Table of contents
- Vitamin D Receptor Overview
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Activators of the Vitamin D Receptor
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Genetics category listing contains the following
470 VDR items - See also Vitamin D Binding Protein category listing has
169 items - In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time
- See also web
- Chart: Need more D if poor VDR (ignores VDR activation and loading dose) - Sept 2021
- PubMed
- Ways to increase the VDR - Selfhacked
- VitaminDWiki Vitamin D Receptor with CANCER in title (77 as of Aug 2022)
- VDR is associated with 49 other VitaminDWiki categories (4+ each)
Vitamin D Receptor Overview
470 studies in Vitamin D Receptor category Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
See also:
A poor VDR restricts Vitamin D from getting in the cells44 studies in the Resveratrol category It appears that 30% of the population have a poor VDR (40% of the Obese )
Health problems include: Autoimmune (
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems17 studies), Breast Cancer ( 20 studies), Colon Cancer ( 13 studies), Cardiovascular ( 22 studies), Cognition ( 16 studies), Diabetes ( 22 studies), Hypertension ( 7 studies), Infant ( 18 studies), Lupus ( 6 studies), Metabolic Syndrome ( 3 studies), Mortality ( 4 studies), Multiple Sclerosis ( 11 studies), Obesity ( 15 studies), Pregnancy ( 22 studies), Rheumatoid Arthritis ( 10 studies), TB ( 8 studies), VIRUS ( 30 studies), Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDRVDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement Sun
Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D Receptor 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor 14)Butyrate especially gut Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Activators of the Vitamin D Receptor
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc
Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activatorsVitamin D Receptor pages in VitaminDWiki with CANCER in title 76 as of Feb 2022
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
Download the VDR chapter from sci-hub via VitaminDWiki
Has the risk of Breast Cancer due to poor Vitamin D Receptor increased in past decades?
Genetics category listing contains the following
313 articles in the Genetics category see also
- Vitamin D Receptor has
470 items - Vitamin D Binding Protein = GC has
169 items - CYP27B1 has
53 items - CYP24A1 in title (32 as of Oct 2022)
- CYP24R1 25+ items
- Calcidiol has
42 items - Calcitriol has
56 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
470 VDR items - wiki page:
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Natural activators of the Vitamin D Receptor - some immune cells - April 2023
- Crohn's and Vitamin D - many studies
- Less radiation-induced intestinal injury if activate the Vitamin D receptor (mice) – Dec 2022
- Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- A healthy gut needs Vitamin D and a good vitamin D receptor – Sept 2022
- How cancer is fought by Vitamin D (Ovarian this time) - Feb 2020
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022
- Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022
- Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR – July 2022
- Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022
- Vitamin D Receptors are both inside the cell and at the cell membrane – July 2020
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
- CBD may be synergistic with Vitamin D (improves VDR in rats) - Aug 2022
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022
- An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes – June 2022
- COVID 3X more likely if a poor Receptor (cells get less Vitamin D from the blood) – July 2022
- Long-COVID is now the biggest COVID concern - many studies
- Vitamin D genes – Review June 2022
- 14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
- Poor oral bacteria associated with poor Vitamin D Receptor - June 2022
- Vitamin D metabolism and genes as of Nov 2019
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Poor vision associated with poor Vitamin D or poor Vit. D genes – June 2022
- Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022
- Genes that increase the risk of Osteoporosis: Vitamin D Receptor is number one in Asians– April 2022
- Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022
- Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022
- Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022
- BPH increased risk if poor Vitamin D Receptor in Asians – meta-analysis April 2022
- Some breast cancers may be treated RNA changes caused by Vitamin D – March 2022
- Vitamin D up and down regulates 1,000’s of genes via the Vitamin D Receptor – March 2022
- COVID death 12X more likely if poor Vitamin D Receptor (less D gets to cells) -several studies
- Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022
- 2X increase risk of Asthma if a particular Vitamin D Receptor mutation – meta-analysis Feb 2022
- Poor Vitamin D receptor reduced vitamin D levels -meta-analysis Jan 2022
- The Vitamin D Receptor is associated with many health problems
- COVID severity, ICU, and mortality all associated with poor vitamin D receptor (but not D, everyone had low D) -Dec 2021
- Different Vitamin D Receptor problems cause different COVID problems - Dec 2021
- Breast Cancer, Vitamin D, and genes – Welsh Nov 2021
- Gout 1.5 X more likely if a poor Vitamin D Receptor – 2014
- Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
- Cancers and Vitamin D Receptors, including change with race – Feb 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated
- Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021
- Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010
- Quercetin increases Vitamin D getting to cells (fights COVID, etc)
- COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021
- Little Vitamin D benefit if poor Vitamin D Receptor (400 studies annually) - Oct 2021
- Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018
- PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- The vitamin d receptor and T cell function- June 2013
- Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021
- Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Male Infertility is associated with poor Vitamin D Receptor – July 2021
- Poor male fertility is association with poor Vitamin D Receptor (less D to the cells) – July 2021
- 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
- Graves' disease 2X more likely if poor Vitamin D Receptor (like many other autoimmune diseases) – May 2021
- A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017
- Kidney stone risk varies a lot with both genetics and race – meta-analysis May 2021
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Vitamin D may also get into cells via TRPV1 (not just VDR) – April 2021
- Vitamin D Receptor and Cancer
- Non-Hodgkin’s lymphoma associated with poor Vitamin D receptor – Feb 2021
- Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021
- Oral Cancers - increased risk if low vitamin D or poor vitamin D genes
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Common sense COVID-19 risk reduction - masks, social distancing, vitamin D - Oct 2020
- AI is examining 170,000 potential COVID-19 treatments, Vitamin D is one of only 6 found – Sept 4, 2020
- Risk of Major Depressive Disorder increased 2.2 X by a poor Vitamin D receptor – Oct 2020
- Glaucoma 3.1 X more likely if a poor Vitamin D Receptor – Sept 2020
- Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020
- Mucosal membranes (mouth, lungs, nose, intestines, etc) can activate Vitamin D – July 2020
- Vitamin D genes are important, update – Sept 2020
- Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Metabolic Syndrome risk increases about 20 percent if poor Vitamin D Receptor – Aug 2020
- Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020
- Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020
- Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020
- Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020
- Some Rickets is due to poor genes - Vitamin D needed lifelong – June 2020
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- 4X less of one chemo needed after vitamin D receptor activation - June 2020
- Vitamin D, Quercetin, and Estradiol all increase vitamin D in cells and increase genes which reduce COVID-19 – May 21, 2020
- Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020
- Infant and child immunity depends on Vitamin D and two Vitamin D genes – Review April 2020
- Quercetin and Vitamin D - Allies Against COVID-19
- Vitamin D genes vary with UVB in Europe, Africa, Asia – March 2020
- Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- How cancer is fought by Vitamin D (Ovarian this time) – Feb 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020
- Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019
- Depression associated with poor Vitamin D Receptor (in mice) – Dec 2019
- Does survival of the less fit mean less health (poor genes may be inherited)
- 1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019
- Autoimmune disease treated by Vitamin D, Zinc (and other activators of Vitamin D Receptor) – Oct 2019
- Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019
- Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019
- Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis Dec 2019
- Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019
- Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015
- Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019
- Restless Leg Syndrome linked to brain genes associated with Vitamin D and Iron – Nov 2019
- Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
- Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
- Prevent Osteoporosis and Have Strong Bones - book 2013
- Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019
- Liver Cirrhosis death is 4X more likely if poor Vitamin D Receptor – Sept 2018
- Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
- Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019
- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019
- Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019
- Leprosy risk is reduced by 3X for some types of Vitamin D Receptor (Brazil) – Sept 2019
- Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Helicobacter pylori infection and low vitamin D – several studies
- Gastric Tissues and Vitamin D Genes – Aug 2019
- Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019
- Autoimmunity problems often associated with poor Vitamin D Receptors – March 2019
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Vitamin D Receptor, the gut, the immune system, and the Middle East – May 2019
- Vitamin D Receptor - activation and deactivation- self-hacked June 2019
- MRSA Carriers not helped by 4,000 IU of Vitamin D (probably poor Vitamin D Receptor) – RCT Sept 2018
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- TB patients had low Vitamin D and poor Vitamin D receptor – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Mechanisms of vitamin D action in skeletal muscle – June 2019
- Lumbar disc degeneration 30 percent more likely if poor Vitamin D Receptor – May 2019
- Vitamin D Receptor synonyms
- Blood cell cancer is associated with a 3X worse Vitamin D Receptor – June 2019
- Vitamin D Receptor described at US National Library of Medicine
- Inflammatory bowel disease, gut bionome and Vitamin D Receptor – 2018
- Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019
- TB and Leprosy are easily confused and associated with Vitamin D Receptor
- Lyme disease appears to massively deactivate the Vitamin D Receptor - 2019
- Best supplements for hay fever (Quercetin, which activates the Vitamin D receptor) - June 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Multiple Sclerosis and Vitamin D Receptor super enhancers – March 2019
- Active Lupus associated with 3.8 X less activated Vitamin D Receptor – May 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Vitamin D Receptor summary
- U.S. healthcare system (and its investors) are really good at monetizing illness, but not wellness – May 2019
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019
- Curcumin may increase Vitamin D in tissues (activates Vitamin D Receptor) – Dec 2010
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019
- Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018
- Good Vitamin D receptor reduced bladder cancer and cisplatin deaths – April 2019
- Graves' disease 1.4 X more likely if poor Vitamin D Receptor – March 2019
- A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019
- Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Breast Cancer and Vitamin D review – March 2018
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- World's Top Authors in Vitamin D, VDR, Vitamin K, Omega-3, etc - Jan 2019
- Some essential oils improve health by improving the vitamin D receptor – March 2018
- Sleep Apnea 1.8 X more likely if poor Vitamin D Receptor – Dec 2018
- Gut and airway bionome are affected by Vitamin D and Vitamin D Receptor – Nov 2018
- Osteoporosis 15 percent more likely if poor Vitamin D receptor – meta-analysis Dec 2018
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Vitamin D receptor mutations might cause hereditary vitamin D-resistant rickets – March 2015
- Body may change gene activation if more Vitamin D is needed by tissue (Schiz. in this case) – Oct 2018
- Impaired Vitamin D Sensitivity (Vitamin D Receptor) – Nov 2018
- Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018
- Severe hand, foot, and mouth virus is 2.9 X more likely if poor Vitamin D receptor – Oct 2018
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- Ovarian Cancer risk reduced if higher vitamin D, more UVB, or better vitamin D receptor – Nov 2018
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Maps of where Vitamin D studies are published and keywords used – Jan 2018
- Hepatitis B virus reduced by 5X the Vitamin D getting to liver cells in the lab – Oct 2018
- Resveratrol improves health (Vitamin D receptor, etc.)
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Many health risks associated with low Vit D or poor Vitamin D Receptor – more RCT needed – March 2018
- Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Pancreatic Cancer – live a year longer if have high vitamin D and good Vitamin D Receptor – Aug 2018
- Some enveloped virus are 1.2 X more likely if have a poor Vitamin D Receptor -Aug 2018
- Endometriosis, Endometrial Cancer, and poor Vitamin D or Receptor – Aug 2018
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Obesity might be related to Vitamin D genes – July 2018
- Vitamin D Receptor and autoimmune diseases – Jan 2017
- Risk of colon cancer increases in mice with no Vitamin D receptor in colon - July 2018
- Sudden kidney infection in children was 9X more likely if poor Vitamin D receptor – July 2018
- Vitamin D2 and Calcipotriol (psoriasis drug) increase Vitamin D3 getting to cells – June 2018
- Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018
- ADHD associated with both low vitamin D and poor Vitamin D receptor – May 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Vitamin D receptor is essential for both normal and cancerous cells in the lab – June 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- Adolescent idiopathic scoliosis 2 X more likely in Asians with poor Vitamin D Receptor
- Thyroid and vitamin D are the only body components which have a receptor on every cell in the body
- Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico) – April 2018
- Vitamin D receptor is activated somewhat by ginger, thyme, coriander, and lemongrass – March 2018
- Lumbar Degenerative Disc Disease 3X more likely if poor Vitamin D Receptor – March 2018
- Active Vitamin D reduces Ovarian Cancer stem cells growth by 4X (via Vitamin D receptor in lab rat) – March 2018
- Vitamin D gene expression varies with Epileptic age – March 2018
- Metabolic Syndrome risk increases about 70 percent if poor Vitamin D Receptor
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018
- Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008
- Disc Degeneration in women is 1.7X more likely if poor Vitamin D Receptor – meta-analysis Jan 2017
- Do you have a Vitamin D Receptor Mutation (and might need more vitamin D) – Jan 2018
- Degeneration of lumbar disc 2.5 X more likely if poor Vitamin D receptor (not detected by test) Feb 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Leprosy, low Vitamin D and poor Vitamin D Receptor
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Increased occurrence of Graves' and Hashimoto's diseases if poor Vitamin D genes – Nov 2014
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Olmesartan (blood pressure drug Benecar) improves Vitamin D Receptor by an unknown amount
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Weaker hand grip if poor Vitamin D Receptor (15 percent) – Nov 2016
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Brain may deal with all forms of Vitamin D (rat brain) – Sept 2017
- Lumbar degenerative disc diseases can be prevented via Vitamin D Receptor – many studies
- Review of 11 Vitamin D genes – Nov 2017
- Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria
- Glucocorticoid treatment reduces Vitamin D getting to cells via 3 or 4 genes
- TB risk in Blacks increased 20 percent having poor Vitamin D Receptors – Sept 2017
- Vitamin D receptors not detected in some tissues – July 2012
- Nonmelanoma Skin Cancer 2X more likely if poor Vitamin D Receptor – Oct 2017
- UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Familial Mediterranean Fever is 3X more likely if poor Vitamin D Receptors (males) – Sept 2017
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Speculation – Weekly vitamin D dose will be better than daily if poor Receptor
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Thyroid Cancer rate has increased 3X in 3 decades, Vitamin D Receptor decreases, Calcium increases – Aug 2017
- Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017
- Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Raised skin scars (keloid) have fewer Vitamin D Receptors – Aug 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Cancer risks and Vitamin D Receptors – association is unclear – 2017
- Aging leads to a decrease of vitamin D getting to cells – Sept 2017
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
- Ulcerative Colitis – half have poor level of Vitamin D Receptor vs only one in ten normally – June 2017
- Prostate surgery outcomes vary with Vitamin D Receptors– May 2017
- Gastric Cancer 2.7 X more likely if poor Vitamin D Receptor (Chinese) – 2015
- Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017
- Skin Cancers, Vitamin D, Vitamin D Receptor and Genes – Jan 2015
- The vitamin D receptor (publisher wants 10 dollars for this update) – Feb 2017
- Vitamin D Receptor problems occur 5 times for often with Nasal polyposis – Nov 2016
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- 2X more likely to survive a form of esophageal cancer in China if have good vitamin D receptor – Feb 2017
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Urinary Bladder Cancer survival is associated with vitamin D receptor: 14 months vs 53 months – Oct 2015
- Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D effects on lung immunity and respiratory diseases – 2011
- Sunshine vitamin and thyroid - Jan 2017
- Vitamin D receptor has 1496 variants – Dec 2016
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- Vitamin D - Binding Protein, Receptor, enzymes and health benefits - review Jan 2016
- Vitamin D Receptor and Obesity – several studies
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Herpes (Cytomegalovirus) downregulates the vitamin D receptor by 8X – Jan 2017
- Vitamin D, Vitamin D Receptor and Cancer – Nov 2016
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies
- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
- PCOS (polycystic ovary syndrome) 4 times more likely if poor Vitamin D Receptor – Dec 2015
- Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Ulcerative colitis associated with both low Vitamin D and poor Vitamin D Receptors – Oct 2016
- Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016
- Severe Pertussis is 1.5 times more likely if poor vitamin D receptor – Feb 2016
- Myopia 2 times more likely if Vitamin D Receptor problem – June 2011
- Vitamin D (and VDR) – Vieth book chapter - 2017
- Vitamin D Receptor test for 29 dollars (there are 5 more Vitamin D genes) – Oct 2016
- Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016
- Chronic Periodontitis 9.6 times more likely if smoke and have poor Vitamin D Receptor – Aug 2016
- Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies
- Dental carries associated with poor vitamin D receptor (TaqI genotypes) – 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Autism 2X more likely with Vitamin D Receptor problems – many studies
- Dengue Fever associated with poor vitamin D receptor – July 2002
- Vitamin D Receptor Activator might help treat or prevent various diseases
- Health problems that run in families are often associated with low vitamin D
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016
- Vitamin D actions which are faster than gene interactions – March 2016
- Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016
- Dengue virus 2X to 4X more likely if vitamin D receptor gene problems
- Vitamin D dose size needed – VitD testing tells only a portion of the story – Jan 2016
- Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015
- Osteoporosis is associated with more than vitamin D genes – Jan 2016
- Genes and Vitamin D – literature review – Dec 2015
- Vitamin D and the skin: Focus on a complex relationship - Nov 2015
- Vitamin D Receptor locations – Dec 2012
- Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Vitamin D Receptors can be activated by other than Vitamin D - March 2015
- Different response by Vitamin D Receptor to Vitamin D vs Vit. D analogs – Sept 2015
- Some of Us May Need More Vitamin D Than Others - Sept 2015
- Vitamin D Receptor and immune differences between mice and men – Sept 2015
- Vitamin D receptor genes vary a lot between races – Dec 2015
- Uterine Fibroids (uterine leiomyoma, need hysterectomy) 1.9 more likely if a Vitamin D receptor problem – Sept 2015
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015
- Benefits of Vitamin D often limited by genes
- 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
- Intense exercise increases vitamin D receptor activation
- 2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015
- Vitamin D receptor functionality improved with probiotics – Sept 2015
- Hypothesis Vitamin D receptor controls PTH without needing Vitamin D – Aug 2015
- Vitamin D Receptor
- Vitamin D Receptors are important for health (technical)– May 2015
- Genes in the blood are not static, 20 percent change with the seasons - such as Vitamin D Receptor – May 2015
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Leprosy associated with changes to Vitamin D receptor genes (VDR)– April 2015
- Progesterone activates vitamin D receptor - many studies
- Vitamin D Receptor – environment, genetics and epigenetics – May 2015
- Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems
- Health outcomes of vitamin D. Parts I (VDR) and II – 2014
- Diseases, Vitamin D Receptor and other genes – June 2014
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
- Resveratol helps vitamin D bind to cells
- Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014
- Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
- Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014
- Pancreatic Cancer treatment by calcipotriol (a synthetic vitamin D) improves outcome by 57 percent – Sept 2014
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Hypertension, Vitamin D Receptor, and FokI gene – Editorial Aug 2014
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
- Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014
- Vitamin D Receptor can be modulated with a new compound – Feb 2014
- 10 reasons why seniors need more vitamin D
- 2,776 vitamin D receptor binding sites - April 2014
- Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014
- Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
- The Overlooked Importance of VITAMIN D RECEPTORS - LEF Aug 2013
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- Vitamin D receptor may suppress skin cancer – Dec 2013
- Perhaps a sunshine option for chronic liver disease – Nov 2013
- Surprise:Three different types of vitamin D can activate the vitamin D receptor – Oct 2013
- Endometriosis treated, and perhaps prevented, by vitamin D - many studies
- Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
- Liver and interactions with vitamin D deficiency - Review July 2013
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
- The vitamin D receptor and T cell function – June 2013
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
- Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels – July 2012
- Rheumatoid arthritis, genes and vitamin D – May 2013
- Vitamin D is suppressed by both Roundup and Genes
- Spinal disc degeneration is associated with vitamin D receptor genes, and others – March 2013
- Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc.
- Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- Calcium and vitamin D receptors are important to many health conditions – Jan 2013
- Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
- Genetics
- Vitamin D levels are strongly associated with genes: overview of twin studies – Nov 2012
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- 2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012
- Hodgkin’s lymphoma and Vitamin D Receptor - June 2012
- Hours of sun per week decreased probability of NH lymphoma by 32 percent – April 2012
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
- Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012
- Vitamin D receptor activation and Chronic Kidney Disease – Oct 2011
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
- Genes breast cancer and vitamin D receptor - Sept 2010
- 229 Genes related to vitamin D - Aug 2010
- Vitamin D Receptor technical details – Jan 2010
- Potential for vitamin D receptor agonists in the treatment of cardiovascular disease
See also Vitamin D Binding Protein category listing has
169 items
In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time
Note: Many people have Herpes but are not aware of it. (example: 48% of black women)
See also web
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
Pathogens That Inhibit The Vitamin D Receptor include
P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
Aspergillus fumigatus – In cystic fibrosis patients,
Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017 - Changes in vitamin D endocrinology during aging in adults June 2017
- "Aging leads to a decrease in vitamin D receptor number in several organs."
Interesting, details are behind a paywall - Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
Download the PDF from VitaminDWiki - Calcitriol receptor = VDR Wikipedia
"Glucocorticoids are known to decrease expression of VDR,"
"Mutations in this gene are associated with type II vitamin D-resistant rickets"
"The vitamin D receptor plays an important role in regulating the hair cycle." - Learn more about Calcitriol Receptor Science Direct.COM
10 abstracts of book chapters and studies - Calcitriol ReceptorWikipedia
"Mutations in this gene are associated with type II vitamin D-resistant rickets"
"Calcitriol, the active form of vitamin D, binds to the VDR, which then forms a heterodimer with the retinoid-X receptor"
perhaps this is where Vitamin A is important with Vitamin D
"Glucocorticoids are known to decrease expression of VDR"
Chart: Need more D if poor VDR (ignores VDR activation and loading dose) - Sept 2021
1 minute video description of the chart
PubMed
Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.OBJECTIVES:
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects.METHODS:
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.RESULTS:
Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r2 = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density (P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased (P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased (P = .007 and .04 respectively). Multivariate modeling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation (R2 = 0.34, P < .0001).CONCLUSIONS:
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.PMID: 28432711 DOI: 10.1002/ajhb.23010
Publisher rents PDF for $6
More and more PubMed papers on Vitamin D Receptor
- Vitamin D and VDR in Gynecological Cancers—A Systematic Review - Dec 2017
Download the PDF from VitaminDWiki - Heart failure and vitamin D receptor gene Nov 2016
10.1016/j.clnu.2016.11.010 Download the PDF from Sci-hub via VitaminDWiki
- The frequency distribution of vitamin D Receptor fok I gene polymorphism among Ugandan pulmonary TB patients
July 2016 - free PDF online - Vitamin D receptor-targeted treatment to prevent pathological dedifferentiation of pancreatic β cells under hyperglycaemic stress
https://doi.org/10.1016/j.diabet.2017.07.006 Sept 2017 - details are behind a paywall
Download the high technical PDF from Researchgate via VitaminDWiki
Ways to increase the VDR - Selfhacked
Vitamin D Receptor Gene: Ways to Activate it, Calcitriol, Benefits Self-hacked.com Aug 2018
A list of ways to Increase EITHER active Vitamin D or Vitamin D Receptor
Following subset list May include some non-VDR items by mistake
See self-hacked article for hyperlinks and details- RXR (and retinol) is needed to produce proteins with the VDR. 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR dependent genes need RXR.)
- SIRT1 -potentiates VDR [R, R] – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
- PGC-1a [R]– potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
- Dopamine [R]
- The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver-derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitate disposal from the cell via the ABC efflux transporter [R].
- Omega-3: DHA, EPA [R], – Fish oil/DHA
- Omega-6: γ-Linolenic acid, Arachidonic acid [R],
- Curcumin [R]– Curcumin is more active than LCA/Bile in driving VDR-mediated transcription and that it binds to VDR with approximately the same affinity as LCA.
- Resveratrol [R] – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
- Gamma Tocotrienol [R]- Tocotrienols or Tocopherols (IHERB)
- Estradiol increases VDR expression [R, R] and calcitriol levels [R].
VitaminDWiki Vitamin D Receptor with CANCER in title (77 as of Aug 2022)
This list is automatically updated
Items found: 81
VDR is associated with 49 other VitaminDWiki categories (4+ each)
Click here for association information
Summary of Associations
Associated category Associations Results
7 pages in both categories: Vitamin D Receptor + Thyroid and parathyroid
9 pages in both categories: Vitamin D Receptor + Cancer - Other
67 pages in both categories: Vitamin D Receptor + Genetics
42 pages in both categories: Vitamin D Receptor + Vit D Binding Protein
17 pages in both categories: Vitamin D Receptor + Resveratrol
6 pages in both categories: Vitamin D Receptor + Dental
13 pages in both categories: Vitamin D Receptor + Cancer - Colon
8 pages in both categories: Vitamin D Receptor + Seniors
21 pages in both categories: Vitamin D Receptor + Top news
13 pages in both categories: Vitamin D Receptor + Gut
23 pages in both categories: Vitamin D Receptor + Breathing
12 pages in both categories: Vitamin D Receptor + Osteoporosis
16 pages in both categories: Vitamin D Receptor + Cognitive
7 pages in both categories: Vitamin D Receptor + Skin - Dark
7 pages in both categories: Vitamin D Receptor + Cancer - Prostate
10 pages in both categories: Vitamin D Receptor + Parkinson
5 pages in both categories: Vitamin D Receptor + Cancer - after diagnosis
21 pages in both categories: Vitamin D Receptor + Cancer
22 pages in both categories: Vitamin D Receptor + Pregnancy
4 pages in both categories: Vitamin D Receptor + Autism
30 pages in both categories: Vitamin D Receptor + Virus
- Vitamin D Binding Protein = GC has
- See also Vitamin D Binding Protein category listing has