Loading...
 
Toggle Health Problems and D

Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022

The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis - Dec 2022

Immunol Res . 2022 Dec 26. doi: 10.1007/s12026-022-09354-0
Ana Divjak 1 2, Ivan Jovanovic 3, Aleksandar Matic 4 5, Aleksandra Tomic Lucic 6 7, Nevena Gajovic 3, Milena Jurisevic 8, Aleksandra Jurisic Skevin 1 2, Mirjana Veselinovic 9 10

This trial aimed to determine the possible therapeutic and immunomodulatory effects of vitamin D3 in patients with knee OA. In this open-label clinical trial, symptoms were assessed over 3 months in patients with primary knee OA receiving oral vitamin D3 4000 IU/day. Clinical response was evaluated at baseline and 3 months using WOMAC subscores and VAS. Serum levels of cytokines IL-1ß, TNF-a, IL-13, IL-17, IL-33, IL-4, and IL-10 were determined by ELISA method. Eighty patients with knee OA were included. All 80 completed the study; the median 25(OH)D3 level was 23.1 ng/ml at baseline and increased by 12.3 ng/ml after treatment. Vitamin D3 after 3 months of supplementation induced a significant reduction in VAS pain and WOMAC subscores. Using OMERACT-OARSI criteria, 86.7% of patients treated with vitamin D3 responded to treatment. At the end of 3 months, systemic values of IL-1ß (p < 0.01), IL-23 (p < 0.01), and IL-33 (p < 0.01) were significantly increased, values of TNF-a (p < 0.01), IL-13 (p < 0.01), and IL-17 (p < 0.01) were significantly decreased, while value of IL-4 was not significantly changed. No adverse events were detected. Treatment with vitamin D is associated with improvement in pain, as well as stiffness and physical function. Vitamin D supplementation increased systemic values of IL-33. Our results indicate that vitamin D3 supplementation may be used as a novel therapeutic in knee OA. Future studies are needed to investigate a potential role of IL-33 in the pathogenesis of knee OA.

Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression - May 2023

 Download the PDF from VitaminDWiki

VitaminDWiki - 4 studies in both categories Osteoarthritis and Intervention

This list is automatically updated

VitaminDWiki - Osteoarthritis category contains

57 items total - see also Overview Osteoporosis and vitamin D

Overview Osteoarthritis and Vitamin D
Search VitaminDWiki for CARTILAGE 393 items as of July 2018
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020

Click here for 2014 study

VitaminDWiki - Pain - chronic category contains

150 items in category Chronic pain

See also

26+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title

This list is automatically updated

Items found: 26
Title Modified
Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022 26 Dec, 2022
I needed more than Vitamin D to treat my knee osteoarthritis 06 Nov, 2021
Knee osteoarthritis helped by Low Level Laser Therapy 02 Nov, 2020
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 21 Oct, 2020
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 10 Oct, 2018
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 10 Jul, 2018
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 29 Jul, 2017
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 29 Jul, 2017
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 29 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 25 Apr, 2017
Knee osteoarthritis strongly associated with low Boron – 2015 24 Mar, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 21 Dec, 2016
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 06 Oct, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 03 Oct, 2015
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT 08 Aug, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 12 Apr, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 07 Oct, 2014
Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012 11 May, 2014
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012
Knee Osteoarthritis pain cut in half by eating sesame seed powder for 2 months - Oct 2019 No value for &#039;modification_date_major&#039;
Study References
  1. Orlowsky EW, Kraus VB. The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol. 2015;42(3):363–71. https://doi.org/10.3899/jrheum.140382
  2. Rainbow R, Ren W, Zeng L. Inflammation and joint tissue interactions in oa: implications for potential therapeutic approaches. Arthritis. 2012;2012:741582. https://doi.org/10.1155/2012/741582
  3. Wang Y, Teichtahl AJ, Pelletier JP, et al. Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the osteoarthritis Initiative. Rheumatology (Oxford). 2019;58(2):246–53. https://doi.org/10.1093/rheumatology/key274
  4. Wang K, Xu J, Hunter DJ, Ding C. Investigational drugs for the treatment of osteoarthritis. Expert Opin Invest Drugs. 2015;24:1539–56. https://doi.org/10.1517/13543784.2015.1091880
  5. Wang XB, Zhao FC, Yi LH, et al. MicroRNA-21-5p as a novel therapeutic target for osteoarthritis. Rheumatology (Oxford). 2019;58(8):1485–97. https://doi.org/10.1093/rheumatology/kez102
  6. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review. Rheumatology (Oxford). 2013;52(7):1323–34. https://doi.org/10.1093/rheumatology/ket132
  7. Aranow C. Vitamin D and the immune system. J Investig Med. 2011;59(6):881–6. https://doi.org/10.2310/JIM.0b013e31821b8755
  8. Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33–42. https://doi.org/10.1038/nrrheum.2010.196
  9. Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014;2014:561459. https://doi.org/10.1155/2014/561459
  10. Rai V, Radwan MM, Agrawal DK. IL-33, IL-37, and vitamin D interaction mediate immunomodulation of inflammation in degenerating cartilage. Antibodies. 2021;10(4):41. https://doi.org/10.3390/antib10040041
  11. Pavlovic S, Zdravkovic N, Radosavljevic G, et al. Interleukin-33/ST2: a new signaling pathway in immunity and immunopathology. Vojnosanit Pregl. 2012;69(1):69–77. https://doi.org/10.2298/vsp1201069p
  12. Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018;28:8–27. https://doi.org/10.1111/imr.12621
  13. Shipton EA, Shipton EE. Vitamin D and pain: vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat. 2015;2015:904–67. https://doi.org/10.1155/2015/904967
  14. Alkan G, Akgol G. Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis? J Back Musculoskelet Rehabil. 2017;30(4):897–901. https://doi.org/10.3233/BMR-160589
  15. Zhang FF, Driban JB, Lo GH, et al. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014;144(12):2002–8. https://doi.org/10.3945/jn.114.193227
  16. Glover TL, Horgas AL, Fillinbim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5:447–53. https://doi.org/10.2217/pmt.15.43
  17. Stannus OP, Jones G, Blizzard L, Cicuttini FM, Ding C. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann Rheum Dis. 2013;72(4):535–40. https://doi.org/10.1136/annrheumdis-2011-201047
  18. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis. 1957;16(4):494–502. https://doi.org/10.1136/ard.16.4.494
  19. Bellamy N, Bell MJ, Goldsmith CH, et al. Evaluation of WOMAC 20, 50, 70 response criteria in patients treated with hylan G-F 20 for knee osteoarthritis. Ann Rheum Dis. 2005;64:881–5. https://doi.org/10.1136/ard.2004.026443
  20. Pham T, Van Der Heijde D, Altman RD, et al. OMERACT-OARSI initiative: osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthr Cartil. 2004;12:389–99. https://doi.org/10.1016/j.joca.2004.02.001
  21. Jovanovic M, et al. Metabolic syndrome attenuates ulcerative colitis: correlation with interleukin-10 and galectin-3 expression. World J Gastroenterol. 2019;25:6465–82. https://doi.org/10.3748/wjg.v25.i43.6465
  22. Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of vitamin D supplementation on pain: a systematic review and meta-analysis. Pain Physician. 2016;19:415–27.
  23. Hussain S, Singh A, Akhtar M, et al. Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017;37:1489–98. https://doi.org/10.1007/s00296-017-3719-0
  24. Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471:3556–62. https://doi.org/10.1007/s11999-013-3201-6
  25. Jin X, Jones G, Cicuttini F, et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 2016;315(10):1005–13. https://doi.org/10.1001/jama.2016.1961
  26. Arden NK, Cro S, Sheard S, et al. The effect of vitamin D supplementation on knee osteoarthritis, the video study: a randomised controlled trial. Osteoarthr Cartil. 2016;24:1858–66. https://doi.org/10.1016/j.joca.2016.05.020
  27. Mc Alindon T, Lavalley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis. JAMA. 2013;309:155–62. https://doi.org/10.1001/jama.2012.164487
  28. Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14–20. https://doi.org/10.1016/j.ijsu.2017.08.010
  29. Diao N, Yang B, Yu F. Effect of vitamin D supplementation on knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Clin Biochem. 2017;50:1312–6. https://doi.org/10.1016/j.clinbiochem.2017.09.001
  30. Zhao ZX, He Y, Peng LH, et al. Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(9):2393–403. https://doi.org/10.1007/s40520-020-01778-8
  31. Tateiwa D, Yoshikawa H, Kaito T. Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review. Cells. 2019;8(8):818. https://doi.org/10.3390/cells8080818
  32. Glover TL, Horgas AL, Fillingim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5(6):447–53. https://doi.org/10.2217/pmt.15.43
  33. Martens P, Gysemans C, Verstuyf A, Mathieu C. Vitamin D’s effect on immune function. Nutrients. 2020;12:1248. https://doi.org/10.3390/nu12051248
  34. Milosavljevic MZ, Jovanovic IP, Pejnovic NN, et al. Deletion of IL-33R attenuates VEGF expression and enhances necrosis in mammary carcinoma. Oncotarget. 2016;7(14):18106–15.
  35. Griesenauer B, Paczesny S. ST2/IL-33 axis in immune cells during inflammatory diseases. Front Immunol. 2017;8:475. https://doi.org/10.3389/fimmu.2017.00475
  36. Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B. IL-33- activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol. 2011;41(6):1675–86. https://doi.org/10.1002/eji.201041033
  37. Jovanovic I, Pejnovic N, Radosavljevic G, Arsenijevic N, Lukic ML. IL-33/ST2 axis in innate and acquired immunity to tumors. OncoImmunology. 2012;1(2):229–31. https://doi.org/10.4161/onci.1.2.18131
  38. Jovanovic I, Radosavljevic G, Mitrovic M, et al. ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma. Eur J Immunol. 2011;41(7):1902–12. https://doi.org/10.1002/eji.201141417
  39. Jovanovic I, Pejnovic N, Radosavljevic G, et al. Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoural accumulation of immunosuppressive and innate lymphoid cells. Int J Cancer. 2014;134(7):1669–16682. https://doi.org/10.1002/ijc.28481
  40. He Z, Song Y, Yi Y, et al. Blockade of IL-33 signalling attenuates osteoarthritis. Clin Transl Immunol. 2020;9(10):e1185. https://doi.org/10.1002/cti2.1187
  41. De Martinis M, Ginaldi L, Sirufo MM, et al. IL-33/vitamin D crosstalk in psoriasis-associated osteoporosis. Front Immunol. 2021;11:604055. https://doi.org/10.3389/fimmu.2020.604055
  42. Sirufo MM, Ginaldi L, Martinis DE, M,. The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis. Rheumatology (Oxford). 2021;60(8):e300. https://doi.org/10.1093/rheumatology/keab292
  43. Annalora AJ, Jozic M, Marcus CB, Iversen PL. Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand in dependent functions. Toxicol Appl Pharmacol. 2019;364:55–67. https://doi.org/10.1016/j.taap.2018.12.009
Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022        
4919 visitors, last modified 01 May, 2023,
Printer Friendly Follow this page for updates
Pain - chronic 142 Intervention 764 Osteoarthritis 55
Page actions
Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
19530 matrix metalloprotease_CompressPdf.pdf PDF 2023 admin 01 May, 2023 14:52 684.58 Kb 12