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Pneumonia 6X more likely if very low vitamin D – meta-analysis Sept 2019

The association between vitamin D deficiency and community-acquired pneumonia - A meta-analysis of observational studies

Medicine (Baltimore). 2019 Sep; 98(38): doi: 10.1097/MD.0000000000017252
Yun-Fang Zhou, MM,a Bang-An Luo, MM,b,∗ and Lu-Lu Qin, MD, PhDc,∗

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If Vitamin D <10ng

Image

Emerging evidence has shown that vitamin D deficiency may be related with community-acquired pneumonia (CAP), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the CAP.

We conducted this meta-analysis though a systematic literature search of PubMed, Medline, and EMBASE up to 31 September 2018 with the following keywords ‘vitamin D’ or ‘cholecalciferol’ or ‘25-hydroxyvitamin D’ or ‘25(OH)D’ in combination with ‘community-acquired pneumonia’ or ‘CAP’ or ‘pneumonia’ with no limitations. This meta-analysis was performed following the guidelines of Meta-analysis of Observational Studies in Epidemiology. The association between vitamin D levels and CAP were measured as odds ratio (OR) and weighted mean difference (WMD). Results were combined using a random-effect or a fix-effect meta-analysis, and sensitivity analyses were conducted to explore potential factors.

Eight observational studies involving 20,966 subjects were included. In this meta-analysis, CAP patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of CAP (odds ratio (OR) = 1.64, 95% confidence intervals (CI): 1.00, 2.67), and an obvious decrease of −5.63 ng/mL (95% CI: −9.11, −2.14) in serum vitamin D was demonstrated in CAP patients. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect.

The evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of CAP patients. However, well-designed trails are required to determine the explicit effect of vitamin D supplementation.


Clipped from PDF

  • "The patients of CAP in the US was estimated to be 5.6 million every year, among which about 1.1 million patients that needed hospitalization.1 The average in-hospital duration of CAP patients was 1 week in the US, the 30-day mortality rate was above 20%, and the mortality rate within 1 year of CAP patients after discharge was about 30%"
  • "A total of 20,966 participants were consisted of various ethnicities. Age ranged from 3 days to 94 years old, ..."
  • "...death rates of CAP patients during in-hospital treatment were far higher than other causes of death and ranked second among all in-hospital patients"
  • "...severe vitamin D deficiency (SVDD), with high heterogeneity (OR= 6.65, 95%CI: 2.58, 17.15, I2=90%)
    • Note: SVDD is < 10 ng

Created by admin. Last Modification: Friday October 18, 2019 14:28:59 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
12819 CAP 6X.jpg admin 18 Oct, 2019 65.96 Kb 754
12818 pneumonia meta.pdf admin 18 Oct, 2019 773.80 Kb 522