Table of contents
- 13 VitaminDWiki pages with HERPES or SHINGLES in title (March 2023)
- 2.7 X more likely to have low Vitamin D if have Herpes Simplex Virus-2 - Nov 2022
- Herpesvirus and Vitamin D in immunosuppressed patients - inconclusive meta-analysis Jan 2021
- Cold Sores (herpes labialis) occures more often in winter, is associated with low levels of vitamin D - 2019
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The association between serum 25-hydroxyvitamin D and the prevalence of herpes simplex virus
J Med Virol . 2022 Nov 11. doi: 10.1002/jmv.2829
Jiaofeng Huang 1 2 , Yinlian Wu 1 2 , Mingfang Wang 1 2 , Su Lin 1 2
Objective: Previous studies have reported a potential anti-infection effect for vitamin D. However, the relationship between vitamin D status and herpes simplex virus (HSV) infection has not yet been evaluated. Therefore, this study aimed to determine the association between serum 25-hydroxyvitamin D [25(OH)D] and infection with HSV types 1 and 2 (HSV-1 and HSV-2).
Methods: Data were collected from the National Health and Nutrition Examination Survey (NHANES) from 2007-2016. The association between 25(OH)D and HSV prevalence was evaluated using propensity score matching (PSM) and univariate and multivariate logistic regression analyses.
Results: Overall, 14174 participants were included in the final analysis. Before PSM, 8639 (60.9%) had positive HSV-1 and 2636 (18.6%) had HSV-2. The HSV-1 and HSV-2 positive groups had more females and older individuals (P<0.05).
The HSV-2 patients had lower 25(OH)D levels than those with HSV-1. Age and gender did not differ in the groups after PSM (P>0.05).
The 25(OH)D level was significantly lower in the HSV-1 and HSV-2 groups than in the non-HSV infection groups. Multivariate logistic regression showed that serum 25(OH)D level was negatively associated with HSV-1 and HSV-2 infection (OR=0.730 and 0.691, P<0.001, respectively).
Vitamin D deficiency was an independent risk factor for both HSV-1 and HSV-2 (adjusted OR=2.205 and 2.704, P<0.001, respectively).
Conclusion: Lower serum 25(OH)D levels correlated significantly with increased HSV-1 and HSV-2 infection risk This article is protected by copyright. All rights reserved.
__Vitamin D Deficiency or Supplementation and the Risk of Human Herpesvirus Infections or Reactivation: A Systematic Review and Meta-analysis++
Open Forum Infectious Diseases, Volume 8, Issue 1, January 2021, ofaa570, https://doi.org/10.1093/ofid/ofaa570Liang-Yu Lin, Ketaki Bhate, Harriet Forbes, Liam Smeeth, Charlotte Warren-Gash, Sinéad M Langan
Vitamin D may protect against respiratory virus infections, but any association with herpesviruses is unclear.
We undertook a systematic review of vitamin D deficiency or supplementation and the risk of 8 human herpesviruses. Six databases and 4 gray literature databases were searched for relevant cohort studies, case–control studies, and clinical trials.
Ten studies were included, all conducted among immunosuppressed patients. There was no evidence that vitamin D deficiency is associated with cytomegalovirus (CMV) disease (pooled risk ratio, 1.06; 95% CI, 0.66–1.7), herpes zoster after transplantation (1 study), or HHV-8 among HIV patients (1 study). Vitamin D supplementation may decrease herpes zoster among hemodialysis patients (1 study) or CMV disease after renal transplantation (1 study), but supplementation was not associated with reduced EBV viral load among multiple sclerosis patients (1 study).
Any association between vitamin D and herpesviruses remains inconclusive. Further studies in the general population are needed.
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Cold Sores (herpes labialis) occures more often in winter, is associated with low levels of vitamin D - 2019
Vitamin D Levels in Patients with Recurrent Herpes Labialis
Viral Immunol . 2019 Jul/Aug;32(6):258-262. doi: 10.1089/vim.2019.0013
Aynure Öztekin 1, Coşkun Öztekin 2
Recurrent infections of herpes simplex virus in the orolabial area are known as recurrent herpes labialis (RHL). Vitamin D has been shown to have an important immunomodulatory role and to be associated with several infectious diseases. This hospital-based case-control study aimed at investigating the association between vitamin D and RHL by comparing vitamin D levels in individuals with and without RHL. Individuals who presented to the dermatology clinic at a state hospital due to RHL (n = 50) and matching control group of healthy volunteers (n = 51) were studied. Their vitamin D levels were measured, stratified based on clinical guidelines, and compared. The average serum vitamin D (25-hydroxyvitamin D) levels were 23.8 ± 15.5 and 42.0 ± 26.3 nM in the patient and control groups, with significant differences between their average serum vitamin D levels and vitamin D status. The studied population had serious vitamin D deficiency regardless of having RHL, with vitamin D levels below the adequate limits in more than 96% of the population. Most importantly, the study established a significant association between low serum vitamin D levels and the presence of RHL. Further interventional and pathophysiological studies should clarify the nature and mechanism of the relationship.
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