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Wheezing and asthmatic children have weaker Vitamin D responses - May 2022


Vitamin D replacement in children with acute wheeze: a dose-escalation study

ERJ Open Research 2022 8: 00609-2021; DOI: 10.1183/23120541.00609-2021
Christos Stefanidis, Andrew Bush, Christopher Newby, Chinedu Nwokoro, Susan Liebeschuetz, Imogen P. Skene, Christopher J. Griffiths, Adrian R. Martineau

Vitamin D supplementation at the current UK recommended level (400 IU·day−1) or enhanced supplementation (1000 IU·day−1) failed to achieve adequate levels of vitamin D (>75 nmol·L−1) in vitamin-D-insufficient children with acute wheeze https://bit.ly/3J43Ouo

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To the Editor:

Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3], but data relating to effects of vitamin D on risk of preschool wheeze and asthma attacks in childhood are more limited [4]. In preparation for a randomised controlled trial (RCT) of vitamin D in children with recurrent preschool wheeze or school-age asthma, we carried out a dose-escalation study to find the daily vitamin D3 supplementation regimen that is most effective in elevating circulating 25-hydroxyvitamin D (25(OH)D) concentrations in these children. We hypothesised that daily oral vitamin D3 supplementation of 1000 IU would be more effective than 400 IU (UK recommendation [5]) in elevating the circulating 25(OH)D concentration to ≥75 nmol·L−1 at 3 months in vitamin-D-insufficient children with recurrent preschool wheeze or school-age asthma.

Children were recruited from primary and secondary care if they were aged 1–4 years with ≥2 self-reported episodes of acute wheeze requiring unscheduled healthcare attendances in the preceding year (preschool children), or aged 5–12 years with doctor-diagnosed asthma and ≥1 self-reported asthma attack requiring an unscheduled healthcare attendance in the preceding year (school children). Exclusion criteria were baseline 25(OH)D level ≥75 nmol·L−1, concurrent vitamin D supplementation, or a history of other chronic or acute respiratory or systemic conditions.
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15+ VitaminDWiki pages have WHEEZING in the title

This list is automatically updated

Items found: 15
Title Modified
Vitamin D levels are low during Recurrent Wheezing - Feb 2024 24 Feb, 2024
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
Recurrent Wheezing in children is associated with low Vitamin D – several studies 04 Sep, 2022
Wheezing and asthmatic children have weaker Vitamin D responses - May 2022 19 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Viral infection wheezing 24X more likely if less than 15 ng of Vitamin D – Dec 2019 04 Apr, 2020
Gene which predicts wheezing is associated with low vitamin D – Oct 2019 18 Oct, 2019
Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018 06 Dec, 2018
Recurrent wheeze 2X more likely if endotoxin (on some bacteria) and low vitamin D – May 2016 15 Dec, 2017
Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015 10 May, 2016
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015 25 Aug, 2015
Children who wheezed were 2.7X more likely to have little vitamin D – April 2014 18 Apr, 2015
Vitamin D and wheeze – especially in seniors – Aug 2011 26 Apr, 2014
Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013 30 Jun, 2013

Study should have increased the dose size with increased weight or age

1000 IU per 25 lbs.jpg
Example: 1000 IU at 25 lbs, 3,000 IU at age 9


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Created by admin. Last Modification: Saturday February 24, 2024 22:50:32 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
17628 breathing 400 and 1000 IU.jpg admin 19 May, 2022 78.04 Kb 230
17627 RTI 400 1000.pdf admin 19 May, 2022 271.73 Kb 120