Vitamin D increases Prostaglandins which increases a wide variety of pains – 2018

See also VitaminDWiki

Pain - chronic category in VitaminDWiki

Starts with the following

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Prostaglandins: Definition, Function, and Associated Conditions Self-Hacked Jan 2018

(Nothing about Vitamin D)

Negative Effects of High Prostaglandin Levels

Prostaglandins (PGD2) Can Increase Allergies

High PGE2 Levels May Decrease the Ability to Fight Cancer

High Prostaglandins May Contribute To Inflammation-Related Pain

High Prostaglandins May Cause Migraines and Headaches

High Prostaglandin Levels Cause Menstrual Cramps

High PGE2 Levels May Play a Part in Osteogenesis Imperfecta

High PGE2 Levels Are Linked to Celiac Disease

High PGE2 Levels are Linked to ALS

High PGE2 Levels May Play a Role in Reflux Esophagitis

High PGE2 Levels May Play a Role in Deformity of Nails and Fingers

High PGD2 Levels May Play a Role in Male Pattern Baldness

High PGE2 Levels are Linked to Depression

High PGE2 Levels are Linked to Alzheimer’s Disease

High PGD2 Levels are Linked to Kidney Failure

High PGE2 Levels are Linked to Schizophrenia

Health Benefits of High Prostaglandin Levels

Prostaglandins Protect the Gut and Help Against Ulcers

Prostaglandins Protect the Heart

Prostaglandins Induce Labor

Prostaglandins (PGE2) Can Calm Allergies

PGE2 and PGF2α May Improve Sperm Function

Low Vitamin D increases Prostaglandins – 2015

Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities

Pain Research and Treatment, Vol 2015, Article ID 904967, 12 pages, http://dx.doi.org/10.1155/2015/904967

Edward A. Shipton and Elspeth E. Shipton

Department of Anaesthesia, University of Otago, Christchurch, Corner of Riccarton and Hagley Avenues, Christchurch 8042, New Zealand

📄 Download the PDF from VitaminDWiki

The emergence of new data suggests that the benefits of Vitamin D extend beyond healthy bones. This paper looks at Vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. The interfaces between pain and Vitamin D and the mechanisms of action of Vitamin D on pain processes are explored. Finally the association between Vitamin D and pain comorbidities such as sleep and depression is investigated. The paper shows that Vitamin D exerts anatomic, hormonal, neurological, and immunological influences on pain manifestation, thereby playing a role in the aetiology and maintenance of chronic pain states and associated comorbidities. More research is necessary to determine whether Vitamin D is useful in the treatment of various pain conditions and whether or not the effect is limited to patients who are deficient in Vitamin D.

Clipped from PDF

4.3.3. Vitamin D and Prostaglandins

Vitamin D influences prostaglandin action by inhibiting COX-2 expression and by stimulating 15-prostaglandin dehydrogenase (15-PGDH) expression [102]. The enzyme 15-PGDH degrades prostaglandins and inhibits prostaglandin-E2 receptor (PGE2) subtypes and prostaglandin-F2 alpha receptor subtypes (Box 2) [102]. Prostaglandins have a direct effect on sensory neurones by lowering the firing threshold, increasing the number of action potentials elicited by a depolarizing stimulus, and enhancing SP and CGRP release [103]. Prostaglandins mediate neuropathic pain in the spinal cord via PGE2 depolarising wide dynamic range neurones [27].

2,000 IU of vitamin D reduced the prostaglandin cascade in Breast Cancer - 2013

Vitamin D favorably alters the cancer promoting prostaglandin cascade

Anticancer Res. 2013 Sep;33(9):3861-6.

Qin W1, Smith C, Jensen M, Holick MF, Sauter ER.

1 11937 U.S. Hwy 271, Tyler, TX, U.S.A. edward.sauter@uthct.edu.

BACKGROUND:

Preclinical studies suggest that 1,25-dihydroxyvitamin D [1,25(OH)2D] and celecoxib inhibit prostaglandins (PGs) associated with cancer through different mechanisms. We determined if there was synergy in their use.

PATIENTS AND METHODS:

A total of 36 healthy women received daily for one month/menstrual cycle: placebo, 400 international units (IU) vitamin D-3, 2,000 IU vitamin D-3, or 2,000 IU vitamin D-3 plus 400 mg celecoxib. Serum and nipple aspirate fluid (NAF) were analyzed for PGE2 and transforming growth factor (TGF)β1 and -2; serum for 25(OH)D (total, -D-2, -D-3), plasma for celecoxib; and mammary duct RNA for cyclooxygenase (COX)2.

RESULTS:

25(OH)D-3 increased (p<0.01) only in the groups receiving 2,000 IU vitamin D-3. PGE2 decreased in the breast (p=0.01) only after receiving 2,000 IU vitamin D-3; 2,000 IU vitamin D-3 alone was more effective in decreasing PGE2 than 2,000 IU vitamin D-3 plus celecoxib (p=0.018). COX2 expression decreased only in the breasts of women taking 2,000 IU vitamin D-3. Change in circulating 25(OH)D-3 correlated with change in TGFβ2 in the breast.

CONCLUSION: Vitamin D-3 reduces the PG cascade and increases TGFβ2 in a dose-dependent fashion. Adding celecoxib did not provide synergy.

PMID: 24023320

Created April 2018