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Yet another low Vitamin D health problem with increased COVID-19 risks (Vertebral Fracture) – Oct 2020

Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes

The Journal of Clinical Endocrinology & Metabolism, 2020, Vol. XX, No. XX, 1-13
Luigi di Filippo,1 Anna Maria Formenti,1 Mauro Doga,1 Erika Pedone,1 Patrizia Rovere-Querini,2 and Andrea Giustina1 ORCiD number: 0000-0001-6783-3398

  • 1Institute of Endocrine and Metabolic Sciences, Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan 20132, Italy; and
  • 2Vita-Salute San Raffaele University and Division of Transplantation, Immunology and Transplantation Diseases, San Raffaele Scientific Institute, Milan 20132, Italy

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Some other health problems associated with both low Vitamin D and increased COVID-19
Items in both categories Diabetes and Virus



Old age
Indoors more
4X reduced conversion of light into Vitamin D,
Less aborption of Vitamin D from food
Shift Workers

Poor Sleep

Breathing Problems

Gut Problems

Items in both categories Hypertension and Virus

Low D ==> Higher COVID-19 Risk

26 health factors increase the risk of COVID-19 – all are associated with low vitamin D

26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
Text list (click on above link to get details)

  • Cancer
  • Chronic kidney disease
  • COPD (chronic obstructive pulmonary disease)
  • Heart conditions, such as heart failure, coronary artery disease, or cardiomyopathies
  • Immunocompromised state (weakened immune system) from solid organ transplant
  • Obesity (body mass index (BMI) of 30 kg/m2 or higher but < 40 kg/m2)
  • Severe Obesity (BMI ≥ 40 kg/m2)
  • Pregnancy
  • Sickle cell disease
  • Smoking
  • Type 2 diabetes mellitus

 Download the PDF from VitaminDWiki

Context and Objective: COVID-19 has become the most relevant medical issue globally. Despite several studies that have investigated clinical characteristics of COVID-19 patients, no data have been reported on the prevalence of vertebral fractures (VFs). Since VFs may influence cardiorespiratory function and disease outcomes, the aim of this study was to assess VFs prevalence and clinical impact in COVID-19.

Design and Patients: This was a retrospective cohort study performed at San Raffaele Hospital, a tertiary health care hospital in Italy. We included COVID-19 patients for whom lateral chest x-rays at emergency department were available. VFs were detected using a semiquantitative evaluation of vertebral shape on chest x-rays.

Results: A total of 114 patients were included in this study and thoracic VFs were detected in 41 patients (36%). Patients with VFs were older and more frequently affected by hypertension and coronary artery disease (P < 0.001, P = 0.007, P = 0.034; respectively). Thirty-six (88%) patients in VFs+ group compared to 54 (74%) in VFs- group were hospitalized (P = 0.08). Patients with VFs more frequently required noninvasive mechanical ventilation compared with those without VFs (P = 0.02). Mortality was 22% in VFs+ group and 10% in VFs- group (P = 0.07). In particular, mortality was higher in patients with severe VFs compared with those with moderate and mild VFs (P = 0.04).

Conclusions: VFs may integrate the cardiorespiratory risk of COVID-19 patients, being a useful and easy to measure clinical marker of fragility and poor prognosis. We suggest that morphometric thoracic vertebral evaluation should be performed in all suspected COVID-19 patients undergoing chest x-rays.

Created by admin. Last Modification: Saturday February 20, 2021 20:02:04 GMT-0000 by admin. (Version 12)

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