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Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – meta-analysis Oct 2018

The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis

Nutrients 2018, 10(10), 1395; https://doi.org/10.3390/nu10101395 (registering DOI)
Qi Gao 1, Tingyan Kou 1, Bin Zhuang 2, Yangyang Ren 1, Xue Dong 1 and Qiuzhen Wang 1,*qdwangqiuzhen@126.com
1 Department of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
2 Department of the medical college of Qingdao University, Qingdao 266021, China


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Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included.
By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of s

  • sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72).

Subgroup analysis showed that VDD also was associated with

  • poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05),
  • short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and
  • sleepiness (OR: 1.36, 95% CI: 1.12, 1.65).

Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep.
This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

Created by admin. Last Modification: Saturday June 22, 2019 16:02:33 GMT-0000 by admin. (Version 8)

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10634 Sleep meta-min.pdf PDF 2018 admin 01 Oct, 2018 14:42 408.88 Kb 542