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Overview Alzheimer's-Cognition and Vitamin D

Table of contents

Cognitive category in VitaminDWiki starts with

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

338 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (6 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (48 studies), Intervention (18 studies), Meta-analyses (21 studies), Depression (21 studies), Parlinson's (18 studies),  Click here for details

Vitamin D pages containing "Dementia" in title (40 as of April 2022)
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392


Low Vitamin D getting to brain cells associated with various problems

Vitamin D and neurology Wikipedia]
Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
In some cases the low vitamin D in cells is due to poor Vitamin D Receptors
Items in both categories Cognitive and Vitamin D Receptor are listed here:


VitaminDWik Meta-analyses with ALZHEIMER in title (12 as of Sept 2022)

This list is automatically updated

Items found: 12

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VitaminDWiki pages with ALZHEIMER in title (81 as of Sept 2022)

This list is automatically updated

Items found: 81
Title Modified
COVID increased seniors risk of Alzheimer's by 1.7X in the next year- Sept 2022 16 Sep, 2022
Alzheimer's disease 9X more likely in females with a poor Vitamin D Receptor – Sept 2022 27 Aug, 2022
Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022 11 Aug, 2022
Alzheimer’s delayed 4.7 years by high Omega-3 index (7.6 years if also have APOE-4) June - 2022 17 Jun, 2022
Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022 11 Apr, 2022
Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022 08 Apr, 2022
Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018 14 Mar, 2022
Overview Alzheimer's-Cognition and Vitamin D 09 Feb, 2022
Alzheimer's 3X higher risk in countries with high meat consumption - 2016 01 Feb, 2022
End of Alzheimer's video and transcript - Oct 2021 09 Nov, 2021
Mutated gene, OAS1, which lowers vitamin D in brain, increases Alzheimers and severe COVID-19 – Oct 2021 15 Oct, 2021
Omega-3 paused Alzheimer's decline - RCT Sept 2021 11 Sep, 2021
2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021 25 Jun, 2021
The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc. 14 Jun, 2021
Medicare kicks-back 6 percent of price of an administered drug to physicians, perhaps 6 billion dollars annually for Aduhelm (Alzheimer’s) drugs 13 Jun, 2021
Vitamin D influences inflammation and Alzheimer’s genes (in mice) – March 2021 09 Apr, 2021
Alzheimer’s Disease risk is 1.9 X higher if Vitamin D deficient- meta-analysis Feb 2020 06 Feb, 2020
Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019 10 Dec, 2019
Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019 16 Nov, 2019
Alzheimer’s cognitive decline is 3X faster if low vitamin D – May 2017 12 Jun, 2019
Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018 01 May, 2019
Resveratrol for Alzheimer's disease – Sept 2017 27 Apr, 2019
Omega-3 helped Alzheimer’s only if good level of B vitamins – RCT April 2019 10 Apr, 2019
Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019 23 Mar, 2019
8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019 23 Mar, 2019
African Americans are more likely than whites to develop Alzheimer’s (Vitamin D) 29 Jan, 2019
Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018 12 Dec, 2018
Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018 27 Nov, 2018
Hypothesis: Low Vitamin D is a cause of Alzheimer’s Disease – 2014 23 Nov, 2018
Multiple Sclerosis, Alzheimer’s and Parkinson’s need more than 30 ng of Vitamin D – review Nov 2017 24 Sep, 2018
Alzheimer’s (apoE4) may require more than Omega-3 - May 2017 18 Sep, 2018
Alzheimer’s associated with low sun and low vitamin D – Sept 2018 18 Sep, 2018
Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015 18 Sep, 2018
Hypothesis: Omega-3 reduces Alzheimer’s directly and via the gut – Sept 2018 11 Sep, 2018
Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018 02 Sep, 2018
The Startling Link Between Sugar and Alzheimer's 02 Jun, 2018
Alzheimer’s increase due to less sun or more meat 22 Apr, 2018
Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Alzheimer's disease – less risk if smarter, higher vitamin D, better genes or less coffee – Dec 2017 08 Dec, 2017
Alzheimer’s, Parkenson’s, and Multiple Sclerosis – vitamin D may prevent and treat – Oct 2017 07 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017 07 Oct, 2017
Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017 02 Oct, 2017
Alzheimer plaque possibly cleared by Vitamin D – Nov 2017 02 Aug, 2017
Alzheimer's disease most likely will need more than monotherapy such as vitamin D – May 2013 27 Apr, 2017
Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014 05 Mar, 2017
Genes which reduce blood-level vitamin D increase the risk of Alzheimer’s disease – Dec 2016 18 Jan, 2017
Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013 13 Oct, 2016
DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014 13 Oct, 2016
Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 23 Sep, 2016
Decrease of Alzheimer’s biomarker halted by Resveratrol (perhaps due to vitamin D) – RCT Sept 2015 08 Aug, 2016
Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015 16 Apr, 2016
Poor Cognition and Alzheimer’s Disease both associated with low vitamin D – review May 2015 16 Apr, 2016
Alzheimer risk reduced by combination of memantine and vitamin D (patented) – Jan 2014 16 Apr, 2016
Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012 16 Apr, 2016
Alzheimer’s 4X less likely with high level of vitamin D – 2 studies April 2012 16 Apr, 2016
Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013 13 Dec, 2015
Alzheimer's Disease more likely with low vitamin D – meta-analysis Oct 2012 13 Dec, 2015
Off Topic: Heat Shock Proteins (sauna etc) prevent clumping in Alzheimer’s – Oct 2015 24 Oct, 2015
Alzheimer’s Disease is associated with vitamin D and genes – Aug 2015 10 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012 10 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D gene – 2012 10 Sep, 2015
Alzheimer’s may be treated by vitamin D3 and curcumin – March 2012 01 Sep, 2015
Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015 07 Aug, 2015
Alzheimer disease 5X less likely with nonmelanoma skin cancer (lots of vitamin D) – May 2013 01 Aug, 2015
5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 17 Jul, 2015
Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 18 May, 2015
Why vitamin D in Alzheimer's disease - a hypothesis – Jan 2014 16 Nov, 2014
Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 06 May, 2014
Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013 05 May, 2014
Hypothesis – Alzheimer’s Disease results of hormone imbalance (vitamin D etc.) – Jan 2014 15 Jan, 2014
Comparison of Alzheimer's Disease and Parkinson's Disease – Sept 2013 27 Dec, 2013
Vitamin D and MS, ALS, Autism, Alzheimer’s and other nervous system diseases – review Aug 2013 27 Dec, 2013
Alzheimer's disease 30 percent more likely in the 30 years after a low vitamin D test – July 2013 23 Jul, 2013
Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013 22 May, 2013
Alzheimer’s patients not on medication have very low levels of Vitamin D2 – Nov 2012 12 Nov, 2012
Alzheimer disease associated with 2.5 ng less vitamin D – meta-analysis Sept 2012 09 Oct, 2012
Link between diabetes and Alzheimers is probably low vitamin D 26 Sep, 2012
Alzheimer's probability decreased 77 percent with just 51 IU more vitamin D daily – April 2012 16 Sep, 2012

Cognition and Dementia in VitaminDWiki

18Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

update at The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc. including 3 books, latest Aug 2021

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s 3 times more likely if poor VDR

Vitamin D Receptor category has the following

464 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 44 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (17 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (22 studies), Cognition (16 studies), Diabetes (22 studies), Hypertension (6 studies), Infant (18 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (22 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (30 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 45 diseases at least double with poor VDR as of Nov 2022  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart


Alzheimer's patients had lower levels of viamin D in Cerebrospinal Fluid - Feb 2022

Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
J Alzheimers Dis. 2022 Feb 15. doi: 10.3233/JAD-215536
Jelena Zugic Soares 1 2 3, Jørgen Valeur 3, Jūratė Šaltytė Benth 4 5, Anne-Brita Knapskog 6, Geir Selbæk 2 6 7, Golchin Arefi 8, D Gregor Gilfillan 8, Anita Tollisen 3, Nenad Bogdanovic 6 9, Renate Pettersen 1

Background: Vitamin D insufficiency has been suggested as a dementia risk factor.

Objective: In this cross-sectional, explorative study we investigated whether levels of vitamin D in cerebrospinal fluid (CSF) are lower in patients with positive biomarkers of Alzheimer's disease (AD) compared to cognitively healthy controls and whether polymorphisms of the vitamin D receptor (VDR) gene, FokI, BsmI, ApaI, and TaqI, are associated with levels of vitamin D in CSF and cognition.

Methods: We included 100 patients≥65 years assessed for cognitive impairment and 76 cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D) in both serum and CSF, and VDR polymorphisms were analyzed.

Results: The mean level of 25(OH)D in serum was 78.6 (SD 28.9) nmol/l. While serum levels of 25(OH)D were not significantly different between the groups, CSF levels of 25(OH)D were significantly lower in patients with positive AD core biomarkers (p = 0.001) compared to patients without such biomarkers. Individuals with the BsmI major homozygote genotype had significantly lower results on a 10-word delayed recall test (p = 0.044) and verbal fluency test (p = 0.013), and individuals with the TaqI major homozygote genotype had significantly lower results on a verbal fluency test (p = 0.030) compared to individuals with the corresponding minor homozygote genotype.

Conclusion: Patients with positive AD core biomarkers have low CSF levels of 25(OH)D, despite sufficient serum levels. CSF levels of 25(OH)D do not seem to be affected by any of the four VDR gene polymorphisms. TaqI and BsmI major homozygote genotypes might be at increased risk for development of cognitive decline.


Playing music from a patient's youth helps with dementia, Alzheimer's, Parkinson's

On the WEB

  • Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease - Jan 2013, https://doi.org/10.1016/j.yfrne.2012.07.001
  • Vitamin D and the brain - Aug 2011 https://doi.org/10.1016/j.beem.2011.05.009
  • How Vitamin D Protects Brain Function Life Extension Magazine 2018?
  • Dementia is sometimes due to Vitamin B12 deficiency - May 2019 doi: 10.1136/bcr-2018-229044.
    • "Reversible dementia, psychotic symptoms and epilepsy in a patient with vitamin B12 deficiency"
  • Cognitive Imparement Vitamin D Council update Sept 2017
  • Is Alzheimer’s Type 3 Diabetes? New York Times Sept 2012
    • Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    • people with diabetes are at least twice as likely to get Alzheimer’s
  • PubMed Alzheimer's AND Insulin in title 299 items as of Dec 2017
    • "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
    • "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
    • "Insulin resistance in Alzheimer's disease." May 2017
  • Vitamin D and neurology WikiPedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 including vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes: should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you can be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copy of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
    • Supplementing vitamin D, etc virtually eliminates my increased risk
    • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • 7 Conditions Masquerading As Dementia GreenMed Info Aug 2018
    Does not mention which the 7 are, but does point to huge success at reversing dementia - using major changes - including supplementing with Vitamin B12, vitamin D, CoQ10 and Omega-3
  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: " Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:


Clinical Trials for Cognition and Vitamin D INTERVENTION


Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Image
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki


Age-adjusted Death rates: Alzheimer's has been increasing the fastest

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Big increase if both parents had Alzheimer's

Image

54% of ALL people, of all ages, are now "touched" by Alzheimer's

Image

Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimer's' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Health Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due to caregiving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013

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Alzheimer's in more than half of hospital patients over age 65

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Half of care-giving for 6+ years is due to Alzheimer's or other dementia

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Work changes due to Alzheimer's or Dimentia care-giving

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What if we could delay the onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
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Looks like about half of the people would not have Alzheimer's costs (die sooner?)


Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag


Items in BOTH Cognition and Omega-3 categories


APOE4 gene greatly increases the risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the childbearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki


Small amount of Lithium slowed dementia in Alzheimer's


Safron treats Alzheimer's as well as drugs, but without side affects - June 2021

__Saffron Put to the Test for Alzheimer’s Dr. Greger

  • Study was funded by BIG SAFRON = Iran (not BIG PHARMA)
  • Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types - June 2020 https://doi.org/10.1111/jfpp.14629 FREE PDF
  • Note: Various suppliers of Safron in combination with Vitamin D

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017


Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"
  • Why Bill Gates-backed a $30 million fight against Alzheimer’s July 2018
    give profit incentive to groups deploying early detection of Alzheimer's
    His family (father?) has Alzheimer's

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10-year experiment, full free text online
Speed of processing training results in lower risk of dementia


Types of Mental Disorders (no mention of low vitamin D) - 2017?

Image
Bipolar Bandit has detailed descriptions and references


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Alzheimer's risk reduced by Vit D, Vit C, Omega-3, Zinc, etc more than cancels the increased risk due to APOE-4 problems - July 2018

Why Is Modern Medicine Aiming To Reduce Risk For Alzheimer's Disease With Expensive Gene Editing Technology When Fish Oil, Antioxidants & Metal Chelation Are More Effective & Economical? Bill Sardi

  1. The alternative therapies cancel the increased risk of Alzheimer's due to gene problems
    Gene Therapy ignores the other causes of Alzheimer's and other forms of dementia
  2. The alternative therapies are far far less costly than gene therapy
    might cost $200 Billion to provide gene therapy to everyone with the APOE-4 gene problem

Copper + saturated fat (cholesterol) found to increase the rate of Cognitive Decline by 3X


Alzheimer's rate especially increasing in groups at high risk of Low Vitamin D (Dark Skin)

Image

 

 
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reference for both graphics


Hallmarks of Alzheimer's Are Stimulated by This Substance Mercola
Interview of Boyd Haley, Ph.D., Video and Transcript

  • {...enzyme creatine kinase, which is a fundamental enzyme, is 98 percent inhibited in Alzheimer's patients..."
  • "All Biochemical Abnormalities and Hallmarks of Alzheimer's Are Stimulated by Mercury"
  • In 2014 Haley wrote a paper "Evidence Supporting a Link Between Dental Amalgams and Chronic Illness, Fatigue, Depression, Anxiety and Suicide."
  • "The Relationship of Toxic Effects of Mercury to Exacerbation of the Medical Condition classified as Alzheimer’s Disease" byHaley

>12 million will have Alzheimer’s in the US in 2050

Image
web


Safron as good as Alzheimer's drug, but without the side effects - June 2021

  • Saffron Put to the Test for Alzheimer’s Dr Greger
    • Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial - 2014
    • Note: As of June 2021 various suppliers produce Safron in combination with Vitamin D
    • Also:"Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types" - June 2020 - https://doi.org/10.1111/jfpp.14629 PDF costs $14

Rates of Death due to Alz and Dementia vary a lot between countries

Image
World Heath Rangings July 2021
Example: US death rate is 6X of that of Japan (34.8 vs 5.2)


Daily multivitamin slowed cognitive decline by 60%: placebo-controlled trial - Nov 2021

Multivitamins, but not cocoa, tied to slowed brain aging MDEdge Nov 11, 2021
Better and better during the trial, but plateaued at 2 years
Presented at a conference. A comment was made that the benefit might form Vitamin B12 in the multivitamin


Title change made Nov 2021 caused the visitor count to reset.
There have actually been 151277 visitors to this page since it was originally made


short url = http://is.gd/dcognition


Created by admin. Last Modification: Wednesday September 21, 2022 17:32:01 GMT-0000 by admin. (Version 411)
Overview Alzheimer's-Cognition and Vitamin D        
9945 visitors, last modified 21 Sep, 2022,
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Attached files

ID Name Comment Uploaded Size Downloads
15976 Dimentia Death Ratee - female.jpg admin 27 Jul, 2021 17:45 62.26 Kb 1590
15742 Alz predicted prevalence.jpg admin 13 Jun, 2021 11:34 41.38 Kb 1704
13318 Boyd Haley Alz.pdf admin 12 Jan, 2020 12:19 2.50 Mb 852
10890 Alz 2030.jpg admin 23 Nov, 2018 18:07 53.79 Kb 5443
10889 Alz dark skin.jpg admin 23 Nov, 2018 17:57 38.32 Kb 5503
9924 Mental disorders.jpg admin 04 Jun, 2018 19:10 165.44 Kb 6527
9546 Dementia vs Alzheimer's.jpg admin 19 Mar, 2018 09:19 55.26 Kb 7970
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 22:00 21.45 Kb 11670
7795 Therapeutic Benefit is in the D-Tails.pdf PDF 2016 admin 05 Mar, 2017 21:59 523.25 Kb 863
7627 Survival Of The Sickest - 2008 book.pdf PDF admin 06 Jan, 2017 22:52 947.50 Kb 11432
7553 Lithium to the Rescue.pdf PDF 2016 admin 23 Dec, 2016 12:18 670.40 Kb 1536
7407 Lithium as Nutrient - 2015.pdf PDF 2015 admin 29 Nov, 2016 11:40 128.16 Kb 1680
7406 Lithium and Alz LEF Dec 2016.pdf PDF 2016 admin 28 Nov, 2016 23:56 3.40 Mb 2021
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 14:54 15.97 Kb 9624
7255 Delay Alz by 5 years - 2015.pdf PDF 2015 admin 29 Oct, 2016 14:50 1,015.63 Kb 2038
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 14:12 19.54 Kb 9861
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 14:06 38.45 Kb 9616
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 00:04 21.84 Kb 10022
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 23:46 37.59 Kb 10036
7250 Alzheimers Association facts and figures 2016.pdf PDF 2016 admin 28 Oct, 2016 23:45 2.07 Mb 3256
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 21:22 23.01 Kb 2751
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 21:21 23.94 Kb 9622
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 21:21 31.71 Kb 10749
4867 Dementia incidence.jpg admin 12 Jan, 2015 02:24 61.75 Kb 10789
4095 Alz nutrient status.pdf PDF 2014 admin 29 Jun, 2014 10:54 1.57 Mb 2101
3475 Death rates alzheimers.gif admin 02 Jan, 2014 17:37 38.58 Kb 24215
3469 Alzheimers percentage.png admin 29 Dec, 2013 11:57 49.40 Kb 32989
1131 Alzheimer\'s 2011.pdf PDF admin 04 Mar, 2012 15:28 1.09 Mb 7046
1130 Alz in hospital - 2011.jpg Go to hospital with Alz admin 04 Mar, 2012 15:24 34.72 Kb 9797
1129 Alz how long - 2011.jpg how long care needed admin 04 Mar, 2012 15:23 28.67 Kb 9403
1128 Alz F5 - 2011.jpg increases admin 04 Mar, 2012 15:23 20.73 Kb 9708
1120 Potential targets for Alz.jpg targets from D-Mentia admin 26 Feb, 2012 21:01 21.24 Kb 12072
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 21:00 292.71 Kb 3001
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