Decrease in UVB: ratio of polluted sky in Tokyo vs clear sky in New Zealand
Note: Tokyo is much closer to equator, so should have much more UVB than NZ
Note: You can ignore the blue = winter line
Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter
PLoS One. 2018 Aug 29;13(8):e0200040. doi: 10.1371/journal.pone.0200040. eCollection 2018.
Pfeffer PE1,2, Lu H1, Mann EH1, Chen YH1, Ho TR1, Cousins DJ1,3, Corrigan C1, Kelly FJ4, Mudway IS4, Hawrylowicz CM1.
BACKGROUND: Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma.
OBJECTIVES: Mechanistic cell culture experiments were undertaken to ascertain whether vitamin D abrogates PM-induced inflammatory responses of human bronchial epithelial cells (HBECs) through enhancement of antioxidant pathways.
METHODS: Transcriptome analysis, PCR and ELISA were undertaken to delineate markers of inflammation and oxidative stress; with comparison of expression in primary HBECs from healthy and asthmatic donors cultured with reference urban PM in the presence/absence of vitamin D.
Transcriptome analysis identified over 500 genes significantly perturbed by PM-stimulation, including multiple pro-inflammatory cytokines. Vitamin D altered expression of a subset of these PM-induced genes, including suppressing IL6. Addition of vitamin D suppressed PM-stimulated IL-6 production, although to significantly greater extent in healthy versus asthmatic donor cultures. Vitamin D also differentially affected PM-stimulated GM-CSF, with suppression in healthy HBECs and enhancement in asthmatic cultures. Vitamin D increased HBEC expression of the antioxidant pathway gene G6PD, increased the ratio of reduced to oxidised glutathione, and in PM-stimulated cultures decreased the formation of 8-isoprostane. Pre-treatment with vitamin D decreased CXCL8 and further decreased IL-6 production in PM-stimulated cultures, an effect abrogated by inhibition of G6PD with DHEA, supporting a role for this pathway in the anti-inflammatory actions of vitamin D.
In a study using HBECs from 18 donors, vitamin D enhanced HBEC antioxidant responses and modulated the immune response to PM, suggesting that vitamin D may protect the airways from pathological pollution-induced inflammation.
By the founder of VitaminDWiki, who lives near Seattle
In Aug of 2018 there was a lot of particulate matter in the air
The air pollution from wildfires has recently been called a smokestorm (by Cliff Mass)
I went for a bike ride when the smokestorm was almost gone
Felt a restriction in my breathing that night and the next morning.,
I inhaled 3 puffs of Vitamin D and the restriction totally went away in less than an hour
I do not know if the Vitamin D treated the health problem or it the problem would have gone away without it.
- Independent association between air pollutants and vitamin D deficiency in young children in Isfahan, Iran Aug 2013 free full text online
- Temporal variation in air pollution concentrations and preterm birth-a population based epidemiological study Sweden, Jan 2012 free full text online
Ozone during the first trimester associated with pre-term birth, unless it occured in the fall when vitamin D levels were highest
- The effects of air pollution on vitamin D status in healthy women: A cross sectional study BMC Health 2010, Iran, free full text online
Many reasons for low vitamin D in Iran (India, etc): Hot (so stay indoors in air conditioning), Dark skin, want lighter skin, lots of clothing, air pollution
- Independent association between air pollutants and vitamin D deficiency in young children in Isfahan, Iran 2014
Publisher wants $54 for the PDF
- California Sees 76% Decline in Cancer Risk Thanks to Cleaner Air
Scientific American, Sept 2015, no mention of Vitamin D
Vitamin D increases when people can get sunshine when they no longer have to avoid pollution
- Alzheimer’s disease: Condition linked to exposure to air pollution and lack of Vitamin D
Oct 2016 - not sure if Vitamin D is the link between air pollution and Alzheimer’s disease
- Low serum vitamin D-status, air pollution and obesity: A dangerous liaison Sept 2016
Download the PDF from VitaminDWiki
- Vitamin D reduces some of the pollution problems in human cell culture (not in bodies so far) - May 2017
Vitamin D Counteracts an IL-23-dependent IL-17A+IFNγ+ Response Driven by Urban Particulate Matter
https://doi.org/10.1165/rcmb.2016-0409OC Publisher wants $25 for the PDF
- Air Pollution Tied to Kidney Disease NY Times Sept 2017
Areas with high pollution have 27% more Chronic Kidney Disease - No mention of Vitamin D
Free PDF is online