Effect of Vitamin D3 on Lung Damage Induced by Cigarette Smoke in Mice
Open Med (Wars). 2019; 14: 827–832, . doi: 10.1515/med-2019-0096
Xin Zheng,*,1 Nini Qu,1 Lina Wang,1 Guoli Wang,1 Rui Jiao,1 Hu Deng,1 Sijia Li,2 and Yibing Qin2
1 hour of smoke per day, 6 days a week, for 16 weeks
21 gram mice, 1,000 IU Vitamin D (daily?) (study also tried 2,000 and 3,000 IU)
A human weighs about 3,800 X more than a 21 gram mouse
Vitamin D equiv. for human would thus be 3.8 million IU – which seems very unlikely
Comments by founder of VitaminDWiki
Seems like far too much vitamin D was used by this study.
A daily loading dose of 50,000 IU each day for the first week is popular (to quickly restore vitamin D levels)
4,000 IU daily on-going for humans is popular (or 50,000 IU every 2 weeks)
IF the dose size is proportional to weight between mice and humans, then mouse doses should be~ 4000 X smaller
See also VitaminDWiki
- There are many ways of increasing vitamin D, inhaled might be best way for the lungs
- If smoke, try Vitamin D - reduce damage or help quit - 2012
Smoking reduces vitamin D - many studies contains the following
Two pathways are often proposed for how smoking decreases vitamin D:
1) Smoking decreases Calcium. and Vitamin D is used up in replacing the Calcium
2) Smoking injures the body, and vitamin D is used up in repairing the body
It appears that taking Vitamin D while smoking will:
1) Decrease the incidence of the many health problems associated with smoking - even lung cancer
2) Decrease the desire to smoke (perhaps take fewer smoking breaks?)
3) Increase breathing capacity
Opinion: If unable to stop smoking,
or are a previous smoker,
or are getting 2nd hand smoke,
increase Vitamin D and perhaps Omega-3 (which decreases depression, inflammation)
Vitamin D should also help people quit smoking See bottom of page Smoking reduces vitamin D
1) Reduces weight gain associated with quitting smoking
2) Reduces depression associated with quitting smoking
Download the PDF from VitaminDWiki
Far less inflammation @ 16 weeks in mice getting Vitamin D
Almost as low inflammation as "non-smokers"
Lung microphotograph - normal
Lung microphotograph after 16 weeks of smoke
Lung microphotograph after 16 weeks of smoke and Vitamin D
Cigarette smoking is known to induce serious lung diseases, but there is not an effective method to solve this problem. The present study investigated vitamin D3 on over-expression of CXCR3 and CXCL10 in mice induced by cigarette smoking. A pulmonary airway model was designed, and morphological assessment of emphysema, IL-4, IFN-γ and CXCL10 concentration in bronchoalveolar lavage fluids, expression of CXCR3 and CXCL10 were detected. Emphysema of the mice only exposed to cigarette smoke was significant, and concentration of IL-4, IFN-γ and CXCL10 was also increased. In addition, CXCR3 and CXCL10 were over-expressed. The degree of emphysema, concentration of IL-4, IFN-γ and CXCL10, and expression of CXCR3 and CXCL10 in mice administrated with low dose vitamin D3 were similar to the normally treated mice. Low dose of vitamin D3 can effectively protect the lung from the damage induced by cigarette smoke.
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