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Vitamin D provides faster recovery after muscle overuse – April 2013

Higher Serum 25-Hydroxyvitamin D Concentrations Associate with a Faster Recovery of Skeletal Muscle Strength after Muscular Injury

Nutrients 2013, 5(4), 1253-1275; doi:10.3390/nu5041253
Tyler Barker 1,tyler.barker@imail.org, Vanessa T. Henriksen 1 , Thomas B. Martins 2 , Harry R. Hill 2,3 , Carl R. Kjeldsberg 2,3 , Erik D. Schneider 4 , Brian M. Dixon 4 and Lindell K. Weaver 5,6,7
1 The Orthopedic Specialty Hospital, Murray, UT 84107, USA
2 ARUP Laboratories, Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
3 Department of Pathology, Pediatrics and Medicine, University of Utah, Salt Lake City, UT 84132, USA
4 USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA
5 Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA
6 LDS Hospital, Salt Lake City, UT 84143, USA
7 School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Received: 30 January 2013; in revised form: 18 March 2013, Accepted: 29 March 2013, Published: 17 April 2013
(This article belongs to the Special Issue Vitamin D and Human Health)

The primary purpose of this study was to identify if serum 25-hydroxyvitamin D (25(OH)D) concentrations predict muscular weakness after intense exercise. We hypothesized that pre-exercise serum 25(OH)D concentrations inversely predict exercise-induced muscular weakness. Fourteen recreationally active adults participated in this study. Each subject had one leg randomly assigned as a control. The other leg performed an intense exercise protocol. Single-leg peak isometric force and blood 25(OH)D, aspartate and alanine aminotransferases, albumin, interferon (IFN)-γ, and interleukin-4 were measured prior to and following intense exercise. Following exercise, serum 25(OH)D concentrations increased (p < 0.05) immediately, but within minutes, subsequently decreased (p < 0.05). Circulating albumin increases predicted (p < 0.005) serum 25(OH)D increases, while IFN-γ increases predicted (p < 0.001) serum 25(OH)D decreases. Muscular weakness persisted within the exercise leg (p < 0.05) and compared to the control leg (p < 0.05) after the exercise protocol. Serum 25(OH)D concentrations inversely predicted (p < 0.05) muscular weakness (i.e., control leg vs. exercise leg peak isometric force) immediately and days (i.e., 48-h and 72-h) after exercise, suggesting the attenuation of exercise-induced muscular weakness with increasing serum 25(OH)D prior to exercise. Based on these data, we conclude that pre-exercise serum 25(OH)D concentrations could influence the recovery of skeletal muscle strength after an acute bout of intense exercise.
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Takes >168 hours for the leg to recover

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Calcium spiked after the muscle stress

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Clipped from PDF

In experimental rats, vitamin D treatment accelerated the recovery in muscular strength after Injury. see VitaminDWiki Deadly amount of vitamin D speeds up recovery of crushed muscles in rats – Dec 2012
Conclusions
Muscle weakness hinders millions of people worldwide every year and is mediated by a variety of conditions, including aging, disease, inactivity, limb immobilization, repetitive use, and intense or unaccustomed exercise. In the present investigation, we reveal that muscular weakness after an intense exercise bout is abrogated with increasing serum 25(OH)D concentration prior to exercise. However, this was apparent immediately and several days (2-day and 3-day), but not 1-day, after intense exercise. Additionally, IFN-γ and albumin predicted serum 25(OH)D concentration fluctuations, and due on these fluctuations, we recommend caution when interpreting serum 25(OH)D concentrations immediately after intense exercise and/or during an acute inflammatory response. We conclude that maintaining an adequate serum 25(OH)D concentration could attenuate muscular weakness after intense exercise. Given the feasibility of increasing 25(OH)D concentrations in the blood, future research investigating the influence of diverse vitamin D interventions on the alleviation of muscular weakness after muscular insult are encouraged in humans.
PDF is attached at the bottom of this page

2nd PDF (Dec 2013) is also attached at the bottom of this page


Summary by VitaminDWiki

  • Muscle injury = 10 sets of 10 jumps with 509 pounds force using single leg
  • Subjects were not high trained athletes: < 60 minutes per session, not daily exercise

See also VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
3398 Recovery Barker - Dec 2013.pdf PDF - 2013 admin 18 Dec, 2013 13:21 448.40 Kb 919
2386 M Caclium.jpg admin 19 Apr, 2013 14:29 18.82 Kb 1234
2385 Leg took a while to recover strength.jpg admin 19 Apr, 2013 14:28 29.62 Kb 1383
2384 M3.jpg admin 19 Apr, 2013 14:28 24.38 Kb 1391
2383 M1.jpg admin 19 Apr, 2013 14:28 39.08 Kb 1431
2382 M0.jpg admin 19 Apr, 2013 14:27 29.08 Kb 1425
2381 Muscle.pdf PDF 2013 admin 19 Apr, 2013 14:27 701.61 Kb 1212
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