Vitamin D and walking speed in older adults: Systematic review and meta-analysis.
Maturitas. 2017 Dec;106:8-25. doi: 10.1016/j.maturitas.2017.07.012. Epub 2017 Aug 8.
- Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016
- Slow gait is 3.5X more likely with low vitamin D and high C-Reactive Protein – Aug 2013
- Seniors with more than 30ng of vitamin D walked better – May 2011 coauthor: Annweiler
- Seniors having minimal Vitamin D and Vitamin K walked faster – Oct 2017
- More fast twitch muscles (IIA) are associated with higher levels of Vitamin D – Feb 2017
- Frailty can be avoided – vitamin D is one of the ways – July 2017
- Frailty 9X more likely if low vitamin D – Nov 2015
- Sarcopenia (muscle loss) fought by Vitamin D, exercise and protein - many studies
The Meta-analysis of Seniors and Vitamin D
- Overactive bladder 4.4 X more likely if low vitamin D – meta-analysis Feb 2024
- Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023
- Omega-3 improves elderly muscles – 2 meta-analyses
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Dementia is associated with low vitamin D - many studies
- Seniors 2.2 X more likely to walk slowly if very low vitamin D – meta-analysis Dec 2017
- Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017
- Resistance exercise combined with Vitamin D is great for seniors – meta-analysis July 2017
- Vitamin D supplementation help muscles of seniors who are vitamin D deficient – meta-analysis July 2014
- Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013
- Vitamin D improves muscle strength if deficient – meta-analysis - Oct 2010
- Meta-analysis of RCT – vitamin D might increase senior muscle function – Sept 2010
- 20 year review concludes that Vitamin D reduce ageing – July 2010
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following
- Senior skin produces 4X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptor genes as they age
Receptors are needed to get Vitamin D in blood actually into the cells - Many other Vitamin D genes decrease with age
- Since many gene activations are not detected by a blood test,
more Vitamin D is often needed, especially by seniors - Seniors are indoors more than when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures - Seniors wear more clothing outdoors than when younger
Seniors also are told to fear skin cancer & wrinkles - Seniors often take various drugs which end up reducing vitamin D
Some reductions are not detected by a vitamin D test of the blood
statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc - Seniors often have one or more diseases that consume vitamin D
osteoporosis, diabetes, Multiple Sclerosis, Cancer, ... - Seniors generally put on weight as they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
- Vitamin D is not as bioavailable in senior intestines
- Seniors with poorly functioning kidneys do not process vitamin D as well
- Glutathione (which increases Vitamin D getting to cells) decreases with age
Seniors category has430 items Download the PDF from sci-hub via VitaminDWiki Annweiler C1, Henni S2, Walrand S3, Montero-Odasso M4, Duque G5, Duval GT6.
- 1 Department of Neuroscience and Aging, Division of Geriatric Medicine and Memory Clinic, Research Centre on Autonomy and Longevity, Angers University Hospital, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address: CeAnnweiler at chu-angers.fr.
- 2 Department of Sports Medicine and Vascular Investigations, University Hospital, Angers, France.
- 3 Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000 Clermont-Ferrand, France.
- 4 Department of Medicine, Division of Geriatric Medicine, Parkwood Institute, Gait and Brain Lab, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada.
- 5 Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health,St. Albans, Victoria, Australia; Department of Medicine - Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, Victoria, Australia.
- 6 Department of Neuroscience and Aging, Division of Geriatric Medicine and Memory Clinic, Research Centre on Autonomy and Longevity, Angers University Hospital, UPRES EA 4638, University of Angers, UNAM, Angers, France.
Vitamin D is involved in musculoskeletal health. There is no consensus on a possible association between circulating 25-hydroxyvitamin D (25OHD) concentrations and walking speed, a 'vital sign' in older adults. Our objective was to systematically review and quantitatively assess the association of 25OHD concentration with walking speed. A Medline search was conducted on June 2017, with no limit of date, using the MeSH terms "Vitamin D" OR "Vitamin D Deficiency" combined with "Gait" OR "Gait disorders, Neurologic" OR "Walking speed" OR "Gait velocity". Fixed-effect meta-analyses were performed to compute: i) mean differences in usual and fast walking speeds and Timed Up and Go test (TUG) between participants with severe vitamin D deficiency (≤25nmol/L) (SVDD), vitamin D deficiency (≤50nmol/L) (VDD), vitamin D insufficiency (≤75nmol/L) (VDI) and normal vitamin D (>75nmol/L) (NVD); ii) risk of slow walking speed according to vitamin D status. Of the 243 retrieved studies, 22 observational studies (17 cross-sectional, 5 longitudinal) met the selection criteria. The number of participants ranged between 54 and 4100 (0-100% female). Usual walking speed was slower among participants with hypovitaminosis D, with a clinically relevant difference compared with NVD of -0.18m/s for SVDD, -0.08m/s for VDD and -0.12m/s for VDI. We found similar results regarding the fast walking speed (mean differences -0.04m/s for VDD and VDI compared with NVD) and TUG (mean difference 0.48s for SVDD compared with NVD). A slow usual walking speed was positively associated with SVDD (summary OR=2.17 [95%CI:1.52-3.10]), VDD (OR=1.38 [95%CI:1.01-1.89]) and VDI (OR=1.38 [95%CI:1.04-1.83]), using NVD as the reference. In conclusion, this meta-analysis provides robust evidence that 25OHD concentrations are positively associated with walking speed among adults.
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