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Vitamin D, now conclusive (for COVID) - Dr. Campbell Video and transcript - Feb 1, 2023


"Vitamin D, now conclusive"

YouTube 14 minutes

Transcript

Vitamin D cut death in half,
Unethical to not suggest take Vitamin D

0:00:01.4 A warm welcome to today's talk. It's Wednesday the 1st of February. Now, we now know that vitamin D supplementation provides substantial benefit in terms of reducing the risk of admission to intensive care during the Coronavirus pandemic.

  • 72% is the probable figure, certainly substantial, and it probably also gives us a
  • 51% protection against death, Vitamin D supplementation.

Now on this channel, we've been talking about Vitamin D since we started the channel in 2007, a long time ago now, and we've been talking about it throughout the COVID pandemic period of time. Now, we have this new meta-analysis from Italy, definite protection against admission to intensive care for patients that are ill or hospitalized. I now believe it's unethical for authorizing bodies, Medicines and Healthcare Regulatory Authority and FDA and people like this around the world, not to advise vitamin D supplementation for poorly people and arguably for the whole population.

"Vitamin D is about as safe as cabbage"

0:01:08.5 I believe it's now unethical that they don't do that, but they're not doing that. They are recommending treatments that are less efficacious, but they're not recommending vitamin D. And vitamin D is safe and effective. We've gotta be careful how we use the term "safe," but vitamin D is about as safe as cabbage or eating anything else. It's just a nutrient, but we get it from the sunshine. And that's why we're short of it. We're short of it in the northern hemisphere over winter because we don't get it from the sun. That's why we need to supplement it. Personally, at the moment, I'm taking 4000 units of vitamin D a day. That's 100 micrograms, and I take that in combination with 100 micrograms of vitamin K2 as well.

Meta-analyses on Vitamin D and COVID - but not the US, UK, etc. - Why?

0:01:50.7 So let's look at the evidence here because it is now definitive. It's from this paper here, and it's an Italian paper, leading Italian doctors and scientists. Why is it that all this work comes from places... We're gonna be looking at work today from Spain, Saudi Arabia, Italy, nothing from the United States, nothing from the United Kingdom. Why not? It really begs that question, "Why not?" Anyway, this is the paper here, all available, download it for yourself, PDFs available. VitaminDWiki - COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis Jan 2023. Now this trial sequential analysis is sort of an add-on to meta-analysis, and it allows us to account for the degrees of uncertainty in the data and to make predictions based on that. So it's really quite clever. Thankfully, it's all done by computer. There's programs to do it.

0:02:45.5 Anyway, this is in Italy. So various studies have shown this association between vitamin D deficiency and bad outcomes. Vitamin D plays a crucial role in immune function and inflammation. Simple statement of fact. Recent data suggests the protective role of vitamin D against bad outcomes. That's what this study is about, and it found out, yes, it does protect. This is what we call a nutraceutical approach. So nutrients, using nutrients as pharmaceuticals. It's a term I like. Now, of course, a lot of nutrients are necessary because if we're short of nutrients, then the immune system's not going to be optimized and not work in a proper way, but vitamin D as well as optimizing the immune system actually has additional benefits in protecting against infection and also protecting against excessive inflammation of cytokine storms.

Anti-inflammatory, antioxidant, modulates immune system, pulmonary barrier

0:03:37.0 So, production promote the immune response and reduce the inflammatory response. We know it does that, anti-inflammatory. It's also antioxidant. When you really produce a lot of waste free radicals, and so to mop those up with antioxidants is a really good idea. And it also has immunomodulatory properties. This is now beyond speculation. We are now in the realms of definitive science in terms of these activities of vitamin D. Now, immune boosting and optimizing immune function. Vitamin D maintains pulmonary barriers, so the organism's less likely to get in the first place, in this case, SARS-CoV-2, but we now know that this works against a whole range of viruses and probably bacteria as well.

0:04:21.4 This is for everything. COVID, yes. This data shows that it provides a 72% protection against admission to intensive care in SARS-CoV-2 infection, but it also works against a wide range of other infections. We have to use this more widely. Determines the production of antimicrobial peptides. Peptides are small proteins. Enhances neutrophil activity, essentially white blood cell, of course, and shifts the adaptive immune response to more T helper cells, T helper 2 cells. T helper cells promote all aspects of immunity. T helper cells are a bit like a conductor. They conduct the immunological orchestra and promote all sorts of immune function.

Cytokines: Reduces pro-inflammatory AND Increases anti-inflammatory

0:05:11.9 Anti-inflammatory effects. Now this is interesting. "Vitamin D, adequate vitamin D reduces the production of pro-inflammatory cytokines and increases the production of anti-inflammatory cytokines." So these are interleukins, various interleukins. These ones are pro-inflammatory. They increase inflammation, so vitamin D reduces their production. These ones here are anti-inflammatory cytokines, so the anti-inflammatory cytokines, their production is increased. So it reduces the production of pro-inflammatory cytokines, and it increases the production of anti-inflammatory cytokines. So we don't get these cytokine storms that have been killing people. The lower the vitamin D at baseline, the more effective it is. Just think of all those poor people that died in nursing homes that had been stuck inside for the last year or two, hadn't been exposed to any sunshine. Their vitamin D levels would be in their boots.

0:06:13.7 And basically there was no substantial supplements given despite what we were calling for very early on in the pandemic. High-risk interventions were carried out, very, very safe interventions like vitamin D, zinc, basically ignored. It really is a scandal. It's a total scandal, absolute disgrace. Reduces asthma exacerbations, prevents acute respiratory infections, we believe of all sorts, certainly influenza as well as COVID and influenza now. So we need to optimize the population's vitamin D levels to reduce influenza. And it reduces the complications of infections.

Other Vitamin D and COVID studies
"Why is this not being shouted from the rooftops by our regulatory authorities"

0:06:53.6 Now, as well as that, this is another study here, a COVID-19 and vitamin D Systematic Review, another systematic review. The rates of positivity in the tests were significantly decreased in the intervention group as opposed to the non-intervention groups. So the PCR tests were less likely to be positive. So vitamin D is actually protecting against infection here, relative risk, 0.46. So that's what? A 54% protection against infection in the first place. "Better than other treatments which are currently being recommended." Why is this not being shouted from the rooftops by our regulatory authorities, who I believe now are acting unethically in not giving this advice.
Conclusively, this paper says "That COVID-19 patients supplemented with vitamin D, fewer rates of ICU admissions, less mortality, and less positivity." Well, beyond the realms of speculation here.

0:08:07.5 Meta-analysis and trial sequential analysis, now this is getting back to the original paper that we're looking at. So they want to better explain the strength of the associations, which they can do of the protective role of vitamin D supplement. And as we've said, they were examining risk of mortality and admissions to intensive care unit. This data was collected as a snapshot on 20th September, 2022. So it was what information was available then. And they did all the risks of assessment. Now, how to adjust thresholds for significance in random clinical trials when the required sample size has not been reached. That's this new trial sequence analysis bit that was added on.

0:08:49.2 So it adjusts the threshold of significance. So it works out how significant the result is, depending on the sample size. And of course being a meta-analysis, it pulled all the samples as well, got to samples that were definitively big enough and they definitively said it protects against intensive care admissions. We basically know this now. Now, they looked at quite a few papers originally, but they settled on five main randomized trials. And here's the results. As we've said, vitamin D administration, reduced risk of death 0.49. That's a 51% protection, isn't it? And, against death and vitamin D administration resorted in a decreased risk of ICU admission 0.28. And as we said, that's a 72% protection.

0:09:39.3 Why is this not being used? Protective role of vitamin D and ICU admission. The trial sequence analysis of the protective role of vitamin D and ICU admission showed that since the pooling of the studies reached the definitive sample size, so as the definitive sample size was reached, the positive association is conclusive. This is conclusive according to this paper carried out in Italy, not carried out in the States, not carried out in Europe. Sorry, not carried out in Canada chuckle or Australia or New Zealand. We're getting left behind folks. We're getting left behind.

0:10:25.6 Now the studies, this was the first study here, interventional study. That one was... And for the links, check on all these. I'm not making this up. Check it out. Conducted in Saudi Arabia. Next study was this one, calcifediol. Now the calcifediol is the already activated form. So as you probably know, when vitamin D is produced in the skin or taken by mouth, it must go to the liver. It's activated into calcifediol. That's the more active form. So if you want it to work more quickly in someone that was already ill, we can give calcifediol instead of the vitamin D. It'll be activated much quicker because sick people can't wait.

0:11:05.3 So again, this could be used much more than it is. Why isn't it being recommended? Anyway, that study was done in Spain, not the English-speaking countries. This next paper was also done in Spain. This next paper was also done in Brazil. And the final study they used was in Spain. Now, why is this not being used despite the definitive evidence conducted from this paper? Why is it not being advised? Why is it not being shouted from the hilltops? I'm gonna show you that in a minute. chuckle

UK Medicines and Healthcare Products Regulatory Authority - 86% industry funded

0:11:44.9 Well, on a completely separate topic, Medicines and Healthcare Products Regulatory Authority in the United Kingdom is 80% industry-funded. Of course, they have no vested interest. This is the national body that represents medicine advisors, medicines and healthcare products throughout all of the United Kingdom. And it's 86% industry-funded. Coincidentally, vitamin D, which is basically free, it's dirt cheap and is essentially completely safe is not recommended. Other interventions which are associated with high levels of risk are recommended, 86% industry-funded. When is this going to be addressed? This is outrageous. Now, I didn't mean to flash that before, but this is just a random street scene in Manhattan. So let's look at a random street scene now in Manhattan. Looks like a bit of a van, a few pictures on it. Oh, look, it's outside Pfizer world headquarters. I believe this video has veracity.

0:13:19.7 Strange this is outside Pfizer world headquarters. Anyway, in a completely separate matter, let's hope there's not a scandal of massive consequence and intercontinental implications brewing in Manhattan. More on that tomorrow for now. Sorry, a bit overemotional today. I do try and keep it cognitive, but it just gets to you from time to time. Things that we could, should be doing, we don't bother. Then again, vitamin D is cheap, so why the heck should we? I've said enough. I'm gonna leave it there. Thank you so much for watching.


Notes and references on YouTube

https://www.ncbi.nlm.nih.gov/pmc/arti... (Italy) Various studies, a association between severe vitamin D deficiency and bad COVID-19 outcomes. Vitamin D plays a crucial role in immune function and inflammation. Recent data suggest a protective role of vitamin D against bad outcomes Nutraceutical approach Promote the immune response and reduce the inflammatory response Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D Immune optimisation and immune boosting Vitamin D maintains pulmonary barrier function Determines the production of antimicrobial peptides Enhances neutrophil activity Shifts the adaptive immune response to a more T helper cell-2 type Anti-inflammatory effects of vitamin D Reduces the production of pro-inflammatory cytokines, such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma Increases production of anti-inflammatory cytokines, such as IL-4, IL-5, IL-10 Patients with a low baseline vitamin D, more benefit Reduce risk of asthma exacerbations Prevents acute respiratory infections, and reducing their complications COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials https://www.ncbi.nlm.nih.gov/pmc/arti... The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46) Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity. Meta-analysis and trial sequential analysis (TSA) Better explain the strength of association Protective role of vitamin D supplementation, and risk of mortality / admission to intensive care units We searched four databases on 20 September 2022. Screened the randomized clinical trials (RCTs) Assessed the risk of bias (how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached) The pre-specified outcomes of interest Mortality and ICU admission 78 bibliographic citations Five RCTs were suitable for our analysis Results Vitamin D administration results in a decreased risk of death, 0.49 Vitamin D administration results in a decreased risk of ICU admission, 0.28 Protective role of vitamin D and ICU admission The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive. The studies Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial https://www.mdpi.com/2072-6643/13/7/2170

(Saudi) Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study https://www.ncbi.nlm.nih.gov/pmc/arti...

(Spain) Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D https://www.ncbi.nlm.nih.gov/pmc/arti...

(Spain) Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 https://www.ncbi.nlm.nih.gov/pmc/arti...

(Brazil) Calcifediol treatment and COVID-19-related outcomes https://www.ncbi.nlm.nih.gov/pmc/arti...

Medicines & Healthcare products Regulatory Agency https://www.bmj.com/content/377/bmj.o... 86% industry funded


46 VitaminDWiki pages with TRANSCRIPT in the title

This list is automatically updated

Items found: 67
Title Modified
Dr. Hollis Vitamin D interview and transcript (works great, but no profit) - July 2024 17 Jul, 2024
Dr. Holick interview with transcript - May 2024 05 May, 2024
Prostate Cancer - interview of Dr. Holick by Baggerly - video and transcript Jan 2024 05 May, 2024
Vitamin D Danger - Women need 70 ng for optimal Estrogen - video and transcript Dec 2023 08 Jan, 2024
The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023 03 Dec, 2023
Benefits of Omega-3s - video and transcript - Patrick - Nov 2023 29 Nov, 2023
The Dangers of Vitamin D Deficiency (and why you should supplement), Video and transcript, Patrick - Nov 2023 29 Nov, 2023
Should You Take A Vitamin D Supplement - Dr Holick transcript Oct 2022 28 Nov, 2023
End of Alzheimer's videos, transcripts and many studies 17 Nov, 2023
Vitamin D - Dr. McCullough videos and transcript Aug 2023 10 Nov, 2023
Number 1 Vitamin D Danger You Absolutely Must Know! - with transcript Nov 2023 04 Nov, 2023
COVID fought by Vitamin D - video review of literature with transcript - Dec 2021 29 Sep, 2023
Interview and transcript: Vitamin D protocol for Autoimmune diseases – Dr. Coimbra 2016 24 Sep, 2023
The ONLY Solution to Long COVID (Vitamin D) - video and transcript Sept 2023 12 Sep, 2023
Alzheimer’s Is Now Optional - Dr. Bredesen video and transcript Sept 2023 12 Sep, 2023
UK MP talked on vaccine harms, other MPs left – transcript Mar 17, 2023 24 Aug, 2023
Steroids treating ARDS was published before COVID, but was ignored – Transcript Aug 20, 2023 21 Aug, 2023
Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023 02 Aug, 2023
The INSANE BENEFITS of Vitamin D and How To Get It SAFELY - video and transcript July 2023 28 Jul, 2023
Health can be greatly improved by weekly 50,000 IU of Vitamin D - video and transcript - March 2023 01 Apr, 2023
The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 12 Mar, 2023
Vitamin D, now conclusive (for COVID) - Dr. Campbell Video and transcript - Feb 1, 2023 04 Feb, 2023
Mechanisms of Autoimmunity – video and transcript – Beltran Nov 2022 02 Jan, 2023
Vitamin D dosing varies with genes, PTH, Mg, Vit K, etc – video and transcript Sept 2022 29 Dec, 2022
The Real Story on Vitamin D: interview and transcript – Grant Dec 2022 10 Dec, 2022
Interview with transcript concerning UVA, UVB, and health – Grant Dec 2012 09 Dec, 2022
COVID US deaths: 116,000 fewer if everyone had been taking Vitamin D – Campbell transcript Nov 2022 21 Nov, 2022
Moving Vitamin D Research into Practice - Video and transcript - Baggerly - Oct 2021 12 Oct, 2022
COVID infection might prevent infection better than vaccinations - transcript and many studies 11 Oct, 2022
Debunking Misinformation About Vitamin D - Grant podcast and transcript - Sept 2022 21 Sep, 2022
Vitamin D and COVID - satirical comedy (with transcript) by Jimmy Dore - Aug 2022 08 Aug, 2022
4 X fewer visits to Dr. after getting high level of vitamin D (Interview with transcript) - Jan 3, 2022 17 Jul, 2022
Interview with transcript of Dr. Grant on Vitamin D and Cancer by Dr. Moss - June 2022 23 Jun, 2022
Boost Your Immune System, Fight Viruses - Medcram with transcript - Oct 29, 2021 22 Jun, 2022
Transcripts in VitaminDWiki 22 Jun, 2022
Vitamin D reduces autoimmune disease - Dr. Campbell video and transcript - May 2022 30 May, 2022
Wonders of Vitamin D - Renu Mahtani video and transcription - Feb 2022 12 Mar, 2022
VitaminDWiki interview and transcript - Jan 2022 01 Mar, 2022
Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 23 Feb, 2022
Vitamin D and COVID - Davies, Benskin (Dark Horse video with transcript) - Dec 27, 2021 29 Dec, 2021
PhD working at VAERS on problems with vacc system - Masterjohn interview and transcript- Dec 27, 2021 27 Dec, 2021
Dr. McCullough on COVID-19: vaccine problems, home treatment – video, slides, transcript – Oct and Dec 2021 22 Dec, 2021
Vitamin D and a Dr. in Israel - Campbell video and transcript - Dec 11, 2021 13 Dec, 2021
Omega-3 decreases heart disease and COVID: Harris and Patrick, video and transcript - Dec 2021 07 Dec, 2021
Vitamin D probably has a Role in Cancer, CVD, and COVID - video and transcript Dec 1, 2021 02 Dec, 2021
Discussion of COVID and 50 ng of Vitamin D (video and transcript)– Dr. Campbell Nov 17, 2021 19 Nov, 2021
End of Alzheimer's video and transcript - Oct 2021 09 Nov, 2021
Vitamin D and Health video with transcript - Dr. Grant Sept 2021 11 Sep, 2021
In-home testing of viral load, etc. Dr. Topol interview with transcript – Aug 11, 2021 14 Aug, 2021
Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 07 Aug, 2021
COVID-19 doctors not allowed to use treatments that work - Dr McCullough Video and transcript May 2021 11 Jul, 2021
Problems with vaccine use during a pandemic - Dr. Bossche interview with transcript - April 22, 2021 28 May, 2021
Vitamin D fights many health symptoms, including COVID-19: Dr. Mahtani video and transcript - April 2021 23 Apr, 2021
Vitamin D, COVID - Campbell and Davis (Video with transcript) - Jan 18, 2021 21 Apr, 2021
Autoimmune and high-dose vitamin D (Dr. Coimbra) - Dr. Mahtani video and transcript - Nov 2020 11 Apr, 2021
The Health Benefits of Vitamin D and Solar UVB (video and transcript) - March 2021 27 Mar, 2021
COVID public health messages 1, 2, and 3 should be - vitamin d vitamin d, vitamin d (video and transcript) - Mar 5, 2021 16 Mar, 2021
Vitamin D Help Us Fight Infections - interview of Dr. Thakkar (transcript) Jan 20, 2021 24 Jan, 2021
COVID-19 Vitamin D: Overview by Dr. in Sri Lanka (Video and transcript) - Dec 8, 2020 26 Dec, 2020
COVID-19 Vitamin D: Overview of Evidence by Dr. Seheult (Video and transcript) - Dec 10, 2020 14 Dec, 2020
Vitamin D Toxicity - an unmerited fear - Renu Mahtani video and transcription - Oct 2020 10 Oct, 2020
Dr. Coimbra on Coronavirus and Vitamin D (English transcript) - Jan 2020 31 Jan, 2020
Dr. Sears podcast with Carole Baggerly about Vitamin D (with transcript) - July 2019 05 Jul, 2019
Vitamin D, trauma, and blacks - Dr. Matthews interview with transcript - Jan 2019 15 May, 2019
Sleep, Vitamin D, B Vitamins, jaw, etc. Dr. Gominak transcript - 2016 31 Jan, 2019
History of Dr. Cannell and Vitamin D Council - Podcast with transcript - Dec 2014 05 Dec, 2014
Vitamin D and bone health - Univ of Maryland video and transcript May 2010 02 Jul, 2010

42 Virus meta-analyses on VitaminDWiki

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

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VitaminDWiki – Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023

November 2022 https://c19early.org/
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Comment by Chambers: all those under $165 are also anti-oxidants


Countries of recent Meta-analyses of Vitamin D and COVID

Italy Jan 2023
Eqypt Dec 2022
Iran Sept 2022
Italy July 2022
India Jan 2022
Italy Dec 2021
Sri Lanka Dec 2021
GreeceDec 2021
TurkeyOct 2021
Poland Oct 2021
ItalyOct 2021

Note: before vaccines there were many publications concerning Vitamin D and COVID


Vitamin D is very safe, rarely toxic and never deadly