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Multiple Sclerosis 42X more likely if light brown skin and smoke (both associated with low vitamin D) – July 2020

Skin Phototype Could Be a Risk Factor for Multiple Sclerosis

J Clin Med. 2020 Jul 26;9(8):E2384. doi: 10.3390/jcm9082384.
Patricia Urbaneja 1 2 3, Isaac Hurtado-Guerrero 1 2 3, Miguel Ángel Hernández 3 4, Begoña Oliver-Martos 1 2 3, Celia Oreja-Guevara 3 5, Jesús Ortega-Pinazo 1 2, Ana Alonso 1 2 3, Francisco J Barón-López 1 6 7, Laura Leyva 1 2 3, Óscar Fernández 1 8, María Jesús Pinto-Medel 1 2 3


Items in both categories MS and Dark Skin are listed here:

Overview Dark Skin and Vitamin D contains the following summary
FACT - - People with dark skins have more health problems and higher mortality rate than those with light skins
FACT - - People with dark skins have low levels of vitamin D
FACT - - People with light skins who have low vitamin D have health problems
OBSERVATION - - The health problems of whites with low level of vitamin D are similar to those with dark skins
CONCLUSION - - People with dark skins have more health problems due to low levels of vitamin D
African American Health Disparities are associated with low Vitamin D - Grant Feb 2021
Low Vitamin D increases health problems - independent of skin color

Dark Skin studies: Pregnancy (28 studies),  Genetics (13 studies),  Vitamin D Binding Protein (8 studies),  Vitamin D Receptor (7 studies),  Diabetes (24 studies),   Cardiovascular (18 studies),  Mortality (12 studies), Intervention (16 studies) Click here to see the studies

 Download the PDF from VitaminDWiki

Environmental and genetic factors are assumed to be necessary for the development of multiple sclerosis (MS), however its interactions are still unclear. For this reason here, we have not only analyzed the impact on increased risk of MS of the best known factors (HLA-DRB1*15:01 allele, sun exposure, vitamin D levels, smoking habit), but we have included another factor (skin phototype) that has not been analyzed in depth until now. This study included 149 MS patients and 147 controls. A multivariate logistic regression (LR) model was carried out to determine the impact of each of the factors on the increased risk of MS. Receiver Operating Characteristics (ROC) analysis was performed to evaluate predictive value of the models. Our multifactorial LR model of susceptibility showed that females with light brown skin (LBS), smokers and who had HLA-DRB1*15:01 allele had a higher MS risk (LBS: OR = 5.90, IC95% = 2.39-15.45; smoker: OR = 4.52, IC95% = 2.69-7.72; presence of HLA-DRB1*15:01: OR = 2.39, IC95% = 1.30-4.50; female: OR = 1.88, IC95% = 1.08-3.30). This model had an acceptable discriminant value with an Area Under a Curve AUC of 0.76 (0.69-0.82). Our study indicates that MS risk is determined by complex interactions between sex, environmental factors, and genotype where the milieu could provide the enabling proinflammatory environment that drives an autoimmune attack against myelin by self-reactive lymphocytes.

Created by admin. Last Modification: Thursday July 30, 2020 13:48:09 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
14101 MS 42X more likely if LBS and Smoke.jpg admin 30 Jul, 2020 88.85 Kb 431
14100 MS risk factor percentages.jpg admin 30 Jul, 2020 52.88 Kb 393
14099 MS Risk factors brown skin, smoking, etc.jpg admin 30 Jul, 2020 60.31 Kb 477
14098 Dark Skin MS.pdf admin 30 Jul, 2020 1.25 Mb 503