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Sore mouth due to cancer therapy (oral mucositis) substantially reduced by daily 1,000 IU of vitamin D – June 2017

Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment

Contemp Oncol (Pozn). 2017; 21(2): 145–151, online 2017 Jun 30. doi: 10.5114/wo.2017.68623
PMCID: PMC5611504
Akshay Anand,1 Suyash Singh,1 Abhinav A. Sonkar,corresponding author1 Nuzhat Husain,2 Kul Ranjan Singh,1 Sudhir Singh,1 and Jitendra K. Kushwaha1

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See also web

  • Medscape
    “Oral mucositis is a common complication of cancer chemotherapy. It begins 5-10 days after the initiation of chemotherapy and lasts 7-14 days. Chemotherapy-induced oral mucositis causes the mucosal lining of the mouth to atrophy and break down, forming ulcers”
  • Mucositis Wikipedia
    “Oral and gastrointestinal (GI) mucositis affects almost all patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT), 80% of patients with malignancies of the head and neck receiving radiotherapy, and a wide range of patients receiving chemotherapy.”
    “For most cancer treatment, about 5–15% of patients get mucositis”
    “Seventy-five to eighty percent of bone marrow transplantation recipients experience mucositis,”
    “In grade 3 oral mucositis, the patient is unable to eat solid food, and in grade 4, the patient is unable to consume liquids as well”
    Radiotherapy to the head and neck Grade 3 oral mucositis - often exceeding 50% of patients


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Note SPSS = swallowing performance status scale
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Aim of the study
Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.

Material and methods
Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL.

Results
Vitamin D receptor expression was increased in oral neoplastic lesions. Vitamin D scores were significantly lower in cases compared to healthy controls (p = 0.002). Vitamin D supplementation significantly reduced the therapy-related toxicities in advanced cancer, thus reducing morbidity and improving QOL.

Conclusions
Vitamin D receptor expression is increased in premalignant lesions and oral cancer. Vitamin D insufficiency and deficiency are prevalent in patients with oral neoplastic lesions. Vitamin D supplementation has a role in reducing treatment-related toxicities, especially in advanced cancer.


Created by admin. Last Modification: Sunday April 29, 2018 17:48:59 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
8646 SPSS.jpg admin 06 Nov, 2017 71.88 Kb 891
8645 VDR Cancer.pdf admin 06 Nov, 2017 793.68 Kb 926
8644 Oral mucositis.jpg admin 06 Nov, 2017 112.34 Kb 943