Sleep duration as an independent factor associated with vitamin D levels in the EPISONO cohort
J Clin Sleep Med. 2021 Jun 21. doi: 10.5664/jcsm.9452 (no sci-hub as of Sept 2021)
Daniela Leite de Oliveira 1, Vinícius Dokkedal-Silva 1, Guilherme Luiz Fernandes 1, Lenise Jihe Kim 1, Sergio Tufik 1, Monica Levy Andersen 1
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Sleep, Dr. Gominak and Vitamin D - several studies
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
Note: That study did not appear to breakout the results for men vs women
Study objectives: Obstructive sleep apnea (OSA) and short sleep duration have been separately associated with inadequate serum 25-hydroxyvitamin D (25OHD) levels. However, whether these 2 factors may concurrently influence 25OHD in the general population is unknown. We hypothesized that both OSA and short sleep duration would be independently associated with lower concentrations of 25OHD in a gender-dependent manner.
Methods: In this cross-sectional study, 712 individuals, part of the prospective EPISONO cohort (Brazil), underwent polysomnography, answered sleep questionnaires, and had their blood collected for serum 25OHD quantification.
Results: Individuals with a sleep duration of <6 hours had 2-fold increased odds of 25OHD<20 ng/mL compared to those who reported 6 or more hours of sleep, even after adjusting for confounding factors.
Subset gender analysis revealed that men with a sleep duration of <6 hours had 4-fold increased odds of 25OHD<20 ng/mL. In women, short sleep duration was not associated with lower 25OHD levels. The presence of OSA (as classified according to the individual's Apnea-Hypopnea Index (AHI) was not independently related to 25OHD concentrations in men or women. Sleep parameters, including sleep latency and sleep efficiency, had no association with 25OHD<20 ng/mL.
Conclusions: Short sleep, but not AHI, was an independent factor associated with low 25OHD serum levels in men, but not in women. AHI scores were not associated with 25OHD levels in neither gender. These results raise the possibility of investigating gender-specific characteristics, such as gonadal hormone regulation, and re-evaluating obstructive events by classifying them in mild, moderate, and severe OSA.
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